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Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission

(2012) JOURNAL OF INFECTIOUS DISEASES. 205(2). p.174-184
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Abstract
Background. The prevalence and correlates of CXCR4-use in recently diagnosed patients and the impact of X4/DM transmission remain largely unknown. Method. Genotypic coreceptor use determination on the baseline sample of 539 recently diagnosed individuals. Correlation of coreceptor use with clinical, viral and epidemiological data and with information on transmission events as obtained through phylogenetic analysis of protease and reverse transcriptase sequences. Results. CXCR4-use was predicted in 12 to 19% of the patients, depending on the interpretative cutoff used. CXCR4-use was correlated with lower CD4(+) T cell counts and subtype 01_AE infection. No association with viral load was observed. Seven (11%) of 63 transmission clusters and 4 (31%) of 13 donor-source pairs resulted from X4/DM transmission. Conclusion. The results confirmed the relation between CXCR4-use at diagnosis and low baseline CD4+ T cell counts. Significantly more CXCR4-use was predicted in 01_AE infections, which may impose constraints on the use of CCR5 antagonists in certain regions of the world. Observations from the transmission cluster analysis contradict the hypothesis that R5 viruses are selected at transmission, and support the idea that R5 or X4/DM infections result from a stochastic process.
Keywords
TROPISM, HUMAN-IMMUNODEFICIENCY-VIRUS, INDIVIDUALS, CCR5, EXPERIENCED PATIENTS, GENETIC SUBTYPES, SUBTYPE-C, BIOLOGICAL PHENOTYPE, CORECEPTOR USAGE, DRUG-RESISTANCE

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Citation

Please use this url to cite or link to this publication:

Chicago
Chalmet, Kristen, Kenny Dauwe, Lander Foquet, Franky Baatz, Carole Seguin-Devaux, Beatrijs Van Der Gucht, Dirk Vogelaers, Linos Vandekerckhove, Jean Plum, and Chris Verhofstede. 2012. “Presence of CXCR4-using HIV-1 in Patients with Recently Diagnosed Infection: Correlates and Evidence for Transmission.” Journal of Infectious Diseases 205 (2): 174–184.
APA
Chalmet, K., Dauwe, K., Foquet, L., Baatz, F., Seguin-Devaux, C., Van Der Gucht, B., Vogelaers, D., et al. (2012). Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission. JOURNAL OF INFECTIOUS DISEASES, 205(2), 174–184.
Vancouver
1.
Chalmet K, Dauwe K, Foquet L, Baatz F, Seguin-Devaux C, Van Der Gucht B, et al. Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission. JOURNAL OF INFECTIOUS DISEASES. 2012;205(2):174–84.
MLA
Chalmet, Kristen, Kenny Dauwe, Lander Foquet, et al. “Presence of CXCR4-using HIV-1 in Patients with Recently Diagnosed Infection: Correlates and Evidence for Transmission.” JOURNAL OF INFECTIOUS DISEASES 205.2 (2012): 174–184. Print.
@article{2009262,
  abstract     = {Background. The prevalence and correlates of CXCR4-use in recently diagnosed patients and the impact of X4/DM transmission remain largely unknown. 
Method. Genotypic coreceptor use determination on the baseline sample of 539 recently diagnosed individuals. Correlation of coreceptor use with clinical, viral and epidemiological data and with information on transmission events as obtained through phylogenetic analysis of protease and reverse transcriptase sequences. 
Results. CXCR4-use was predicted in 12 to 19\% of the patients, depending on the interpretative cutoff used. CXCR4-use was correlated with lower CD4(+) T cell counts and subtype 01\_AE infection. No association with viral load was observed. Seven (11\%) of 63 transmission clusters and 4 (31\%) of 13 donor-source pairs resulted from X4/DM transmission. 
Conclusion. The results confirmed the relation between CXCR4-use at diagnosis and low baseline CD4+ T cell counts. Significantly more CXCR4-use was predicted in 01\_AE infections, which may impose constraints on the use of CCR5 antagonists in certain regions of the world. Observations from the transmission cluster analysis contradict the hypothesis that R5 viruses are selected at transmission, and support the idea that R5 or X4/DM infections result from a stochastic process.},
  author       = {Chalmet, Kristen and Dauwe, Kenny and Foquet, Lander and Baatz, Franky and Seguin-Devaux, Carole and Van Der Gucht, Beatrijs and Vogelaers, Dirk and Vandekerckhove, Linos and Plum, Jean and Verhofstede, Chris},
  issn         = {0022-1899},
  journal      = {JOURNAL OF INFECTIOUS DISEASES},
  language     = {eng},
  number       = {2},
  pages        = {174--184},
  title        = {Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission},
  url          = {http://dx.doi.org/10.1093/infdis/jir714},
  volume       = {205},
  year         = {2012},
}

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