Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance
- Author
- Mira Meeus (UGent) , Jo Nijs, Neil MvGregor, Romain Meeusen, Guy De Schutter, Steven Truijen, Marc Frémont, Elke Van Hoof and Kenny De Meirleir
- Organization
- Abstract
- This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (r(s)=0.570; p=0.021), protein kinase R (PKR) (r(s)=0.716; p = 0. 002) and elastase activity (r(s) = 0. 500; p = 0. 049). RNase L activity was related to elastase (r(s)=0.547; p=0.028) and PKR activity (r(s)=0.625; p=0.010). RNase L activity (r(s)=0.535; p=0.033), elastase activity (r(s)=0.585; p=0.017) and RNase L cleavage (r(s)=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.
- Keywords
- NO, immunity, PKR, RNase L, chronic fatigue syndrome, elastase, exercise capacity, daily functioning, ELEVATED NITRIC OXIDE/PEROXYNITRITE, MULTIPLE CHEMICAL-SENSITIVITY, BLOOD MONONUCLEAR-CELLS, NF-KAPPA-B, EXERCISE CAPACITY, OXIDE PRODUCTION, ACTIVATION, PERFORMANCE, DEFINITION, INFECTION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-2010483
- MLA
- Meeus, Mira, et al. “Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity and Their Clinical Relevance.” IN VIVO, vol. 22, no. 1, 2008, pp. 115–21.
- APA
- Meeus, M., Nijs, J., MvGregor, N., Meeusen, R., De Schutter, G., Truijen, S., … De Meirleir, K. (2008). Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance. IN VIVO, 22(1), 115–121.
- Chicago author-date
- Meeus, Mira, Jo Nijs, Neil MvGregor, Romain Meeusen, Guy De Schutter, Steven Truijen, Marc Frémont, Elke Van Hoof, and Kenny De Meirleir. 2008. “Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity and Their Clinical Relevance.” IN VIVO 22 (1): 115–21.
- Chicago author-date (all authors)
- Meeus, Mira, Jo Nijs, Neil MvGregor, Romain Meeusen, Guy De Schutter, Steven Truijen, Marc Frémont, Elke Van Hoof, and Kenny De Meirleir. 2008. “Unravelling Intracellular Immune Dysfunctions in Chronic Fatigue Syndrome: Interactions between Protein Kinase R Activity, RNase L Cleavage and Elastase Activity and Their Clinical Relevance.” IN VIVO 22 (1): 115–121.
- Vancouver
- 1.Meeus M, Nijs J, MvGregor N, Meeusen R, De Schutter G, Truijen S, et al. Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance. IN VIVO. 2008;22(1):115–21.
- IEEE
- [1]M. Meeus et al., “Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance,” IN VIVO, vol. 22, no. 1, pp. 115–121, 2008.
@article{2010483, abstract = {{This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (r(s)=0.570; p=0.021), protein kinase R (PKR) (r(s)=0.716; p = 0. 002) and elastase activity (r(s) = 0. 500; p = 0. 049). RNase L activity was related to elastase (r(s)=0.547; p=0.028) and PKR activity (r(s)=0.625; p=0.010). RNase L activity (r(s)=0.535; p=0.033), elastase activity (r(s)=0.585; p=0.017) and RNase L cleavage (r(s)=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.}}, author = {{Meeus, Mira and Nijs, Jo and MvGregor, Neil and Meeusen, Romain and De Schutter, Guy and Truijen, Steven and Frémont, Marc and Van Hoof, Elke and De Meirleir, Kenny}}, issn = {{0258-851X}}, journal = {{IN VIVO}}, keywords = {{NO,immunity,PKR,RNase L,chronic fatigue syndrome,elastase,exercise capacity,daily functioning,ELEVATED NITRIC OXIDE/PEROXYNITRITE,MULTIPLE CHEMICAL-SENSITIVITY,BLOOD MONONUCLEAR-CELLS,NF-KAPPA-B,EXERCISE CAPACITY,OXIDE PRODUCTION,ACTIVATION,PERFORMANCE,DEFINITION,INFECTION}}, language = {{eng}}, number = {{1}}, pages = {{115--121}}, title = {{Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity and their clinical relevance}}, url = {{http://iv.iiarjournals.org/content/22/1/115.long}}, volume = {{22}}, year = {{2008}}, }