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Serotonergic descending inhibition in chronic pain: design, preliminary results and early cessation of a randomized controlled trial

(2011) IN VIVO. 25(6). p.1019-1025
Author
Organization
Abstract
AIM: We examined whether activation of serotonergic descending pathways improves pain inhibition during exercise in patients with chronic fatigue syndrome (CFS) and comorbid fibromyalgia (FM) in comparison with rheumatoid arthritis (RA) and sedentary, healthy controls in a double-blind randomized controlled trial with cross-over design. PATIENTS AND METHODS: Three female CFS/FM patients, one female RA patient and two healthy women were randomly allocated to the experimental group (2 ml of citalopram intravenously) or the placebo group (2 ml of 0.9% NaCl intravenously). Participants performed a submaximal exercise protocol, preceded and followed by an assessment of endogenous pain inhibition. Seven days later, groups were crossed over. RESULTS: Significant side-effects were observed in all, but one participant immediately after intravenous administration of citalopram. One CFS/FM patient withdrew because of severe post-exertional malaise. CONCLUSION: It was decided that proceeding with the study would be unethical. No conclusion could be made regarding pain inhibition during exercise in CFS/FM compared to RA and controls.
Keywords
pain inhibition, exercise, chronic pain, chronic fatigue syndrome, Rheumatoid arthritis, citalopram, post-exertional malaise, side-effects

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Chicago
Meeus, Mira, Kelly Ickmans, Luc S De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, and Jo Nijs. 2011. “Serotonergic Descending Inhibition in Chronic Pain: Design, Preliminary Results and Early Cessation of a Randomized Controlled Trial.” In Vivo 25 (6): 1019–1025.
APA
Meeus, M., Ickmans, K., De Clerck, L. S., Moorkens, G., Hans, G., Grosemans, S., & Nijs, J. (2011). Serotonergic descending inhibition in chronic pain: design, preliminary results and early cessation of a randomized controlled trial. IN VIVO, 25(6), 1019–1025.
Vancouver
1.
Meeus M, Ickmans K, De Clerck LS, Moorkens G, Hans G, Grosemans S, et al. Serotonergic descending inhibition in chronic pain: design, preliminary results and early cessation of a randomized controlled trial. IN VIVO. 2011;25(6):1019–25.
MLA
Meeus, Mira, Kelly Ickmans, Luc S De Clerck, et al. “Serotonergic Descending Inhibition in Chronic Pain: Design, Preliminary Results and Early Cessation of a Randomized Controlled Trial.” IN VIVO 25.6 (2011): 1019–1025. Print.
@article{2014598,
  abstract     = {AIM: We examined whether activation of serotonergic descending pathways improves pain inhibition during exercise in patients with chronic fatigue syndrome (CFS) and comorbid fibromyalgia (FM) in comparison with rheumatoid arthritis (RA) and sedentary, healthy controls in a double-blind randomized controlled trial with cross-over design.
PATIENTS AND METHODS: Three female CFS/FM patients, one female RA patient and two healthy women were randomly allocated to the experimental group (2 ml of citalopram intravenously) or the placebo group (2 ml of 0.9\% NaCl intravenously). Participants performed a submaximal exercise protocol, preceded and followed by an assessment of endogenous pain inhibition. Seven days later, groups were crossed over.
RESULTS: Significant side-effects were observed in all, but one participant immediately after intravenous administration of citalopram. One CFS/FM patient withdrew because of severe post-exertional malaise.
CONCLUSION: It was decided that proceeding with the study would be unethical. No conclusion could be made regarding pain inhibition during exercise in CFS/FM compared to RA and controls.},
  author       = {Meeus, Mira and Ickmans, Kelly and De Clerck, Luc S and Moorkens, Greta and Hans, Guy and Grosemans, Sofie  and Nijs, Jo},
  issn         = {0258-851X},
  journal      = {IN VIVO},
  keyword      = {pain inhibition,exercise,chronic pain,chronic fatigue syndrome,Rheumatoid arthritis,citalopram,post-exertional malaise,side-effects},
  language     = {eng},
  number       = {6},
  pages        = {1019--1025},
  title        = {Serotonergic descending inhibition in chronic pain: design, preliminary results and early cessation of a randomized controlled trial},
  url          = {http://iv.iiarjournals.org/content/25/6/1019.abstract},
  volume       = {25},
  year         = {2011},
}