Ghent University Academic Bibliography

Advanced

Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus

Geert JM Smits and Romain Lefebvre UGent (1994) JOURNAL OF AUTONOMIC PHARMACOLOGY. 14(6). p.383-392
abstract
1 The receptors involved in mammalian tachykinin-induced contractions of longitudinal smooth muscle strips of the rat gastric fundus were characterized pharmacologically. 2 Substance P (SP), neurokinin A, neurokinin B and senktide contracted the strips in a concentration-dependent manner with a potency order of neurokinin A greater than or equal to senktide > neurokinin B > substance P. The contractions were not influenced by tetrodetoxin and atropine. 3 L 659877, a NK2B-receptor-preferring antagonist reduced neurokinin A- and neurokinin B-induced contractions (estimated pK(B) 6.9 and 6.3, respectively) but had less pronounced effects on SP-induced contractions and none on contractions induced by senktide. MEN 10376, an NK2A-receptor-preferring antagonist, reduced the neurokinin A-induced contractions (estimated pK(B) 5.2), while dactinomycin, reduced the neurokinin A-induced contractions only to a minor extent at 10(-4) M. 4 CP 96345, an NK1-receptor antagonist, reduced substance P- and neurokinin A-induced responses, but also reduced the contractions induced by KCl and methacholine. RP 67580, another non-peptide NK1-receptor antagonist had no effect on the substance P-, neurokinin A- and neurokinin B-induced contractions up to a concentration of 3 x 10(-6) M. 5 These results suggest that the mammalian tachykinins induce contractions of the longitudinal smooth muscle strip of the rat gastric fundus by direct action at muscular NK2B- and NK3-receptors.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
NEUROKININ-A, SUBSTANCE-P, AUTORADIOGRAPHIC LOCALIZATION, GASTROINTESTINAL-TRACT, SELECTIVE ANTAGONIST, ACTINOMYCIN-D, NK1 RECEPTOR, PEPTIDE, STOMACH, DACTINOMYCIN
journal title
JOURNAL OF AUTONOMIC PHARMACOLOGY
J. Auton. Pharmacol.
volume
14
issue
6
pages
383 - 392
Web of Science type
Article
ISSN
0144-1795
DOI
10.1111/j.1474-8673.1994.tb00619.x
language
English
UGent publication?
yes
classification
A1
id
200268
handle
http://hdl.handle.net/1854/LU-200268
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:38:50
@article{200268,
  abstract     = {1 The receptors involved in mammalian tachykinin-induced contractions of longitudinal smooth muscle strips of the rat gastric fundus were characterized pharmacologically.
2 Substance P (SP), neurokinin A, neurokinin B and senktide contracted the strips in a concentration-dependent manner with a potency order of neurokinin A greater than or equal to senktide {\textrangle} neurokinin B {\textrangle} substance P. The contractions were not influenced by tetrodetoxin and atropine.
3 L 659877, a NK2B-receptor-preferring antagonist reduced neurokinin A- and neurokinin B-induced contractions (estimated pK(B) 6.9 and 6.3, respectively) but had less pronounced effects on SP-induced contractions and none on contractions induced by senktide. MEN 10376, an NK2A-receptor-preferring antagonist, reduced the neurokinin A-induced contractions (estimated pK(B) 5.2), while dactinomycin, reduced the neurokinin A-induced contractions only to a minor extent at 10(-4) M.
4 CP 96345, an NK1-receptor antagonist, reduced substance P- and neurokinin A-induced responses, but also reduced the contractions induced by KCl and methacholine. RP 67580, another non-peptide NK1-receptor antagonist had no effect on the substance P-, neurokinin A- and neurokinin B-induced contractions up to a concentration of 3 x 10(-6) M.
5 These results suggest that the mammalian tachykinins induce contractions of the longitudinal smooth muscle strip of the rat gastric fundus by direct action at muscular NK2B- and NK3-receptors.},
  author       = {Smits, Geert JM and Lefebvre, Romain},
  issn         = {0144-1795},
  journal      = {JOURNAL OF AUTONOMIC PHARMACOLOGY},
  keyword      = {NEUROKININ-A,SUBSTANCE-P,AUTORADIOGRAPHIC LOCALIZATION,GASTROINTESTINAL-TRACT,SELECTIVE ANTAGONIST,ACTINOMYCIN-D,NK1 RECEPTOR,PEPTIDE,STOMACH,DACTINOMYCIN},
  language     = {eng},
  number       = {6},
  pages        = {383--392},
  title        = {Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus},
  url          = {http://dx.doi.org/10.1111/j.1474-8673.1994.tb00619.x},
  volume       = {14},
  year         = {1994},
}

Chicago
Smits, Geert JM, and Romain Lefebvre. 1994. “Tachykinin Receptors Involved in the Contractile Effect of the Natural Tachykinins in the Rat Gastric Fundus.” Journal of Autonomic Pharmacology 14 (6): 383–392.
APA
Smits, G. J., & Lefebvre, R. (1994). Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus. JOURNAL OF AUTONOMIC PHARMACOLOGY, 14(6), 383–392.
Vancouver
1.
Smits GJ, Lefebvre R. Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus. JOURNAL OF AUTONOMIC PHARMACOLOGY. 1994;14(6):383–92.
MLA
Smits, Geert JM, and Romain Lefebvre. “Tachykinin Receptors Involved in the Contractile Effect of the Natural Tachykinins in the Rat Gastric Fundus.” JOURNAL OF AUTONOMIC PHARMACOLOGY 14.6 (1994): 383–392. Print.