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Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance

(2008) IN VIVO. 22(1). p.115-121
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Abstract
This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (r(s)=0.570; p=0.021), protein kinase R (PKR) (r(s)=0.716; p = 0. 002) and elastase activity (r(s) = 0. 500; p = 0. 049). RNase L activity was related to elastase (r(s)=0.547; p=0.028) and PKR activity (r(s)=0.625; p=0.010). RNase L activity (r(s)=0.535; p=0.033), elastase activity (r(s)=0.585; p=0.017) and RNase L cleavage (r(s)=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.
Keywords
NO, immunity, PKR, RNase L, chronic fatigue syndrome, elastase, exercise capacity, daily functioning, ELEVATED NITRIC OXIDE/PEROXYNITRITE, MULTIPLE CHEMICAL-SENSITIVITY, BLOOD MONONUCLEAR-CELLS, NF-KAPPA-B, EXERCISE CAPACITY, OXIDE PRODUCTION, ACTIVATION, PERFORMANCE, DEFINITION, INFECTION

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Citation

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Chicago
Meeus, Mira, Jo Nijs, Neil MvGregor, Romain Meeusen, Guy De Schutter, Steven Truijen, Marc Frémont, Elke Van Hoof, and Kenny De Meirleir. 2008. “Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions Between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity and Their Clinical Relevance.” In Vivo 22 (1): 115–121.
APA
Meeus, M., Nijs, J., MvGregor, N., Meeusen, R., De Schutter, G., Truijen, S., Frémont, M., et al. (2008). Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance. IN VIVO, 22(1), 115–121.
Vancouver
1.
Meeus M, Nijs J, MvGregor N, Meeusen R, De Schutter G, Truijen S, et al. Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance. IN VIVO. 2008;22(1):115–21.
MLA
Meeus, Mira, Jo Nijs, Neil MvGregor, et al. “Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions Between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity and Their Clinical Relevance.” IN VIVO 22.1 (2008): 115–121. Print.
@article{2010483,
  abstract     = {This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (r(s)=0.570; p=0.021), protein kinase R (PKR) (r(s)=0.716; p = 0. 002) and elastase activity (r(s) = 0. 500; p = 0. 049). RNase L activity was related to elastase (r(s)=0.547; p=0.028) and PKR activity (r(s)=0.625; p=0.010). RNase L activity (r(s)=0.535; p=0.033), elastase activity (r(s)=0.585; p=0.017) and RNase L cleavage (r(s)=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.},
  author       = {Meeus, Mira and Nijs, Jo and MvGregor, Neil and Meeusen, Romain and De Schutter, Guy and Truijen, Steven and Fr{\'e}mont, Marc and Van Hoof, Elke and De Meirleir, Kenny},
  issn         = {0258-851X},
  journal      = {IN VIVO},
  keyword      = {NO,immunity,PKR,RNase L,chronic fatigue syndrome,elastase,exercise capacity,daily functioning,ELEVATED NITRIC OXIDE/PEROXYNITRITE,MULTIPLE CHEMICAL-SENSITIVITY,BLOOD MONONUCLEAR-CELLS,NF-KAPPA-B,EXERCISE CAPACITY,OXIDE PRODUCTION,ACTIVATION,PERFORMANCE,DEFINITION,INFECTION},
  language     = {eng},
  number       = {1},
  pages        = {115--121},
  title        = {Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance},
  url          = {http://iv.iiarjournals.org/content/22/1/115.long},
  volume       = {22},
  year         = {2008},
}

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