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Metabolic tumour volume: prognostic value in locally advanced squamous cell carcinoma of the head and neck

Philippe Deron UGent, Koen Mertens UGent, Ingeborg Goethals UGent, Sylvie Rottey UGent, Fréderic Duprez UGent, Wilfried De Neve UGent, Hubert Vermeersch UGent and Christophe Van De Wiele UGent (2011) NUKLEARMEDIZIN-NUCLEAR MEDICINE. 50(4). p.141-146
abstract
Purpose: Evaluate the predictive and prognostic value of semi-quantitative FDG-PET variables derived from pretreatment FDG-PET images in patients suffering from locally advanced squamous cell carcinoma of the head and neck (SCCHN), treated by means of concomitant radiochemotherapy. Patients, methods: 40 patients with newly diagnosed SCCHN that were treated with concomitant radiochemotherapy underwent FDG-PET/CT for treatment planning; 18 patients had neck dissection prior to their baseline scan and to receiving radiochemotherapy. FDG-PET images were used to calculate metabolic tumour volumes using region growing and a threshold of 50% (MTV(50)) of primary lesions and involved lymph nodes as well as the mean and maximum standard uptake value (SUVmean and SUVmax) of the primary tumours. Results: Neither SUVmean nor SUVmax values of the primary tumour were significantly different between responders and non-responders whereas MTV50 values of the primary tumour proved significantly higher in non-responders. SUVmean, SUVmax and MTV(50) of the primary tumour were not predictive for overall or disease free survival. Contrariwise, dichotomized summed MTV(50) values (cut-off >= 31 cm(3)) of the primary tumour and involved lymph nodes in patients that didn't have neck dissection prior to radiochemotherapy were predictive for disease free and overall survival in both univariate and multivariate analysis (p <= 0.05). Conclusion: Summed MTV(50) values of both the primary tumour and involved lymph nodes provided independent prognostic information on disease free and overall survival.
Please use this url to cite or link to this publication:
author
organization
alternative title
Metabolisches Tumorvolumen : prognostische Bedeutung bei lokal fortgeschrittenen Plattenepithelkarzinomen im Kopf-Hals-Bereich
year
type
journalArticle (original)
publication status
published
subject
keyword
CANCER, F-18-FDG PET, PREDICTION, METASTASIS, SURVIVAL, RADIOCHEMOTHERAPY, prognosis, STANDARDIZED UPTAKE VALUE, FDG-PET, DEFINITIVE RADIOTHERAPY, RECURRENT HEAD, locally advanced SCCHN
journal title
NUKLEARMEDIZIN-NUCLEAR MEDICINE
Nuklearmedizin
volume
50
issue
4
pages
141 - 146
Web of Science type
Article
Web of Science id
000294693900002
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.28 (2011)
JCR rank
80/116 (2011)
JCR quartile
3 (2011)
ISSN
0029-5566
DOI
10.3413/Nukmed-0367-10-11
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1998735
handle
http://hdl.handle.net/1854/LU-1998735
date created
2012-01-20 15:15:24
date last changed
2012-03-21 13:25:02
@article{1998735,
  abstract     = {Purpose: Evaluate the predictive and prognostic value of semi-quantitative FDG-PET variables derived from pretreatment FDG-PET images in patients suffering from locally advanced squamous cell carcinoma of the head and neck (SCCHN), treated by means of concomitant radiochemotherapy. Patients, methods: 40 patients with newly diagnosed SCCHN that were treated with concomitant radiochemotherapy underwent FDG-PET/CT for treatment planning; 18 patients had neck dissection prior to their baseline scan and to receiving radiochemotherapy. FDG-PET images were used to calculate metabolic tumour volumes using region growing and a threshold of 50\% (MTV(50)) of primary lesions and involved lymph nodes as well as the mean and maximum standard uptake value (SUVmean and SUVmax) of the primary tumours. Results: Neither SUVmean nor SUVmax values of the primary tumour were significantly different between responders and non-responders whereas MTV50 values of the primary tumour proved significantly higher in non-responders. SUVmean, SUVmax and MTV(50) of the primary tumour were not predictive for overall or disease free survival. Contrariwise, dichotomized summed MTV(50) values (cut-off {\textrangle}= 31 cm(3)) of the primary tumour and involved lymph nodes in patients that didn't have neck dissection prior to radiochemotherapy were predictive for disease free and overall survival in both univariate and multivariate analysis (p {\textlangle}= 0.05). Conclusion: Summed MTV(50) values of both the primary tumour and involved lymph nodes provided independent prognostic information on disease free and overall survival.},
  author       = {Deron, Philippe and Mertens, Koen and Goethals, Ingeborg and Rottey, Sylvie and Duprez, Fr{\'e}deric and De Neve, Wilfried and Vermeersch, Hubert and Van De Wiele, Christophe},
  issn         = {0029-5566},
  journal      = {NUKLEARMEDIZIN-NUCLEAR MEDICINE},
  keyword      = {CANCER,F-18-FDG PET,PREDICTION,METASTASIS,SURVIVAL,RADIOCHEMOTHERAPY,prognosis,STANDARDIZED UPTAKE VALUE,FDG-PET,DEFINITIVE RADIOTHERAPY,RECURRENT HEAD,locally advanced SCCHN},
  language     = {eng},
  number       = {4},
  pages        = {141--146},
  title        = {Metabolic tumour volume: prognostic value in locally advanced squamous cell carcinoma of the head and neck},
  url          = {http://dx.doi.org/10.3413/Nukmed-0367-10-11},
  volume       = {50},
  year         = {2011},
}

Chicago
DERON, PHILIPPE, Koen Mertens, Ingeborg Goethals, Sylvie Rottey, Fréderic Duprez, Wilfried De Neve, Hubert Vermeersch, and Christophe Van De Wiele. 2011. “Metabolic Tumour Volume: Prognostic Value in Locally Advanced Squamous Cell Carcinoma of the Head and Neck.” Nuklearmedizin-nuclear Medicine 50 (4): 141–146.
APA
DERON, P., Mertens, K., Goethals, I., Rottey, S., Duprez, F., De Neve, W., Vermeersch, H., et al. (2011). Metabolic tumour volume: prognostic value in locally advanced squamous cell carcinoma of the head and neck. NUKLEARMEDIZIN-NUCLEAR MEDICINE, 50(4), 141–146.
Vancouver
1.
DERON P, Mertens K, Goethals I, Rottey S, Duprez F, De Neve W, et al. Metabolic tumour volume: prognostic value in locally advanced squamous cell carcinoma of the head and neck. NUKLEARMEDIZIN-NUCLEAR MEDICINE. 2011;50(4):141–6.
MLA
DERON, PHILIPPE, Koen Mertens, Ingeborg Goethals, et al. “Metabolic Tumour Volume: Prognostic Value in Locally Advanced Squamous Cell Carcinoma of the Head and Neck.” NUKLEARMEDIZIN-NUCLEAR MEDICINE 50.4 (2011): 141–146. Print.