Advanced search
1 file | 328.20 KB

Which method of estimating renal function is the best predictor of mortality after coronary artery bypass grafting?

(2011) NETHERLANDS HEART JOURNAL. 19(11). p.464-469
Author
Organization
Abstract
Objectives Definitions of renal function in patients undergoing coronary artery bypass graft surgery (CABG) vary in the literature. We sought to investigate which method of estimating renal function is the best predictor of mortality after CABG. Methods We analysed the preoperative and postoperative renal function data from all patients undergoing isolated CABG from January 1998 through December 2007. Preoperative and postoperative renal function was estimated using serum creatinine (SeCr) levels, creatinine clearance (CrCl) determined by the Cockcroft-Gault formula and the glomerular filtration rate (e-GFR) estimated by the Modification of Diet in Renal Disease (MDRD) formula. Receiver operator characteristic (ROC) curves and area under the ROC curves were calculated. Results In 9987 patients, CrCl had the best discriminatory power to predict early as well as late mortality, followed by e-GFR and finally SeCr. The odds ratios for preoperative parameters for early mortality were closer to 1 than those of the postoperative parameters. Conclusions Renal function determined by the Cockcroft-Gault formula is the best predictor of early and late mortality after CABG. The relationship between renal function and mortality is non-linear. Renal function as a variable in risk scoring systems such as the EuroSCORE needs to be reconsidered.
Keywords
renal function, Statistics, Kidney, CABG, Coronary artery bypass grafts, regression analysis, GLOMERULAR-FILTRATION-RATE, CHRONIC KIDNEY-DISEASE, EUROSCORE MULTINATIONAL DATABASE, EUROPEAN CARDIAC-SURGERY, LONG-TERM SURVIVAL, SERUM CREATININE, RISK-FACTORS, DYSFUNCTION, CLEARANCE, OUTCOMES

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 328.20 KB

Citation

Please use this url to cite or link to this publication:

Chicago
van Straten, AHM, MAS Hamad, BMJA Koene, EJ Martens, MESH Tan, E Berreklouw, and Adrien Van Zundert. 2011. “Which Method of Estimating Renal Function Is the Best Predictor of Mortality After Coronary Artery Bypass Grafting?” Netherlands Heart Journal 19 (11): 464–469.
APA
van Straten, AHM, Hamad, M., Koene, B., Martens, E., Tan, M., Berreklouw, E., & Van Zundert, A. (2011). Which method of estimating renal function is the best predictor of mortality after coronary artery bypass grafting? NETHERLANDS HEART JOURNAL, 19(11), 464–469.
Vancouver
1.
van Straten A, Hamad M, Koene B, Martens E, Tan M, Berreklouw E, et al. Which method of estimating renal function is the best predictor of mortality after coronary artery bypass grafting? NETHERLANDS HEART JOURNAL. 2011;19(11):464–9.
MLA
van Straten, AHM, MAS Hamad, BMJA Koene, et al. “Which Method of Estimating Renal Function Is the Best Predictor of Mortality After Coronary Artery Bypass Grafting?” NETHERLANDS HEART JOURNAL 19.11 (2011): 464–469. Print.
@article{2009939,
  abstract     = {Objectives Definitions of renal function in patients undergoing coronary artery bypass graft surgery (CABG) vary in the literature. We sought to investigate which method of estimating renal function is the best predictor of mortality after CABG. 
Methods We analysed the preoperative and postoperative renal function data from all patients undergoing isolated CABG from January 1998 through December 2007. Preoperative and postoperative renal function was estimated using serum creatinine (SeCr) levels, creatinine clearance (CrCl) determined by the Cockcroft-Gault formula and the glomerular filtration rate (e-GFR) estimated by the Modification of Diet in Renal Disease (MDRD) formula. Receiver operator characteristic (ROC) curves and area under the ROC curves were calculated. 
Results In 9987 patients, CrCl had the best discriminatory power to predict early as well as late mortality, followed by e-GFR and finally SeCr. The odds ratios for preoperative parameters for early mortality were closer to 1 than those of the postoperative parameters. 
Conclusions Renal function determined by the Cockcroft-Gault formula is the best predictor of early and late mortality after CABG. The relationship between renal function and mortality is non-linear. Renal function as a variable in risk scoring systems such as the EuroSCORE needs to be reconsidered.},
  author       = {van Straten, AHM and Hamad, MAS and Koene, BMJA and Martens, EJ and Tan, MESH and Berreklouw, E and Van Zundert, Adrien},
  issn         = {1568-5888},
  journal      = {NETHERLANDS HEART JOURNAL},
  keywords     = {renal function,Statistics,Kidney,CABG,Coronary artery bypass grafts,regression analysis,GLOMERULAR-FILTRATION-RATE,CHRONIC KIDNEY-DISEASE,EUROSCORE MULTINATIONAL DATABASE,EUROPEAN CARDIAC-SURGERY,LONG-TERM SURVIVAL,SERUM CREATININE,RISK-FACTORS,DYSFUNCTION,CLEARANCE,OUTCOMES},
  language     = {eng},
  number       = {11},
  pages        = {464--469},
  title        = {Which method of estimating renal function is the best predictor of mortality after coronary artery bypass grafting?},
  url          = {http://dx.doi.org/10.1007/s12471-011-0184-3},
  volume       = {19},
  year         = {2011},
}

Altmetric
View in Altmetric
Web of Science
Times cited: