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Abstract
Purpose: To determine the reproducibility of 3D proton magnetic resonance spectroscopic imaging (1H-MRSI) of the human prostate in a multicenter setting at 1.5T. Materials and Methods: Fourteen subjects were measured twice with 3D point-resolved spectroscopy (PRESS) (1)H-MRSI using an endorectal coil. MRSI voxels were selected in the peripheral zone and combined central gland at the same location in the prostate in both measurements. Voxels with approved spectral quality were included to calculate Bland-Altman parameters for reproducibility from the choline plus creatine to citrate ratio (CC/C). The repeated spectroscopic data were also evaluated with a standardized clinical scoring system. Results: A total of 74 voxels were included for reproducibility analysis. The complete range of biologically interesting CC/C ratios was covered. The overall within-voxel standard deviation (SD) of the CC/C ratio of the repeated measurements was 0.13. This value is equal to the between-subject SD of noncancer prostate tissue. In >90% of the voxels the standardized clinical score did not differ relevantly between the measurements. Conclusion: Repeated measurements of in vivo 3D (1)H-MRSI of the complete prostate at 1.5T produce equal and quantitative results. The reproducibility of the technique is high enough to provide it as a reliable tool in assessing tumor presence in the prostate.
Keywords
3T, TISSUE, SEXTANT LOCALIZATION, CANCER LOCALIZATION, reproducibility, MAGNETIC-RESONANCE-SPECTROSCOPY, HUMAN BRAIN, prostate cancer, magnetic resonance spectroscopic imaging

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Citation

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Chicago
Lagemaat, Miriam W, Christian M Zechmann, Jurgen J Futterer, Elisabeth Weiland, Jianping Lu, Geert Villeirs, Barbara A Holshouser, et al. 2012. “Reproducibility of 3D 1H MR Spectroscopic Imaging of the Prostate at 1.5T.” Journal of Magnetic Resonance Imaging 35 (1): 166–173.
APA
Lagemaat, M. W., Zechmann, C. M., Futterer, J. J., Weiland, E., Lu, J., Villeirs, G., Holshouser, B. A., et al. (2012). Reproducibility of 3D 1H MR spectroscopic imaging of the prostate at 1.5T. JOURNAL OF MAGNETIC RESONANCE IMAGING, 35(1), 166–173.
Vancouver
1.
Lagemaat MW, Zechmann CM, Futterer JJ, Weiland E, Lu J, Villeirs G, et al. Reproducibility of 3D 1H MR spectroscopic imaging of the prostate at 1.5T. JOURNAL OF MAGNETIC RESONANCE IMAGING. 2012;35(1):166–73.
MLA
Lagemaat, Miriam W, Christian M Zechmann, Jurgen J Futterer, et al. “Reproducibility of 3D 1H MR Spectroscopic Imaging of the Prostate at 1.5T.” JOURNAL OF MAGNETIC RESONANCE IMAGING 35.1 (2012): 166–173. Print.
@article{2018524,
  abstract     = {Purpose: To determine the reproducibility of 3D proton magnetic resonance spectroscopic imaging (1H-MRSI) of the human prostate in a multicenter setting at 1.5T. 
Materials and Methods: Fourteen subjects were measured twice with 3D point-resolved spectroscopy (PRESS) (1)H-MRSI using an endorectal coil. MRSI voxels were selected in the peripheral zone and combined central gland at the same location in the prostate in both measurements. Voxels with approved spectral quality were included to calculate Bland-Altman parameters for reproducibility from the choline plus creatine to citrate ratio (CC/C). The repeated spectroscopic data were also evaluated with a standardized clinical scoring system. 
Results: A total of 74 voxels were included for reproducibility analysis. The complete range of biologically interesting CC/C ratios was covered. The overall within-voxel standard deviation (SD) of the CC/C ratio of the repeated measurements was 0.13. This value is equal to the between-subject SD of noncancer prostate tissue. In {\textrangle}90\% of the voxels the standardized clinical score did not differ relevantly between the measurements. 
Conclusion: Repeated measurements of in vivo 3D (1)H-MRSI of the complete prostate at 1.5T produce equal and quantitative results. The reproducibility of the technique is high enough to provide it as a reliable tool in assessing tumor presence in the prostate.},
  author       = {Lagemaat, Miriam W and Zechmann, Christian M and Futterer, Jurgen J and Weiland, Elisabeth and Lu, Jianping and Villeirs, Geert and Holshouser, Barbara A and van Hecke, Paul and Lemort, Marc and Schlemmer, Heinz-Peter and Barentsz, Jelle O and Roell, Stefan O and Heerschap, Arend and Scheenen, Tom WJ},
  issn         = {1053-1807},
  journal      = {JOURNAL OF MAGNETIC RESONANCE IMAGING},
  keyword      = {3T,TISSUE,SEXTANT LOCALIZATION,CANCER LOCALIZATION,reproducibility,MAGNETIC-RESONANCE-SPECTROSCOPY,HUMAN BRAIN,prostate cancer,magnetic resonance spectroscopic imaging},
  language     = {eng},
  number       = {1},
  pages        = {166--173},
  title        = {Reproducibility of 3D 1H MR spectroscopic imaging of the prostate at 1.5T},
  url          = {http://dx.doi.org/10.1002/jmri.22827},
  volume       = {35},
  year         = {2012},
}

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