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Oral bioavailability of ATP after prolonged administration

Erik JCM Coolen, Ilja CW Arts, Otto Bekers, Chris Vervaet UGent, Aalt Bast and Pieter C Dagnelie (2011) BRITISH JOURNAL OF NUTRITION. 105(3). p.357-366
abstract
Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily intake of oral ATP is indeed bioavailable. Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets. In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels increased significantly after the administration of 5000 mg of ATP. Prolonged administration of ATP was safe as evidenced from liver and kidney parameters. We conclude that oral administration of ATP only resulted in increased uric acid concentrations. On the basis of these findings, we seriously question the claimed efficacy of oral ATP at dosages even lower than that used in the present study.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Oral ATP administration, Human studies, SERUM URIC-ACID, CELL LUNG-CANCER, RANDOMIZED CLINICAL-TRIAL, LOW-BACK-PAIN, ADENOSINE 5'-TRIPHOSPHATE, CARDIOVASCULAR-DISEASE, NUTRITIONAL-STATUS, PATHOGENETIC ROLE, RISK-FACTOR, TRIPHOSPHATE
journal title
BRITISH JOURNAL OF NUTRITION
Br. J. Nutr.
volume
105
issue
3
pages
357 - 366
Web of Science type
Article
Web of Science id
000287605400004
JCR category
NUTRITION & DIETETICS
JCR impact factor
3.013 (2011)
JCR rank
19/71 (2011)
JCR quartile
2 (2011)
ISSN
0007-1145
DOI
10.1017/S0007114510003570
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2016326
handle
http://hdl.handle.net/1854/LU-2016326
date created
2012-02-02 15:08:37
date last changed
2012-02-27 16:18:04
@article{2016326,
  abstract     = {Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily intake of oral ATP is indeed bioavailable. Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets. In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels increased significantly after the administration of 5000 mg of ATP. Prolonged administration of ATP was safe as evidenced from liver and kidney parameters. We conclude that oral administration of ATP only resulted in increased uric acid concentrations. On the basis of these findings, we seriously question the claimed efficacy of oral ATP at dosages even lower than that used in the present study.},
  author       = {Coolen, Erik JCM and Arts, Ilja CW and Bekers, Otto and Vervaet, Chris and Bast, Aalt and Dagnelie, Pieter C},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keyword      = {Oral ATP administration,Human studies,SERUM URIC-ACID,CELL LUNG-CANCER,RANDOMIZED CLINICAL-TRIAL,LOW-BACK-PAIN,ADENOSINE 5'-TRIPHOSPHATE,CARDIOVASCULAR-DISEASE,NUTRITIONAL-STATUS,PATHOGENETIC ROLE,RISK-FACTOR,TRIPHOSPHATE},
  language     = {eng},
  number       = {3},
  pages        = {357--366},
  title        = {Oral bioavailability of ATP after prolonged administration},
  url          = {http://dx.doi.org/10.1017/S0007114510003570},
  volume       = {105},
  year         = {2011},
}

Chicago
Coolen, Erik JCM, Ilja CW Arts, Otto Bekers, Chris Vervaet, Aalt Bast, and Pieter C Dagnelie. 2011. “Oral Bioavailability of ATP After Prolonged Administration.” British Journal of Nutrition 105 (3): 357–366.
APA
Coolen, E. J., Arts, I. C., Bekers, O., Vervaet, C., Bast, A., & Dagnelie, P. C. (2011). Oral bioavailability of ATP after prolonged administration. BRITISH JOURNAL OF NUTRITION, 105(3), 357–366.
Vancouver
1.
Coolen EJ, Arts IC, Bekers O, Vervaet C, Bast A, Dagnelie PC. Oral bioavailability of ATP after prolonged administration. BRITISH JOURNAL OF NUTRITION. 2011;105(3):357–66.
MLA
Coolen, Erik JCM, Ilja CW Arts, Otto Bekers, et al. “Oral Bioavailability of ATP After Prolonged Administration.” BRITISH JOURNAL OF NUTRITION 105.3 (2011): 357–366. Print.