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Muscarinic receptor subtypes, beta-adrenoceptors and camp in the tracheal smooth-muscle of conventional and double-muscled calves.

E Roets, Christian Paul G. Burvenich (UGent) and M Roberts
(1992) VETERINARY RESEARCH COMMUNICATIONS. 16(6). p.465-476
Author
Organization
Abstract
The total muscarinic (M1 + M2 + M3) and beta-adrenergic receptors in the tracheal smooth muscle of conventional and double-muscled calves were identified and characterized with the non-specific antagonists [H-3]quinuclidinyl benzilate ([H-3]QNB) and [H-3]dihydroalprenolol ([H-3]DHA) respectively. Although the quantity of beta-adrenoceptors in double-muscled calves was 25% lower (p < 0.05) than in conventional calves (Bmax = 327 +/- 89 fmol/mg protein), adenylate cyclase assays indicated that the basal adenylate cyclase activity and the (-)-isopropylnoradrenaline (ISO)- and sodium fluoride (NaF)-stimulated values were not significantly different between these calves. However, the density of muscarinic receptors in double-muscled calves was 40% higher (p < 0.01) than in conventional calves (Bmax = 2955 +/- 625 fmol/mg protein). Subtypes of muscarinic receptors were studied with [H-3]telenzepine (M1-receptors), [H-3]AF-DX 384 (M2-receptors) and [H-3]4DAMP (M1 and M3-receptors). It was found that in both double-muscled and conventional calves about 40% of the receptors were of the M3-subtype, the remaining 60% being M2-receptors. From these results,it is suggested that inflammation of the respiratory tract in double-muscled calves may be complicated by an imbalance between the cholinergic bronchoconstrictor and the beta-adrenergic bronchodilator components of the autonomic nervous system.
Keywords
DOUBLE-MUSCLED CALVES, MUSCARINIC RECEPTORS, BETA-ADRENOCEPTORS, TRACHEA, CHOLINERGIC RECEPTORS, MUCOSA, ADRENERGIC RECEPTORS, MEMBRANES, SMOOTH MUSCLE

Citation

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MLA
Roets, E., et al. “Muscarinic Receptor Subtypes, Beta-Adrenoceptors and Camp in the Tracheal Smooth-Muscle of Conventional and Double-Muscled Calves.” VETERINARY RESEARCH COMMUNICATIONS, vol. 16, no. 6, 1992, pp. 465–76, doi:10.1007/BF01839024.
APA
Roets, E., Burvenich, C. P. G., & Roberts, M. (1992). Muscarinic receptor subtypes, beta-adrenoceptors and camp in the tracheal smooth-muscle of conventional and double-muscled calves. VETERINARY RESEARCH COMMUNICATIONS, 16(6), 465–476. https://doi.org/10.1007/BF01839024
Chicago author-date
Roets, E, Christian Paul G. Burvenich, and M Roberts. 1992. “Muscarinic Receptor Subtypes, Beta-Adrenoceptors and Camp in the Tracheal Smooth-Muscle of Conventional and Double-Muscled Calves.” VETERINARY RESEARCH COMMUNICATIONS 16 (6): 465–76. https://doi.org/10.1007/BF01839024.
Chicago author-date (all authors)
Roets, E, Christian Paul G. Burvenich, and M Roberts. 1992. “Muscarinic Receptor Subtypes, Beta-Adrenoceptors and Camp in the Tracheal Smooth-Muscle of Conventional and Double-Muscled Calves.” VETERINARY RESEARCH COMMUNICATIONS 16 (6): 465–476. doi:10.1007/BF01839024.
Vancouver
1.
Roets E, Burvenich CPG, Roberts M. Muscarinic receptor subtypes, beta-adrenoceptors and camp in the tracheal smooth-muscle of conventional and double-muscled calves. VETERINARY RESEARCH COMMUNICATIONS. 1992;16(6):465–76.
IEEE
[1]
E. Roets, C. P. G. Burvenich, and M. Roberts, “Muscarinic receptor subtypes, beta-adrenoceptors and camp in the tracheal smooth-muscle of conventional and double-muscled calves.,” VETERINARY RESEARCH COMMUNICATIONS, vol. 16, no. 6, pp. 465–476, 1992.
@article{200903,
  abstract     = {{The total muscarinic (M1 + M2 + M3) and beta-adrenergic receptors in the tracheal smooth muscle of conventional and double-muscled calves were identified and characterized with the non-specific antagonists [H-3]quinuclidinyl benzilate ([H-3]QNB) and [H-3]dihydroalprenolol ([H-3]DHA) respectively. Although the quantity of beta-adrenoceptors in double-muscled calves was 25% lower (p < 0.05) than in conventional calves (Bmax = 327 +/- 89 fmol/mg protein), adenylate cyclase assays indicated that the basal adenylate cyclase activity and the (-)-isopropylnoradrenaline (ISO)- and sodium fluoride (NaF)-stimulated values were not significantly different between these calves. However, the density of muscarinic receptors in double-muscled calves was 40% higher (p < 0.01) than in conventional calves (Bmax = 2955 +/- 625 fmol/mg protein). Subtypes of muscarinic receptors were studied with [H-3]telenzepine (M1-receptors), [H-3]AF-DX 384 (M2-receptors) and [H-3]4DAMP (M1 and M3-receptors). It was found that in both double-muscled and conventional calves about 40% of the receptors were of the M3-subtype, the remaining 60% being M2-receptors. From these results,it is suggested that inflammation of the respiratory tract in double-muscled calves may be complicated by an imbalance between the cholinergic bronchoconstrictor and the beta-adrenergic bronchodilator components of the autonomic nervous system.}},
  author       = {{Roets, E and Burvenich, Christian Paul G. and Roberts, M}},
  issn         = {{0165-7380}},
  journal      = {{VETERINARY RESEARCH COMMUNICATIONS}},
  keywords     = {{DOUBLE-MUSCLED CALVES,MUSCARINIC RECEPTORS,BETA-ADRENOCEPTORS,TRACHEA,CHOLINERGIC RECEPTORS,MUCOSA,ADRENERGIC RECEPTORS,MEMBRANES,SMOOTH MUSCLE}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{465--476}},
  title        = {{Muscarinic receptor subtypes, beta-adrenoceptors and camp in the tracheal smooth-muscle of conventional and double-muscled calves.}},
  url          = {{http://doi.org/10.1007/BF01839024}},
  volume       = {{16}},
  year         = {{1992}},
}
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