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Catalase-negative peroxisomes in human embryonic liver

Marc Espeel, N Brière, Dirk De Craemer UGent, E Jauniaux and Frank Roels (1993) CELL AND TISSUE RESEARCH. 272(1). p.89-92
abstract
Hepatic peroxisomes in human embryos with a menstrual age of 6 and 7 weeks have been examined via catalase cytochemistry. In the younger sample, the organelles show no catalase activity, their matrix being pale and coarsely reticular. In the 7-week specimen, the peroxisome population consists of catalase-positive and catalase-negative organelles. The latter have a morphology identical to that of the 6-week sample and represent 66% of the population. The positive organelles show a pronounced staining hetereogeneity. Together with the simultaneous presence of negative organelles, this might reflect the onset of catalase import into the peroxisomes during this period. Catalase heterogeneity excludes a continuous exchange of matrix contents; moreover, interconnections between peroxisomes have not been observed, and no cluster formation occurs. The data therefore also suggest that catalase is imported into individual, preexisting organelles in embryonic liver. The three peroxisomal beta-oxidation enzymes become detectable by immunocytochemistry only later during development. Morphological indications for a rapidly dividing population, such as elongated and/or tailed organelles, have not been observed. Morphometry has revealed that, in these early stages, the organelles are significantly smaller than the peroxisomes of fetal and adult human liver.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ENZYMES, PEROXISOMES, OXIDASE, SIZE, SECTIONS, RAT-LIVER, LIVER, DEVELOPMENT, FETAL, HEPATOCELLULAR PEROXISOMES, CATALASE, BIOGENESIS, MAN
journal title
CELL AND TISSUE RESEARCH
Cell Tissue Res.
volume
272
issue
1
pages
89-92 pages
Web of Science type
Article
ISSN
0302-766X
DOI
10.1007/BF00323574
language
English
UGent publication?
no
classification
A1
id
201196
handle
http://hdl.handle.net/1854/LU-201196
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:38:50
@article{201196,
  abstract     = {Hepatic peroxisomes in human embryos with a menstrual age of 6 and 7 weeks have been examined via catalase cytochemistry. In the younger sample, the organelles show no catalase activity, their matrix being pale and coarsely reticular. In the 7-week specimen, the peroxisome population consists of catalase-positive and catalase-negative organelles. The latter have a morphology identical to that of the 6-week sample and represent 66\% of the population. The positive organelles show a pronounced staining hetereogeneity. Together with the simultaneous presence of negative organelles, this might reflect the onset of catalase import into the peroxisomes during this period. Catalase heterogeneity excludes a continuous exchange of matrix contents; moreover, interconnections between peroxisomes have not been observed, and no cluster formation occurs. The data therefore also suggest that catalase is imported into individual, preexisting organelles in embryonic liver. The three peroxisomal beta-oxidation enzymes become detectable by immunocytochemistry only later during development. Morphological indications for a rapidly dividing population, such as elongated and/or tailed organelles, have not been observed. Morphometry has revealed that, in these early stages, the organelles are significantly smaller than the peroxisomes of fetal and adult human liver.},
  author       = {Espeel, Marc and Bri{\`e}re, N and De Craemer, Dirk and Jauniaux, E and Roels, Frank},
  issn         = {0302-766X},
  journal      = {CELL AND TISSUE RESEARCH},
  keyword      = {ENZYMES,PEROXISOMES,OXIDASE,SIZE,SECTIONS,RAT-LIVER,LIVER,DEVELOPMENT,FETAL,HEPATOCELLULAR PEROXISOMES,CATALASE,BIOGENESIS,MAN},
  language     = {eng},
  number       = {1},
  pages        = {89--92},
  title        = {Catalase-negative peroxisomes in human embryonic liver},
  url          = {http://dx.doi.org/10.1007/BF00323574},
  volume       = {272},
  year         = {1993},
}

Chicago
Espeel, Marc, N Brière, Dirk De Craemer, E Jauniaux, and Frank Roels. 1993. “Catalase-negative Peroxisomes in Human Embryonic Liver.” Cell and Tissue Research 272 (1): 89–92.
APA
Espeel, M., Brière, N., De Craemer, D., Jauniaux, E., & Roels, F. (1993). Catalase-negative peroxisomes in human embryonic liver. CELL AND TISSUE RESEARCH, 272(1), 89–92.
Vancouver
1.
Espeel M, Brière N, De Craemer D, Jauniaux E, Roels F. Catalase-negative peroxisomes in human embryonic liver. CELL AND TISSUE RESEARCH. 1993;272(1):89–92.
MLA
Espeel, Marc, N Brière, Dirk De Craemer, et al. “Catalase-negative Peroxisomes in Human Embryonic Liver.” CELL AND TISSUE RESEARCH 272.1 (1993): 89–92. Print.