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Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves

Bart Pardon UGent, Boudewijn Catry, Jeroen Dewulf UGent, Davy Persoons UGent, Miel Hostens UGent, Koen De Bleecker and Piet Deprez UGent (2012) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 67(4). p.1027-1038
abstract
To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present. Drug consumption data were prospectively collected on 15 white veal production cohorts (n5853 calves) in Belgium (200709). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression. The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8). Of the oral group antimicrobial treatments, 12 and 88 were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7), amoxicillin (18.5), tylosin (17.2) and colistin (15.2). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7 of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3 of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P0.05); an integration is defined as a company that combines all steps of the production chain by having its own feed plant and slaughterhouse and by placing its calves in veal herds owned by producers that fatten these calves for this integration on contract. Producers used higher dosages than prescribed by the veterinarian in cohorts with a single caretaker (P0.01). The present study provided detailed information on the intensive antimicrobial use in the white veal industry. Reduction can only be achieved by reducing the number of oral group treatments.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
group treatment, defined daily doses, antimicrobials, anti-inflammatory drugs, dosing, BOVINE RESPIRATORY-DISEASE, RESISTANT STAPHYLOCOCCUS-AUREUS, DIFFERENT EUROPEAN COUNTRIES, FECAL ESCHERICHIA-COLI, BACTERIAL PATHOGENS, INDICATOR BACTERIA, FEEDLOT CATTLE, DAIRY CALVES, EPIDEMIOLOGY, PREVALENCE
journal title
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
J. Antimicrob. Chemother.
volume
67
issue
4
pages
1027 - 1038
Web of Science type
Article
Web of Science id
000301684900035
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
5.338 (2012)
JCR rank
18/259 (2012)
JCR quartile
1 (2012)
ISSN
0305-7453
DOI
10.1093/jac/dkr570
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1999928
handle
http://hdl.handle.net/1854/LU-1999928
date created
2012-01-23 13:21:13
date last changed
2012-09-11 16:31:28
@article{1999928,
  abstract     = {To document and quantify drug use in white veal calves, an intensive livestock production system where multidrug resistance is abundantly present. 
Drug consumption data were prospectively collected on 15 white veal production cohorts (n5853 calves) in Belgium (200709). Treatment incidences (TIs) based on animal defined daily dose (ADD), prescribed daily dose (PDD) and used daily dose (UDD) were calculated. Risk factors were identified by linear regression. 
The average TIADD of antimicrobial treatments was 416.8 ADD per 1000 animals at risk. Predominantly, oral group antimicrobial treatments were used (95.8). Of the oral group antimicrobial treatments, 12 and 88 were used for prophylactic or metaphylactic indications, respectively. The main indication for group and individual drug use was respiratory disease. The most frequently used antimicrobials (group treatments) were oxytetracycline (23.7), amoxicillin (18.5), tylosin (17.2) and colistin (15.2). Deviations from the leaflet dosage recommendations were frequently encountered, with 43.7 of the group treatments underdosed (often oxytetracycline and tylosin to treat dysbacteriosis). In 33.3 of the oral antimicrobial group treatments a combination of two antimicrobial preparations was used. Smaller integrations used more antimicrobials in group treatments than larger ones (P0.05); an integration is defined as a company that combines all steps of the production chain by having its own feed plant and slaughterhouse and by placing its calves in veal herds owned by producers that fatten these calves for this integration on contract. Producers used higher dosages than prescribed by the veterinarian in cohorts with a single caretaker (P0.01). 
The present study provided detailed information on the intensive antimicrobial use in the white veal industry. Reduction can only be achieved by reducing the number of oral group treatments.},
  author       = {Pardon, Bart and Catry, Boudewijn and Dewulf, Jeroen and Persoons, Davy and Hostens, Miel and De Bleecker, Koen and Deprez, Piet},
  issn         = {0305-7453},
  journal      = {JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY},
  keyword      = {group treatment,defined daily doses,antimicrobials,anti-inflammatory drugs,dosing,BOVINE RESPIRATORY-DISEASE,RESISTANT STAPHYLOCOCCUS-AUREUS,DIFFERENT EUROPEAN COUNTRIES,FECAL ESCHERICHIA-COLI,BACTERIAL PATHOGENS,INDICATOR BACTERIA,FEEDLOT CATTLE,DAIRY CALVES,EPIDEMIOLOGY,PREVALENCE},
  language     = {eng},
  number       = {4},
  pages        = {1027--1038},
  title        = {Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves},
  url          = {http://dx.doi.org/10.1093/jac/dkr570},
  volume       = {67},
  year         = {2012},
}

Chicago
Pardon, Bart, Boudewijn Catry, Jeroen Dewulf, Davy Persoons, Miel Hostens, Koen De Bleecker, and Piet Deprez. 2012. “Prospective Study on Quantitative and Qualitative Antimicrobial and Anti-inflammatory Drug Use in White Veal Calves.” Journal of Antimicrobial Chemotherapy 67 (4): 1027–1038.
APA
Pardon, B., Catry, B., Dewulf, J., Persoons, D., Hostens, M., De Bleecker, K., & Deprez, P. (2012). Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 67(4), 1027–1038.
Vancouver
1.
Pardon B, Catry B, Dewulf J, Persoons D, Hostens M, De Bleecker K, et al. Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2012;67(4):1027–38.
MLA
Pardon, Bart, Boudewijn Catry, Jeroen Dewulf, et al. “Prospective Study on Quantitative and Qualitative Antimicrobial and Anti-inflammatory Drug Use in White Veal Calves.” JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 67.4 (2012): 1027–1038. Print.