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Outcome in critically ill patients with allogeneic BM or peripheral haematopoietic SCT: a single-centre experience

Pieter Depuydt UGent, Tessa Kerre UGent, Lucien Noens UGent, JOKE NOLLET UGent, Fritz Offner UGent, Johan Decruyenaere UGent and DOMINIQUE BENOIT UGent (2011) BONE MARROW TRANSPLANTATION. 46(9). p.1186-1191
abstract
Outcome in haematological patients who develop critical illness has significantly improved over the last two decades, but less so in allogeneic BMT recipients. We prospectively investigated the outcome of 44 haematological patients with allogeneic BM or haematopoietic SCT (ABMT/AHSCT) requiring admission to the intensive care unit (ICU) of Ghent University Hospital between January 2000 and December 2007. We related outcome to the cause of critical illness, which was categorized as documented or clinically suspected bacterial infection, non-bacterial infection and non-infectious disease. Mechanical ventilation was required in 32 patients, and 12 patients received renal replacement therapy. Overall ICU-mortality, in-hospital mortality and 6-month mortality rates were 61, 75 and 80%, respectively. Hospital mortality rates in patients with bacterial infection (n = 14), non-bacterial infection (n = 13) and non-infectious disease (n = 17) were 43, 85 and 94% (P = 0.003). After adjustment for severity of illness sequential organ failure assessment (SOFA) score, bacterial infection (odds ratio 0.06, 0.01-0.36, P = 0.002) was associated with significantly lower odds for hospital mortality. On the basis of our experience, ICU referral of ABMT/AHSCT patients is justifiable, as an acceptable fraction of these patients have longer-term survival. Documented or clinically suspected bacterial infection as the cause of critical illness is associated with better prognosis in comparison with other causes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MULTICENTER, MARROW TRANSPLANT PATIENTS, allogeneic BMT, intensive care unit, INTENSIVE-CARE-UNIT, RECIPIENTS, allogeneic haematopoietic SCT, CANCER-PATIENTS, HEMATOLOGICAL MALIGNANCIES, MECHANICAL VENTILATION, MORTALITY, ACUTE RESPIRATORY-FAILURE, STEM-CELL TRANSPLANTATION
journal title
BONE MARROW TRANSPLANTATION
Bone Marrow Transplant.
volume
46
issue
9
pages
1186 - 1191
Web of Science type
Article
Web of Science id
000294662700002
JCR category
TRANSPLANTATION
JCR impact factor
3.746 (2011)
JCR rank
6/24 (2011)
JCR quartile
2 (2011)
ISSN
0268-3369
DOI
10.1038/bmt.2010.255
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2016373
handle
http://hdl.handle.net/1854/LU-2016373
date created
2012-02-02 15:14:29
date last changed
2012-04-05 17:14:29
@article{2016373,
  abstract     = {Outcome in haematological patients who develop critical illness has significantly improved over the last two decades, but less so in allogeneic BMT recipients. We prospectively investigated the outcome of 44 haematological patients with allogeneic BM or haematopoietic SCT (ABMT/AHSCT) requiring admission to the intensive care unit (ICU) of Ghent University Hospital between January 2000 and December 2007. We related outcome to the cause of critical illness, which was categorized as documented or clinically suspected bacterial infection, non-bacterial infection and non-infectious disease. Mechanical ventilation was required in 32 patients, and 12 patients received renal replacement therapy. Overall ICU-mortality, in-hospital mortality and 6-month mortality rates were 61, 75 and 80\%, respectively. Hospital mortality rates in patients with bacterial infection (n = 14), non-bacterial infection (n = 13) and non-infectious disease (n = 17) were 43, 85 and 94\% (P = 0.003). After adjustment for severity of illness sequential organ failure assessment (SOFA) score, bacterial infection (odds ratio 0.06, 0.01-0.36, P = 0.002) was associated with significantly lower odds for hospital mortality. On the basis of our experience, ICU referral of ABMT/AHSCT patients is justifiable, as an acceptable fraction of these patients have longer-term survival. Documented or clinically suspected bacterial infection as the cause of critical illness is associated with better prognosis in comparison with other causes.},
  author       = {Depuydt, Pieter and Kerre, Tessa and Noens, Lucien and NOLLET, JOKE and Offner, Fritz and Decruyenaere, Johan and BENOIT, DOMINIQUE},
  issn         = {0268-3369},
  journal      = {BONE MARROW TRANSPLANTATION},
  keyword      = {MULTICENTER,MARROW TRANSPLANT PATIENTS,allogeneic BMT,intensive care unit,INTENSIVE-CARE-UNIT,RECIPIENTS,allogeneic haematopoietic SCT,CANCER-PATIENTS,HEMATOLOGICAL MALIGNANCIES,MECHANICAL VENTILATION,MORTALITY,ACUTE RESPIRATORY-FAILURE,STEM-CELL TRANSPLANTATION},
  language     = {eng},
  number       = {9},
  pages        = {1186--1191},
  title        = {Outcome in critically ill patients with allogeneic BM or peripheral haematopoietic SCT: a single-centre experience},
  url          = {http://dx.doi.org/10.1038/bmt.2010.255},
  volume       = {46},
  year         = {2011},
}

Chicago
Depuydt, Pieter, Tessa Kerre, Lucien Noens, JOKE NOLLET, Fritz Offner, Johan Decruyenaere, and Dominique Benoit. 2011. “Outcome in Critically Ill Patients with Allogeneic BM or Peripheral Haematopoietic SCT: a Single-centre Experience.” Bone Marrow Transplantation 46 (9): 1186–1191.
APA
Depuydt, P., Kerre, T., Noens, L., NOLLET, J., Offner, F., Decruyenaere, J., & Benoit, D. (2011). Outcome in critically ill patients with allogeneic BM or peripheral haematopoietic SCT: a single-centre experience. BONE MARROW TRANSPLANTATION, 46(9), 1186–1191.
Vancouver
1.
Depuydt P, Kerre T, Noens L, NOLLET J, Offner F, Decruyenaere J, et al. Outcome in critically ill patients with allogeneic BM or peripheral haematopoietic SCT: a single-centre experience. BONE MARROW TRANSPLANTATION. 2011;46(9):1186–91.
MLA
Depuydt, Pieter, Tessa Kerre, Lucien Noens, et al. “Outcome in Critically Ill Patients with Allogeneic BM or Peripheral Haematopoietic SCT: a Single-centre Experience.” BONE MARROW TRANSPLANTATION 46.9 (2011): 1186–1191. Print.