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High dose chemotherapy and stem cell rescue for metastatic germ cell tumours: long term results from a single institution

Vibeke Kruse UGent, Lucien Noens UGent, Nicolaas Lumen UGent, Piet Hoebeke UGent, Simon Van Belle UGent and Sylvie Rottey UGent (2011) ACTA CLINICA BELGICA. 66(4). p.254-259
abstract
Purpose: To evaluate the long term results and the characteristics of patients treated with high dose chemotherapy (HDCT) for an advanced germ cell tumour at Ghent University Hospital from 1996 to 2010. Materials and Methods: A retrospective analysis of patients treated with HDCT for germ cell tumours was performed. Data about stage at diagnosis, different prognostic scoring systems, timing of HDCT, response to HDCT and relapse-free period were collected. The following endpoints were evaluated: complete or incomplete response to HDCT, relapse free survival and overall survival time. Results: Of the 148 patients treated with chemotherapy for an advanced germ cell tumour from 1996 to 2010, 10 (6,8%) needed salvage treatment by means of HDCT. Six patients achieved a complete response to one cycle of HDCT and 2 additional patients achieved a complete response to a second cycle of HDCT. A retrospective analysis showed 8 long term survivors with a maximum follow-up time of 152 months. Two patients were recently transplanted and are not evaluable for survival yet. Conclusions: Our study suggests that long term survival can be obtained by means of HDCT for metastatic germ cell tumours, even in patients with bad prognostic features at diagnosis. The question of whether to use 1 or 2 cycles of HDCT still remains unanswered.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
germ cell tumours, high dose chemotherapy, advanced disease, salvage therapy, SALVAGE TREATMENT, PROGNOSTIC-FACTORS, 1ST-LINE CHEMOTHERAPY, TESTICULAR CANCER, RANDOMIZED-TRIAL, CISPLATIN, ETOPOSIDE, CLASSIFICATION, CARBOPLATIN, IFOSFAMIDE
journal title
ACTA CLINICA BELGICA
Acta Clin. Belg.
volume
66
issue
4
pages
254 - 259
Web of Science type
Article
Web of Science id
000295022700002
JCR category
MEDICINE, GENERAL & INTERNAL
JCR impact factor
0.592 (2011)
JCR rank
105/153 (2011)
JCR quartile
3 (2011)
ISSN
0001-5512
DOI
10.2143/ACB.66.4.2062565
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1998692
handle
http://hdl.handle.net/1854/LU-1998692
date created
2012-01-20 15:15:24
date last changed
2012-03-08 09:45:33
@article{1998692,
  abstract     = {Purpose: To evaluate the long term results and the characteristics of patients treated with high dose chemotherapy (HDCT) for an advanced germ cell tumour at Ghent University Hospital from 1996 to 2010. 
Materials and Methods: A retrospective analysis of patients treated with HDCT for germ cell tumours was performed. Data about stage at diagnosis, different prognostic scoring systems, timing of HDCT, response to HDCT and relapse-free period were collected. The following endpoints were evaluated: complete or incomplete response to HDCT, relapse free survival and overall survival time. 
Results: Of the 148 patients treated with chemotherapy for an advanced germ cell tumour from 1996 to 2010, 10 (6,8\%) needed salvage treatment by means of HDCT. Six patients achieved a complete response to one cycle of HDCT and 2 additional patients achieved a complete response to a second cycle of HDCT. A retrospective analysis showed 8 long term survivors with a maximum follow-up time of 152 months. Two patients were recently transplanted and are not evaluable for survival yet. 
Conclusions: Our study suggests that long term survival can be obtained by means of HDCT for metastatic germ cell tumours, even in patients with bad prognostic features at diagnosis. The question of whether to use 1 or 2 cycles of HDCT still remains unanswered.},
  author       = {Kruse, Vibeke and Noens, Lucien and Lumen, Nicolaas and Hoebeke, Piet and Van Belle, Simon and Rottey, Sylvie},
  issn         = {0001-5512},
  journal      = {ACTA CLINICA BELGICA},
  keyword      = {germ cell tumours,high dose chemotherapy,advanced disease,salvage therapy,SALVAGE TREATMENT,PROGNOSTIC-FACTORS,1ST-LINE CHEMOTHERAPY,TESTICULAR CANCER,RANDOMIZED-TRIAL,CISPLATIN,ETOPOSIDE,CLASSIFICATION,CARBOPLATIN,IFOSFAMIDE},
  language     = {eng},
  number       = {4},
  pages        = {254--259},
  title        = {High dose chemotherapy and stem cell rescue for metastatic germ cell tumours: long term results from a single institution},
  url          = {http://dx.doi.org/10.2143/ACB.66.4.2062565},
  volume       = {66},
  year         = {2011},
}

Chicago
Kruse, Vibeke, Lucien Noens, Nicolaas Lumen, Piet Hoebeke, Simon Van Belle, and Sylvie Rottey. 2011. “High Dose Chemotherapy and Stem Cell Rescue for Metastatic Germ Cell Tumours: Long Term Results from a Single Institution.” Acta Clinica Belgica 66 (4): 254–259.
APA
Kruse, V., Noens, L., Lumen, N., Hoebeke, P., Van Belle, S., & Rottey, S. (2011). High dose chemotherapy and stem cell rescue for metastatic germ cell tumours: long term results from a single institution. ACTA CLINICA BELGICA, 66(4), 254–259.
Vancouver
1.
Kruse V, Noens L, Lumen N, Hoebeke P, Van Belle S, Rottey S. High dose chemotherapy and stem cell rescue for metastatic germ cell tumours: long term results from a single institution. ACTA CLINICA BELGICA. 2011;66(4):254–9.
MLA
Kruse, Vibeke, Lucien Noens, Nicolaas Lumen, et al. “High Dose Chemotherapy and Stem Cell Rescue for Metastatic Germ Cell Tumours: Long Term Results from a Single Institution.” ACTA CLINICA BELGICA 66.4 (2011): 254–259. Print.