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Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships

Charlotte Grootaert UGent, Tom Van de Wiele UGent, Willy Verstraete UGent, Marc Bracke UGent and Barbara Vanhoecke UGent (2012) EXPERT REVIEW OF PROTEOMICS. 9(2). p.181-199
abstract
The angiopoietin-like protein 4 (ANGPTL4/FIAF) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and secreted into the blood stream in glycosylated, oligomerized, native and cleaved isoforms, to modulate physiological events such as angiogenesis, cell differentiation and the crosstalk between liver, brain, adipose and muscle tissue in lipid and glucose metabolism. In addition, the expression and isoform appearance of ANGPTL4 are modified by the intestinal microbiota. With eye on an effective strategy to improve health by ANGPTL4, we focus in this review on (i) health issues associated with ANGPTL4 expression, including obesity, type II diabetes, cardiovascular diseases and cancer, (ii) several modulators of FIAF of chemical, microbiological, food and host origin, and (iii) the correlation of the specific ANGPTL4 isoforms with these modulators and health effects.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
cancer, INDUCED ADIPOSE FACTOR, angiopoietin-like protein 4, bacteria, lipid metabolism, hypoxia, cleavage, TISSUE DISTRIBUTION, FATTY-ACIDS, TARGET GENE, LIPOPROTEIN-LIPASE, GENE-EXPRESSION, COILED-COIL DOMAIN, DIET-INDUCED OBESITY, ENDOTHELIAL GROWTH-FACTOR, ACTIVATED RECEPTOR-BETA/DELTA
journal title
EXPERT REVIEW OF PROTEOMICS
Expert Rev. Proteomics
volume
9
issue
2
pages
181 - 199
Web of Science type
Review
Web of Science id
000303033400013
JCR category
BIOCHEMICAL RESEARCH METHODS
JCR impact factor
3.896 (2012)
JCR rank
16/74 (2012)
JCR quartile
1 (2012)
ISSN
1478-9450
DOI
10.1586/EPR.12.12
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2018184
handle
http://hdl.handle.net/1854/LU-2018184
date created
2012-02-03 11:38:14
date last changed
2015-06-17 09:56:19
@article{2018184,
  abstract     = {The angiopoietin-like protein 4 (ANGPTL4/FIAF) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and secreted into the blood stream in glycosylated, oligomerized, native and cleaved isoforms, to modulate physiological events such as angiogenesis, cell differentiation and the crosstalk between liver, brain, adipose and muscle tissue in lipid and glucose metabolism. In addition, the expression and isoform appearance of ANGPTL4 are modified by the intestinal microbiota. With eye on an effective strategy to improve health by ANGPTL4, we focus in this review on (i) health issues associated with ANGPTL4 expression, including obesity, type II diabetes, cardiovascular diseases and cancer, (ii) several modulators of FIAF of chemical, microbiological, food and host origin, and (iii) the correlation of the specific ANGPTL4 isoforms with these modulators and health effects.},
  author       = {Grootaert, Charlotte and Van de Wiele, Tom and Verstraete, Willy and Bracke, Marc and Vanhoecke, Barbara},
  issn         = {1478-9450},
  journal      = {EXPERT REVIEW OF PROTEOMICS},
  keyword      = {cancer,INDUCED ADIPOSE FACTOR,angiopoietin-like protein 4,bacteria,lipid metabolism,hypoxia,cleavage,TISSUE DISTRIBUTION,FATTY-ACIDS,TARGET GENE,LIPOPROTEIN-LIPASE,GENE-EXPRESSION,COILED-COIL DOMAIN,DIET-INDUCED OBESITY,ENDOTHELIAL GROWTH-FACTOR,ACTIVATED RECEPTOR-BETA/DELTA},
  language     = {eng},
  number       = {2},
  pages        = {181--199},
  title        = {Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships},
  url          = {http://dx.doi.org/10.1586/EPR.12.12},
  volume       = {9},
  year         = {2012},
}

Chicago
Grootaert, Charlotte, Tom Van de Wiele, Willy Verstraete, Marc Bracke, and Barbara Vanhoecke. 2012. “Angiopoietin-like Protein 4: Health Effects, Modulating Agents and Structure-function Relationships.” Expert Review of Proteomics 9 (2): 181–199.
APA
Grootaert, C., Van de Wiele, T., Verstraete, W., Bracke, M., & Vanhoecke, B. (2012). Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships. EXPERT REVIEW OF PROTEOMICS, 9(2), 181–199.
Vancouver
1.
Grootaert C, Van de Wiele T, Verstraete W, Bracke M, Vanhoecke B. Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships. EXPERT REVIEW OF PROTEOMICS. 2012;9(2):181–99.
MLA
Grootaert, Charlotte, Tom Van de Wiele, Willy Verstraete, et al. “Angiopoietin-like Protein 4: Health Effects, Modulating Agents and Structure-function Relationships.” EXPERT REVIEW OF PROTEOMICS 9.2 (2012): 181–199. Print.