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Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses

Hamida Hammad UGent and Bart Lambrecht UGent (2011) ALLERGY. 66(5). p.579-587
abstract
Because they can recognize and sample inhaled allergens, dendritic cells (DC) have been shown to be responsible for the initiation and maintenance of adaptive Th2 responses in asthma. It is increasingly clear that DC functions are strongly influenced by a crosstalk with neighboring cells like epithelial cells. Whereas the epithelium was initially considered only as a barrier, it is now seen as a central player in controlling the function of lung DCs through release of innate cytokines-promoting Th2 responses. Clinically relevant allergens, as well as known environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells and DC. A better understanding of these interactions might lead to a better prevention and ultimately to new treatments for asthma.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
HELPER TYPE-2 RESPONSE, REGULATORY T-CELLS, THYMIC STROMAL LYMPHOPOIETIN, HOUSE-DUST MITE, epithelium, dendritic cells, asthma, allergens, BRONCHIAL LYMPH-NODE, IN-VIVO, ALLERGIC INFLAMMATION, INHALED ANTIGEN, RESPIRATORY-TRACT, TH2 RESPONSES
journal title
ALLERGY
Allergy
volume
66
issue
5
pages
579 - 587
Web of Science type
Review
Web of Science id
000289254800001
JCR category
ALLERGY
JCR impact factor
6.271 (2011)
JCR rank
2/23 (2011)
JCR quartile
1 (2011)
ISSN
0105-4538
DOI
10.1111/j.1398-9995.2010.02528.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2002814
handle
http://hdl.handle.net/1854/LU-2002814
date created
2012-01-25 11:57:56
date last changed
2015-06-17 09:55:27
@article{2002814,
  abstract     = {Because they can recognize and sample inhaled allergens, dendritic cells (DC) have been shown to be responsible for the initiation and maintenance of adaptive Th2 responses in asthma. It is increasingly clear that DC functions are strongly influenced by a crosstalk with neighboring cells like epithelial cells. Whereas the epithelium was initially considered only as a barrier, it is now seen as a central player in controlling the function of lung DCs through release of innate cytokines-promoting Th2 responses. Clinically relevant allergens, as well as known environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells and DC. A better understanding of these interactions might lead to a better prevention and ultimately to new treatments for asthma.},
  author       = {Hammad, Hamida and Lambrecht, Bart},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {HELPER TYPE-2 RESPONSE,REGULATORY T-CELLS,THYMIC STROMAL LYMPHOPOIETIN,HOUSE-DUST MITE,epithelium,dendritic cells,asthma,allergens,BRONCHIAL LYMPH-NODE,IN-VIVO,ALLERGIC INFLAMMATION,INHALED ANTIGEN,RESPIRATORY-TRACT,TH2 RESPONSES},
  language     = {eng},
  number       = {5},
  pages        = {579--587},
  title        = {Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2010.02528.x},
  volume       = {66},
  year         = {2011},
}

Chicago
Hammad, Hamida, and Bart Lambrecht. 2011. “Dendritic Cells and Airway Epithelial Cells at the Interface Between Innate and Adaptive Immune Responses.” Allergy 66 (5): 579–587.
APA
Hammad, H., & Lambrecht, B. (2011). Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses. ALLERGY, 66(5), 579–587.
Vancouver
1.
Hammad H, Lambrecht B. Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses. ALLERGY. 2011;66(5):579–87.
MLA
Hammad, Hamida, and Bart Lambrecht. “Dendritic Cells and Airway Epithelial Cells at the Interface Between Innate and Adaptive Immune Responses.” ALLERGY 66.5 (2011): 579–587. Print.