Advanced search

Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus

Author
Organization
Abstract
1 The receptors involved in mammalian tachykinin-induced contractions of longitudinal smooth muscle strips of the rat gastric fundus were characterized pharmacologically. 2 Substance P (SP), neurokinin A, neurokinin B and senktide contracted the strips in a concentration-dependent manner with a potency order of neurokinin A greater than or equal to senktide > neurokinin B > substance P. The contractions were not influenced by tetrodetoxin and atropine. 3 L 659877, a NK2B-receptor-preferring antagonist reduced neurokinin A- and neurokinin B-induced contractions (estimated pK(B) 6.9 and 6.3, respectively) but had less pronounced effects on SP-induced contractions and none on contractions induced by senktide. MEN 10376, an NK2A-receptor-preferring antagonist, reduced the neurokinin A-induced contractions (estimated pK(B) 5.2), while dactinomycin, reduced the neurokinin A-induced contractions only to a minor extent at 10(-4) M. 4 CP 96345, an NK1-receptor antagonist, reduced substance P- and neurokinin A-induced responses, but also reduced the contractions induced by KCl and methacholine. RP 67580, another non-peptide NK1-receptor antagonist had no effect on the substance P-, neurokinin A- and neurokinin B-induced contractions up to a concentration of 3 x 10(-6) M. 5 These results suggest that the mammalian tachykinins induce contractions of the longitudinal smooth muscle strip of the rat gastric fundus by direct action at muscular NK2B- and NK3-receptors.
Keywords
NEUROKININ-A, SUBSTANCE-P, AUTORADIOGRAPHIC LOCALIZATION, GASTROINTESTINAL-TRACT, SELECTIVE ANTAGONIST, ACTINOMYCIN-D, NK1 RECEPTOR, PEPTIDE, STOMACH, DACTINOMYCIN

Citation

Please use this url to cite or link to this publication:

Chicago
Smits, Geert JM, and Romain Lefebvre. 1994. “Tachykinin Receptors Involved in the Contractile Effect of the Natural Tachykinins in the Rat Gastric Fundus.” Journal of Autonomic Pharmacology 14 (6): 383–392.
APA
Smits, G. J., & Lefebvre, R. (1994). Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus. JOURNAL OF AUTONOMIC PHARMACOLOGY, 14(6), 383–392.
Vancouver
1.
Smits GJ, Lefebvre R. Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus. JOURNAL OF AUTONOMIC PHARMACOLOGY. 1994;14(6):383–92.
MLA
Smits, Geert JM, and Romain Lefebvre. “Tachykinin Receptors Involved in the Contractile Effect of the Natural Tachykinins in the Rat Gastric Fundus.” JOURNAL OF AUTONOMIC PHARMACOLOGY 14.6 (1994): 383–392. Print.
@article{200268,
  abstract     = {1 The receptors involved in mammalian tachykinin-induced contractions of longitudinal smooth muscle strips of the rat gastric fundus were characterized pharmacologically.
2 Substance P (SP), neurokinin A, neurokinin B and senktide contracted the strips in a concentration-dependent manner with a potency order of neurokinin A greater than or equal to senktide {\textrangle} neurokinin B {\textrangle} substance P. The contractions were not influenced by tetrodetoxin and atropine.
3 L 659877, a NK2B-receptor-preferring antagonist reduced neurokinin A- and neurokinin B-induced contractions (estimated pK(B) 6.9 and 6.3, respectively) but had less pronounced effects on SP-induced contractions and none on contractions induced by senktide. MEN 10376, an NK2A-receptor-preferring antagonist, reduced the neurokinin A-induced contractions (estimated pK(B) 5.2), while dactinomycin, reduced the neurokinin A-induced contractions only to a minor extent at 10(-4) M.
4 CP 96345, an NK1-receptor antagonist, reduced substance P- and neurokinin A-induced responses, but also reduced the contractions induced by KCl and methacholine. RP 67580, another non-peptide NK1-receptor antagonist had no effect on the substance P-, neurokinin A- and neurokinin B-induced contractions up to a concentration of 3 x 10(-6) M.
5 These results suggest that the mammalian tachykinins induce contractions of the longitudinal smooth muscle strip of the rat gastric fundus by direct action at muscular NK2B- and NK3-receptors.},
  author       = {Smits, Geert JM and Lefebvre, Romain},
  issn         = {0144-1795},
  journal      = {JOURNAL OF AUTONOMIC PHARMACOLOGY},
  keyword      = {NEUROKININ-A,SUBSTANCE-P,AUTORADIOGRAPHIC LOCALIZATION,GASTROINTESTINAL-TRACT,SELECTIVE ANTAGONIST,ACTINOMYCIN-D,NK1 RECEPTOR,PEPTIDE,STOMACH,DACTINOMYCIN},
  language     = {eng},
  number       = {6},
  pages        = {383--392},
  title        = {Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus},
  url          = {http://dx.doi.org/10.1111/j.1474-8673.1994.tb00619.x},
  volume       = {14},
  year         = {1994},
}

Altmetric
View in Altmetric