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Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study

Mira Meeus UGent, Jo Nijs, Sven Huybrechts and Steven Truijen (2010) CLINICAL RHEUMATOLOGY. 29(4). p.393-398
abstract
Several studies provided evidence for generalized hyperalgesia in fibromyalgia or whiplash-associated disorders. In chronic fatigue syndrome, however, pain is a frequently reported complaint, but up to now, evidence for generalized hyperalgesia is lacking. The aim of this study is to examine whether the pressure pain thresholds (PPTs) at both symptomatic and asymptomatic sites differ in chronic fatigue syndrome (CFS) patients with chronic pain, compared to healthy controls. Therefore, 30 CFS patients with chronic pain and 30 age- and gender-matched healthy controls indicated on a Margolis Pain Diagram where they felt pain lasting longer than 24 h in the past 4 weeks. After completing a test battery of questionnaires evaluating pain cognitions, functional status and symptomatology, a blinded researcher assessed PPTs bilaterally at seven nonspecific sites on both trunk and extremities. PPTs were compared for the two complete groups. In addition, PPTs of patients and controls who did not report pain in a respective zone were compared. PPTs of the patients were significantly lower (p<0.001) compared to those of the control group, also when pain-free samples per zone were compared (p<0.001). The mean PPT was 3.30 kg/cm2 in all CFS patients and 8.09 kg/cm2 in the controls. No confounding factors responsible for the observed differences, as, e.g., catastrophizing and depression, could be revealed. These findings provide evidence for the existence of hyperalgesia even in asymptomatic areas (generalized secondary hyperalgesia). The generalized hyperalgesia may represent the involvement of a sensitized central nervous system.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
hyperalgesia, algometry, central sensitization, chronic fatigue syndrome, chronic pain
journal title
CLINICAL RHEUMATOLOGY
Clin. Rheumatol.
volume
29
issue
4
pages
393 - 398
Web of Science type
Article
Web of Science id
000275153800009
JCR category
RHEUMATOLOGY
JCR impact factor
1.687 (2010)
JCR rank
20/29 (2010)
JCR quartile
3 (2010)
ISSN
0770-3198
DOI
10.1007/s10067-009-1339-0
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2010747
handle
http://hdl.handle.net/1854/LU-2010747
date created
2012-02-01 09:22:17
date last changed
2016-12-19 15:45:09
@article{2010747,
  abstract     = {Several studies provided evidence for generalized hyperalgesia in fibromyalgia or whiplash-associated disorders. In chronic fatigue syndrome, however, pain is a frequently reported complaint, but up to now, evidence for generalized hyperalgesia is lacking. The aim of this study is to examine whether the pressure pain thresholds (PPTs) at both symptomatic and asymptomatic sites differ in chronic fatigue syndrome (CFS) patients with chronic pain, compared to healthy controls. Therefore, 30 CFS patients with chronic pain and 30 age- and gender-matched healthy controls indicated on a Margolis Pain Diagram where they felt pain lasting longer than 24 h in the past 4 weeks. After completing a test battery of questionnaires evaluating pain cognitions, functional status and symptomatology, a blinded researcher assessed PPTs bilaterally at seven nonspecific sites on both trunk and extremities. PPTs were compared for the two complete groups. In addition, PPTs of patients and controls who did not report pain in a respective zone were compared. PPTs of the patients were significantly lower (p{\textlangle}0.001) compared to those of the control group, also when pain-free samples per zone were compared (p{\textlangle}0.001). The mean PPT was 3.30 kg/cm2 in all CFS patients and 8.09 kg/cm2 in the controls. No confounding factors responsible for the observed differences, as, e.g., catastrophizing and depression, could be revealed. These findings provide evidence for the existence of hyperalgesia even in asymptomatic areas (generalized secondary hyperalgesia). The generalized hyperalgesia may represent the involvement of a sensitized central nervous system.},
  author       = {Meeus, Mira and Nijs, Jo and Huybrechts, Sven and Truijen, Steven},
  issn         = {0770-3198},
  journal      = {CLINICAL RHEUMATOLOGY},
  keyword      = {hyperalgesia,algometry,central sensitization,chronic fatigue syndrome,chronic pain},
  language     = {eng},
  number       = {4},
  pages        = {393--398},
  title        = {Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study},
  url          = {http://dx.doi.org/10.1007/s10067-009-1339-0},
  volume       = {29},
  year         = {2010},
}

Chicago
Meeus, Mira, Jo Nijs, Sven Huybrechts, and Steven Truijen. 2010. “Evidence for Generalized Hyperalgesia in Chronic Fatigue Syndrome: a Case Control Study.” Clinical Rheumatology 29 (4): 393–398.
APA
Meeus, M., Nijs, J., Huybrechts, S., & Truijen, S. (2010). Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study. CLINICAL RHEUMATOLOGY, 29(4), 393–398.
Vancouver
1.
Meeus M, Nijs J, Huybrechts S, Truijen S. Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study. CLINICAL RHEUMATOLOGY. 2010;29(4):393–8.
MLA
Meeus, Mira, Jo Nijs, Sven Huybrechts, et al. “Evidence for Generalized Hyperalgesia in Chronic Fatigue Syndrome: a Case Control Study.” CLINICAL RHEUMATOLOGY 29.4 (2010): 393–398. Print.