Advanced search
1 file | 2.08 MB

Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships

Charlotte Grootaert (UGent) , Tom Van de Wiele (UGent) , Willy Verstraete (UGent) , Marc Bracke (UGent) and Barbara Vanhoecke (UGent)
(2012) EXPERT REVIEW OF PROTEOMICS. 9(2). p.181-199
Author
Organization
Project
Biotechnology for a sustainable economy (Bio-Economy)
Abstract
The angiopoietin-like protein 4 (ANGPTL4/FIAF) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and secreted into the blood stream in glycosylated, oligomerized, native and cleaved isoforms, to modulate physiological events such as angiogenesis, cell differentiation and the crosstalk between liver, brain, adipose and muscle tissue in lipid and glucose metabolism. In addition, the expression and isoform appearance of ANGPTL4 are modified by the intestinal microbiota. With eye on an effective strategy to improve health by ANGPTL4, we focus in this review on (i) health issues associated with ANGPTL4 expression, including obesity, type II diabetes, cardiovascular diseases and cancer, (ii) several modulators of FIAF of chemical, microbiological, food and host origin, and (iii) the correlation of the specific ANGPTL4 isoforms with these modulators and health effects.
Keywords
cancer, INDUCED ADIPOSE FACTOR, angiopoietin-like protein 4, bacteria, lipid metabolism, hypoxia, cleavage, TISSUE DISTRIBUTION, FATTY-ACIDS, TARGET GENE, LIPOPROTEIN-LIPASE, GENE-EXPRESSION, COILED-COIL DOMAIN, DIET-INDUCED OBESITY, ENDOTHELIAL GROWTH-FACTOR, ACTIVATED RECEPTOR-BETA/DELTA

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 2.08 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Grootaert, Charlotte, Tom Van de Wiele, Willy Verstraete, Marc Bracke, and Barbara Vanhoecke. 2012. “Angiopoietin-like Protein 4 : Health Effects, Modulating Agents and Structure-function Relationships.” Expert Review of Proteomics 9 (2): 181–199.
APA
Grootaert, C., Van de Wiele, T., Verstraete, W., Bracke, M., & Vanhoecke, B. (2012). Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships. EXPERT REVIEW OF PROTEOMICS, 9(2), 181–199.
Vancouver
1.
Grootaert C, Van de Wiele T, Verstraete W, Bracke M, Vanhoecke B. Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships. EXPERT REVIEW OF PROTEOMICS. 2012;9(2):181–99.
MLA
Grootaert, Charlotte, Tom Van de Wiele, Willy Verstraete, et al. “Angiopoietin-like Protein 4 : Health Effects, Modulating Agents and Structure-function Relationships.” EXPERT REVIEW OF PROTEOMICS 9.2 (2012): 181–199. Print.
@article{2018184,
  abstract     = {The angiopoietin-like protein 4 (ANGPTL4/FIAF) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and secreted into the blood stream in glycosylated, oligomerized, native and cleaved isoforms, to modulate physiological events such as angiogenesis, cell differentiation and the crosstalk between liver, brain, adipose and muscle tissue in lipid and glucose metabolism. In addition, the expression and isoform appearance of ANGPTL4 are modified by the intestinal microbiota. With eye on an effective strategy to improve health by ANGPTL4, we focus in this review on (i) health issues associated with ANGPTL4 expression, including obesity, type II diabetes, cardiovascular diseases and cancer, (ii) several modulators of FIAF of chemical, microbiological, food and host origin, and (iii) the correlation of the specific ANGPTL4 isoforms with these modulators and health effects.},
  author       = {Grootaert, Charlotte and Van de Wiele, Tom and Verstraete, Willy and Bracke, Marc and Vanhoecke, Barbara},
  issn         = {1478-9450},
  journal      = {EXPERT REVIEW OF PROTEOMICS},
  keyword      = {cancer,INDUCED ADIPOSE FACTOR,angiopoietin-like protein 4,bacteria,lipid metabolism,hypoxia,cleavage,TISSUE DISTRIBUTION,FATTY-ACIDS,TARGET GENE,LIPOPROTEIN-LIPASE,GENE-EXPRESSION,COILED-COIL DOMAIN,DIET-INDUCED OBESITY,ENDOTHELIAL GROWTH-FACTOR,ACTIVATED RECEPTOR-BETA/DELTA},
  language     = {eng},
  number       = {2},
  pages        = {181--199},
  title        = {Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships},
  url          = {http://dx.doi.org/10.1586/EPR.12.12},
  volume       = {9},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: