Advanced search
1 file | 486.48 KB

MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

(2011) ALLERGY. 66(5). p.596-604
Author
Organization
Abstract
The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of 'classical' and 'novel' phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues
Keywords
mechanisms of the development of allergy, IgE, prevention, mechanisms, epigenetics, early diagnosis, allergy, framework programme 7, proteomics, systems medicine, transcriptomics, BIRTH COHORT, ASTHMA, ENVIRONMENT, CHILDHOOD, GENES, VARIANTS, DISEASES, CHILDREN, RISK, LIFE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 486.48 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Bousquet, J, J Anto, C Auffray, M Akdis, A Cambon-Thomsen, T Keil, T Haahtela, et al. 2011. “MeDALL (Mechanisms of the Development of ALLergy): An Integrated Approach from Phenotypes to Systems Medicine.” Allergy 66 (5): 596–604.
APA
Bousquet, J, Anto, J., Auffray, C., Akdis, M., Cambon-Thomsen, A., Keil, T., Haahtela, T., et al. (2011). MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. ALLERGY, 66(5), 596–604.
Vancouver
1.
Bousquet J, Anto J, Auffray C, Akdis M, Cambon-Thomsen A, Keil T, et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. ALLERGY. 2011;66(5):596–604.
MLA
Bousquet, J, J Anto, C Auffray, et al. “MeDALL (Mechanisms of the Development of ALLergy): An Integrated Approach from Phenotypes to Systems Medicine.” ALLERGY 66.5 (2011): 596–604. Print.
@article{2002666,
  abstract     = {The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of 'classical' and 'novel' phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues},
  author       = {Bousquet, J and Anto, J and Auffray, C and Akdis, M and Cambon-Thomsen, A and Keil, T and Haahtela, T and Lambrecht, Bart and Postma, DS and Sunyer, J and Valenta, R and Akdis, CA and Annesi-Maesano, I and Arno, A and Bachert, Claus and Ballester, F and Basagana, X and Baumgartner, U and Bindslev-Jensen, C and Brunekreef, B and Carlsen, KH and Chatzi, L and Crameri, R and Eveno, E and Forastiere, F and Garcia-Aymerich, J and Guerra, S and Hammad, Hamida and Heinrich, J and Hirsch, D and Jacquemin, B and Kauffmann, F and Kerkhof, M and Kogevinas, M and Koppelman, GH and Kowalski, ML and Lau, S and Lodrup-Carlsen, KC and Lopez-Botet, M and Lotvall, J and Lupinek, C and Maier, D and Makela, MJ and Martinez, FD and Mestres, J and Momas, I and Nawijn, MC and Neubauer, A and Oddie, S and Palkonen, S and Pin, I and Pison, C and Ranc{\'e}, F and Reitamo, S and Rial-Sebbag, E and Salapatas, M and Siroux, V and Smagghe, D and Torrent, M and Toskala, E and Van Cauwenberge, Paul and van Oosterhout, AJM and Varraso, R and von Hertzen, L and Wickman, M and Wijmenga, C and Worm, M and Wright, J and Zuberbier, T},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {mechanisms of the development of allergy,IgE,prevention,mechanisms,epigenetics,early diagnosis,allergy,framework programme 7,proteomics,systems medicine,transcriptomics,BIRTH COHORT,ASTHMA,ENVIRONMENT,CHILDHOOD,GENES,VARIANTS,DISEASES,CHILDREN,RISK,LIFE},
  language     = {eng},
  number       = {5},
  pages        = {596--604},
  title        = {MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2010.02534.x},
  volume       = {66},
  year         = {2011},
}

Altmetric
View in Altmetric
Web of Science
Times cited: