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Phytochemicals and cancer chemoprevention: epigenetic friends or foe?

Katarzina Szarc vel Szic, Ajay Palagani UGent, Behrouz Hassannia UGent, Linde Sabbe UGent, Karen Heyninck UGent, Guy Haegeman UGent and Wim Vanden Berghe UGent (2011) Phytochemicals : bioactivities and impact on health. p.159-198
abstract
Cancer, as one of the non-communicable diseases, remains one of the leading causes of death around the world. Since immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and therapy sensitivity. Recent successes of therapeutic interventions in cancer and inflammatory diseases using epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA methylation suggest that epigenetic reprogramming plays an important role in the aetiology of these diseases. Epigenetic changes in DNA methylation patterns at CpG sites (epimutations) or corrupt chromatin states of tumor promoting genes and noncoding RNAs, recently emerged as major governing factors in tumor progression and cancer drug sensitivity. Epigenetic defects (epimutations) are thought to be more easily reversible (when compared with genetic defects) and, as such, have inspired efforts to identify novel compounds that correct epimutations or prevent disease progression. Given the fact that epigenetic modifications occur early in carcinogenesis and represent potentially initiating events in cancer development, they have been identified as promising new targets for chemoprevention strategies. Numerous clinical, epidemiological and laboratory studies have identified various promising nutritional anti-inflammatory compounds as chemopreventive agents, which affect carcinogenic epigenetic marks in the body and the host immune system, and protect against aggressive cancer malignancies. This has recently launched reexploration of chemopreventive phytochemicals for identification of epigenetic targets which allow epigenetic (re)programming of cancer stem cells, prevent metastasis or sensitize for drug sensitivity. This review will discuss mechanisms of epigenome plasticity by cancer-inflammation and chemopreventive phytochemicals.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
book title
Phytochemicals : bioactivities and impact on health
editor
Iraj Rasooli
pages
159 - 198
publisher
InTech
place of publication
Rijeka, Croatia
ISBN
9789533074245
language
English
UGent publication?
yes
classification
B2
copyright statement
I have retained and own the full copyright for this publication
id
2015215
handle
http://hdl.handle.net/1854/LU-2015215
alternative location
http://www.intechopen.com/articles/show/title/phytochemicals-and-cancer-chemoprevention-epigenetic-friends-or-foe-
date created
2012-02-01 16:25:29
date last changed
2012-02-13 17:26:53
@incollection{2015215,
  abstract     = {Cancer, as one of the non-communicable diseases, remains one of the leading causes of death around the world. Since immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and therapy sensitivity. Recent successes of therapeutic interventions in cancer and inflammatory diseases using epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA methylation suggest that epigenetic reprogramming plays an important role in the aetiology of these diseases. Epigenetic changes in DNA methylation patterns at CpG sites (epimutations) or corrupt chromatin states of tumor promoting genes and noncoding RNAs, recently emerged as major governing factors in tumor progression and cancer drug sensitivity.  Epigenetic defects (epimutations) are thought to be more easily reversible (when compared with genetic defects) and, as such, have inspired efforts to identify novel compounds that correct epimutations or prevent disease progression. Given the fact that epigenetic modifications occur early in carcinogenesis and represent potentially initiating events in cancer development, they have been identified as promising new targets for chemoprevention strategies. Numerous clinical, epidemiological and laboratory studies have identified various promising nutritional anti-inflammatory compounds as chemopreventive agents, which affect carcinogenic epigenetic marks in the body and the host immune system, and protect against aggressive cancer malignancies. This has recently launched reexploration of chemopreventive phytochemicals for identification of  epigenetic targets which allow epigenetic (re)programming of cancer stem cells,  prevent metastasis or sensitize for drug sensitivity.  This review will discuss mechanisms of epigenome plasticity by cancer-inflammation and chemopreventive phytochemicals.},
  author       = {Szarc vel Szic, Katarzina and Palagani, Ajay and Hassannia, Behrouz and Sabbe, Linde and Heyninck, Karen and Haegeman, Guy and Vanden Berghe, Wim},
  booktitle    = {Phytochemicals : bioactivities and impact on health},
  editor       = {Rasooli, Iraj},
  isbn         = {9789533074245},
  language     = {eng},
  pages        = {159--198},
  publisher    = {InTech},
  title        = {Phytochemicals and cancer chemoprevention: epigenetic friends or foe?},
  url          = {http://www.intechopen.com/articles/show/title/phytochemicals-and-cancer-chemoprevention-epigenetic-friends-or-foe-},
  year         = {2011},
}

Chicago
Szarc vel Szic, Katarzina, Ajay Palagani, Behrouz Hassannia, Linde Sabbe, Karen Heyninck, Guy Haegeman, and Wim Vanden Berghe. 2011. “Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?” In Phytochemicals : Bioactivities and Impact on Health, ed. Iraj Rasooli, 159–198. Rijeka, Croatia: InTech.
APA
Szarc vel Szic, K., Palagani, A., Hassannia, B., Sabbe, L., Heyninck, K., Haegeman, G., & Vanden Berghe, W. (2011). Phytochemicals and cancer chemoprevention: epigenetic friends or foe? In I. Rasooli (Ed.), Phytochemicals : bioactivities and impact on health (pp. 159–198). Rijeka, Croatia: InTech.
Vancouver
1.
Szarc vel Szic K, Palagani A, Hassannia B, Sabbe L, Heyninck K, Haegeman G, et al. Phytochemicals and cancer chemoprevention: epigenetic friends or foe? In: Rasooli I, editor. Phytochemicals : bioactivities and impact on health. Rijeka, Croatia: InTech; 2011. p. 159–98.
MLA
Szarc vel Szic, Katarzina, Ajay Palagani, Behrouz Hassannia, et al. “Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?” Phytochemicals : Bioactivities and Impact on Health. Ed. Iraj Rasooli. Rijeka, Croatia: InTech, 2011. 159–198. Print.