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The microRNA body map: dissecting microRNA function through integrative genomics

Pieter Mestdagh UGent, Steve Lefever UGent, Filip Pattyn UGent, Dana Ridzon, Erik Fredlund, Annelies Fieuw UGent, Maté Ongenaert UGent, Joëlle Vermeulen UGent, Anne De Paepe UGent and Linda Wong, et al. (2011) NUCLEIC ACIDS RESEARCH. 39(20).
abstract
While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of corresponding miRNA and mRNA gene expression levels, miRNA target prediction, transcription factor target prediction and mechanistic models of gene network regulation. Predicted miRNA functions were either validated experimentally or compared to published data. The predicted miRNA functions are accessible in the miRNA bodymap, an interactive online compendium and mining tool of high-dimensional newly generated and published miRNA expression profiles. The miRNA bodymap enables prioritization of candidate miRNAs based on their expression pattern or functional annotation across tissue or disease subgroup. The miRNA bodymap project provides users with a single one-stop data-mining solution and has great potential to become a community resource.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TUMORS, CLUSTER, PREDICTION, EXPRESSION, ANNOTATION, DISEASE, TRANSITION
journal title
NUCLEIC ACIDS RESEARCH
Nucleic Acids Res.
volume
39
issue
20
article_number
e136
pages
8 pages
Web of Science type
Article
Web of Science id
000296343400005
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
8.026 (2011)
JCR rank
26/286 (2011)
JCR quartile
1 (2011)
ISSN
0305-1048
DOI
10.1093/nar/gkr646
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
2008769
handle
http://hdl.handle.net/1854/LU-2008769
date created
2012-01-31 10:27:34
date last changed
2013-02-27 09:11:13
@article{2008769,
  abstract     = {While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of corresponding miRNA and mRNA gene expression levels, miRNA target prediction, transcription factor target prediction and mechanistic models of gene network regulation. Predicted miRNA functions were either validated experimentally or compared to published data. The predicted miRNA functions are accessible in the miRNA bodymap, an interactive online compendium and mining tool of high-dimensional newly generated and published miRNA expression profiles. The miRNA bodymap enables prioritization of candidate miRNAs based on their expression pattern or functional annotation across tissue or disease subgroup. The miRNA bodymap project provides users with a single one-stop data-mining solution and has great potential to become a community resource.},
  articleno    = {e136},
  author       = {Mestdagh, Pieter and Lefever, Steve and Pattyn, Filip and Ridzon, Dana and Fredlund, Erik and Fieuw, Annelies and Ongenaert, Mat{\'e} and Vermeulen, Jo{\"e}lle and De Paepe, Anne and Wong, Linda and Speleman, Franki and Chen, CaiFu and Vandesompele, Jo},
  issn         = {0305-1048},
  journal      = {NUCLEIC ACIDS RESEARCH},
  keyword      = {TUMORS,CLUSTER,PREDICTION,EXPRESSION,ANNOTATION,DISEASE,TRANSITION},
  language     = {eng},
  number       = {20},
  pages        = {8},
  title        = {The microRNA body map: dissecting microRNA function through integrative genomics},
  url          = {http://dx.doi.org/10.1093/nar/gkr646},
  volume       = {39},
  year         = {2011},
}

Chicago
Mestdagh, Pieter, Steve Lefever, Filip Pattyn, Dana Ridzon, Erik Fredlund, Annelies Fieuw, Maté Ongenaert, et al. 2011. “The microRNA Body Map: Dissecting microRNA Function Through Integrative Genomics.” Nucleic Acids Research 39 (20).
APA
Mestdagh, P., Lefever, S., Pattyn, F., Ridzon, D., Fredlund, E., Fieuw, A., Ongenaert, M., et al. (2011). The microRNA body map: dissecting microRNA function through integrative genomics. NUCLEIC ACIDS RESEARCH, 39(20).
Vancouver
1.
Mestdagh P, Lefever S, Pattyn F, Ridzon D, Fredlund E, Fieuw A, et al. The microRNA body map: dissecting microRNA function through integrative genomics. NUCLEIC ACIDS RESEARCH. 2011;39(20).
MLA
Mestdagh, Pieter, Steve Lefever, Filip Pattyn, et al. “The microRNA Body Map: Dissecting microRNA Function Through Integrative Genomics.” NUCLEIC ACIDS RESEARCH 39.20 (2011): n. pag. Print.