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Oral bioavailability of ATP after prolonged administration

(2011) BRITISH JOURNAL OF NUTRITION. 105(3). p.357-366
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Abstract
Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily intake of oral ATP is indeed bioavailable. Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets. In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels increased significantly after the administration of 5000 mg of ATP. Prolonged administration of ATP was safe as evidenced from liver and kidney parameters. We conclude that oral administration of ATP only resulted in increased uric acid concentrations. On the basis of these findings, we seriously question the claimed efficacy of oral ATP at dosages even lower than that used in the present study.
Keywords
Oral ATP administration, Human studies, SERUM URIC-ACID, CELL LUNG-CANCER, RANDOMIZED CLINICAL-TRIAL, LOW-BACK-PAIN, ADENOSINE 5'-TRIPHOSPHATE, CARDIOVASCULAR-DISEASE, NUTRITIONAL-STATUS, PATHOGENETIC ROLE, RISK-FACTOR, TRIPHOSPHATE

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Chicago
Coolen, Erik JCM, Ilja CW Arts, Otto Bekers, Chris Vervaet, Aalt Bast, and Pieter C Dagnelie. 2011. “Oral Bioavailability of ATP After Prolonged Administration.” British Journal of Nutrition 105 (3): 357–366.
APA
Coolen, E. J., Arts, I. C., Bekers, O., Vervaet, C., Bast, A., & Dagnelie, P. C. (2011). Oral bioavailability of ATP after prolonged administration. BRITISH JOURNAL OF NUTRITION, 105(3), 357–366.
Vancouver
1.
Coolen EJ, Arts IC, Bekers O, Vervaet C, Bast A, Dagnelie PC. Oral bioavailability of ATP after prolonged administration. BRITISH JOURNAL OF NUTRITION. 2011;105(3):357–66.
MLA
Coolen, Erik JCM, Ilja CW Arts, Otto Bekers, et al. “Oral Bioavailability of ATP After Prolonged Administration.” BRITISH JOURNAL OF NUTRITION 105.3 (2011): 357–366. Print.
@article{2016326,
  abstract     = {Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily intake of oral ATP is indeed bioavailable. Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets. In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels increased significantly after the administration of 5000 mg of ATP. Prolonged administration of ATP was safe as evidenced from liver and kidney parameters. We conclude that oral administration of ATP only resulted in increased uric acid concentrations. On the basis of these findings, we seriously question the claimed efficacy of oral ATP at dosages even lower than that used in the present study.},
  author       = {Coolen, Erik JCM and Arts, Ilja CW and Bekers, Otto and Vervaet, Chris and Bast, Aalt and Dagnelie, Pieter C},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keyword      = {Oral ATP administration,Human studies,SERUM URIC-ACID,CELL LUNG-CANCER,RANDOMIZED CLINICAL-TRIAL,LOW-BACK-PAIN,ADENOSINE 5'-TRIPHOSPHATE,CARDIOVASCULAR-DISEASE,NUTRITIONAL-STATUS,PATHOGENETIC ROLE,RISK-FACTOR,TRIPHOSPHATE},
  language     = {eng},
  number       = {3},
  pages        = {357--366},
  title        = {Oral bioavailability of ATP after prolonged administration},
  url          = {http://dx.doi.org/10.1017/S0007114510003570},
  volume       = {105},
  year         = {2011},
}

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