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Recombinant plant made antibodies against fimbriae of enterotoxigenic Escherichia coli inhibit in vitro binding to villous enterocytes

Vikram Virdi (UGent) , Sylvie De Buck (UGent) , Annelies Coddens (UGent) , Bruno Goddeeris (UGent) , Eric Cox (UGent) , Henri De Greve and Anna Depicker (UGent)
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Abstract
Plants can be used to produce a plethora of recombinant therapeutic proteins at fraction of a cost as compared to conventional production platforms. Plant seeds in particular are natural protein producing and storage organs, which enable production of abundant recombinant protein in stable confined environment. The seed based expression system is particularly interesting for oral passive immunisation against veterinarian diseases, such as enterotoxigenic Escherichia coli (ETEC) causing post weaning diarrhoea. We therefore investigated the production of anti-ETEC antibodies in seeds of the model plant Arabidopsis thaliana, to later transfer the technology to a grain crop that can be used in piglet starter feed and produced in sufficient quantities.

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Chicago
Virdi, Vikram, Sylvie De Buck, Annelies Coddens, Bruno Goddeeris, Eric Cox, Henri De Greve, and Anna Depicker. 2011. “Recombinant Plant Made Antibodies Against Fimbriae of Enterotoxigenic Escherichia Coli Inhibit in Vitro Binding to Villous Enterocytes.” In ECMIS, Abstracts.
APA
Virdi, V., De Buck, S., Coddens, A., Goddeeris, B., Cox, E., De Greve, H., & Depicker, A. (2011). Recombinant plant made antibodies against fimbriae of enterotoxigenic Escherichia coli inhibit in vitro binding to villous enterocytes. ECMIS, Abstracts. Presented at the ECMIS 2011 : Escherichia coli and the Mucosal Immune System : interaction, modulation and vaccination.
Vancouver
1.
Virdi V, De Buck S, Coddens A, Goddeeris B, Cox E, De Greve H, et al. Recombinant plant made antibodies against fimbriae of enterotoxigenic Escherichia coli inhibit in vitro binding to villous enterocytes. ECMIS, Abstracts. 2011.
MLA
Virdi, Vikram, Sylvie De Buck, Annelies Coddens, et al. “Recombinant Plant Made Antibodies Against Fimbriae of Enterotoxigenic Escherichia Coli Inhibit in Vitro Binding to Villous Enterocytes.” ECMIS, Abstracts. 2011. Print.
@inproceedings{2008609,
  abstract     = {Plants can be used to produce a plethora of recombinant therapeutic proteins at fraction of a cost as compared to conventional production platforms. Plant seeds in particular are natural protein producing and storage organs, which enable production of abundant recombinant protein in stable confined environment. The seed based expression system is particularly interesting for oral passive immunisation against veterinarian diseases, such as enterotoxigenic Escherichia coli (ETEC) causing post weaning diarrhoea. We therefore investigated the production of anti-ETEC antibodies in seeds of the model plant Arabidopsis thaliana, to later transfer the technology to a grain crop that can be used in piglet starter feed and produced in sufficient quantities.},
  author       = {Virdi, Vikram and De Buck, Sylvie and Coddens, Annelies and Goddeeris, Bruno and Cox, Eric and De Greve, Henri and Depicker, Anna},
  booktitle    = {ECMIS, Abstracts},
  language     = {eng},
  location     = {Ghent, Belgium},
  title        = {Recombinant plant made antibodies against fimbriae of enterotoxigenic Escherichia coli inhibit in vitro binding to villous enterocytes},
  year         = {2011},
}