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Disposition of human drug preparations in the horse, II. orally administered fencamfamine

Frans Delbeke and Michel Debackere (1992) JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 10(9). p.651-656
abstract
A gas chromatographic method to measure urinary levels of the central nervous system stimulant fencamfamine and some of its metabolites is described. When 100 mg fencamfamine was given orally to four horses the parent drug could not be detected in the urine. After enzymatic hydrolysis of the urine the major human metabolite, N-desethylated fencamfamine, only accounted for 1% of the dose in 12 h. The major equine metabolites were conjugated parahydroxylated compounds representing 18% of the dose. With regard to horse doping control and analysis, the injudicious use of human doping routine methods for the detection of fencamfamine in equine urine could lead to false negative results.
Please use this url to cite or link to this publication:
author
organization
alternative title
Disposition of human drug preparations in the horse, 2. orally administered fencamfamine
year
type
journalArticle (original)
publication status
published
subject
keyword
:DOPING, FENCAMFAMINE, HORSE, METABOLISM, URINARY EXCRETION, CNS STIMULANT
journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
J. Pharm. Biomed. Anal.
volume
10
issue
9
pages
651 - 656
Web of Science type
Article
ISSN
0731-7085
DOI
10.1016/0731-7085(92)80093-3
language
English
UGent publication?
yes
classification
A1
id
200394
handle
http://hdl.handle.net/1854/LU-200394
date created
2004-01-14 13:42:00
date last changed
2018-04-12 08:07:46
@article{200394,
  abstract     = {A gas chromatographic method to measure urinary levels of the central nervous system stimulant fencamfamine and some of its metabolites is described. When 100 mg fencamfamine was given orally to four horses the parent drug could not be detected in the urine. After enzymatic hydrolysis of the urine the major human metabolite, N-desethylated fencamfamine, only accounted for 1\% of the dose in 12 h. The major equine metabolites were conjugated parahydroxylated compounds representing 18\% of the dose. With regard to horse doping control and analysis, the injudicious use of human doping routine methods for the detection of fencamfamine in equine urine could lead to false negative results.},
  author       = {Delbeke, Frans and Debackere, Michel},
  issn         = {0731-7085},
  journal      = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
  keyword      = {:DOPING,FENCAMFAMINE,HORSE,METABOLISM,URINARY EXCRETION,CNS STIMULANT},
  language     = {eng},
  number       = {9},
  pages        = {651--656},
  title        = {Disposition of human drug preparations in the horse, II. orally administered fencamfamine},
  url          = {http://dx.doi.org/10.1016/0731-7085(92)80093-3},
  volume       = {10},
  year         = {1992},
}

Chicago
Delbeke, Frans, and Michel Debackere. 1992. “Disposition of Human Drug Preparations in the Horse, II. Orally Administered Fencamfamine.” Journal of Pharmaceutical and Biomedical Analysis 10 (9): 651–656.
APA
Delbeke, F., & Debackere, M. (1992). Disposition of human drug preparations in the horse, II. orally administered fencamfamine. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 10(9), 651–656.
Vancouver
1.
Delbeke F, Debackere M. Disposition of human drug preparations in the horse, II. orally administered fencamfamine. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 1992;10(9):651–6.
MLA
Delbeke, Frans, and Michel Debackere. “Disposition of Human Drug Preparations in the Horse, II. Orally Administered Fencamfamine.” JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 10.9 (1992): 651–656. Print.