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The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients

Steven Van Laecke UGent, Céline Maréchal, Francis Verbeke UGent, Patrick Peeters UGent, Wim Van Biesen UGent, Olivier Devuyst, Michel Jadoul and Raymond Vanholder UGent (2011) NEPHROLOGY DIALYSIS TRANSPLANTATION. 26(7). p.2362-2369
abstract
Background. Arterial stiffness is a strong predictor of outcome. Hypomagnesaemia, by its association with arterial hypertension, endothelial dysfunction, dyslipidaemia and inflammation, might affect vascular stiffness. As hypomagnesaemia is common in renal transplant recipients (RTR), we examined its potential association with arterial stiffness. Methods. Cross-sectional analysis. Evaluation of vascular stiffness in 512 RTR from two university centres at a median of 72 months post-transplantation. Determination of carotid-femoral pulse wave velocity (PWV) (SphygmoCor). A multiple linear regression analysis was used to investigate the independent relationship between magnesium serum level and PWV with the following covariates: age, diabetes, smoking status, body mass index, blood pressure, heart rate (HR), C-reactive protein (CRP), high-density lipoprotein cholesterol, parathyroid hormone and use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, diuretics, calcium channel blockers, statins and calcineurin inhibitors next to their drug levels. Results. Lower serum magnesium was independently associated with PWV (P = 0.018) in addition to age, CRP, HR, diabetes and mean arterial pressure (model R(2) = 0.45; P < 0.001). The relationship between magnesium and PWV was attenuated (P = 0.054) after adjustment for the use of sirolimus, which was associated with higher magnesium levels (P < 0.001) and lower PWV (P = 0.013). In patients > 55 years (median age), however (low), magnesium remained an independent predictor of PWV (P = 0.024) after accounting for the same covariates. Conclusions. Serum magnesium is an independent predictor of arterial stiffness in RTR, especially in patients > 55 years.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
AORTIC STIFFNESS, ENDOTHELIAL DYSFUNCTION, ARTERIAL STIFFNESS, C-REACTIVE PROTEIN, PULSE-WAVE VELOCITY, sirolimus, INTRACELLULAR FREE MAGNESIUM, pulse wave velocity, hypomagnesaemia, INDEPENDENT PREDICTOR, HYPERTENSIVE PATIENTS, HEMODIALYSIS-PATIENTS, MAGNETIC-RESONANCE
journal title
NEPHROLOGY DIALYSIS TRANSPLANTATION
Nephrol. Dial. Transplant.
volume
26
issue
7
pages
2362 - 2369
Web of Science type
Article
Web of Science id
000292329500046
JCR category
UROLOGY & NEPHROLOGY
JCR impact factor
3.396 (2011)
JCR rank
15/72 (2011)
JCR quartile
1 (2011)
ISSN
0931-0509
DOI
10.1093/ndt/gfq728
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1998084
handle
http://hdl.handle.net/1854/LU-1998084
date created
2012-01-20 11:05:35
date last changed
2014-07-01 14:48:51
@article{1998084,
  abstract     = {Background. Arterial stiffness is a strong predictor of outcome. Hypomagnesaemia, by its association with arterial hypertension, endothelial dysfunction, dyslipidaemia and inflammation, might affect vascular stiffness. As hypomagnesaemia is common in renal transplant recipients (RTR), we examined its potential association with arterial stiffness. 
Methods. Cross-sectional analysis. Evaluation of vascular stiffness in 512 RTR from two university centres at a median of 72 months post-transplantation. Determination of carotid-femoral pulse wave velocity (PWV) (SphygmoCor). A multiple linear regression analysis was used to investigate the independent relationship between magnesium serum level and PWV with the following covariates: age, diabetes, smoking status, body mass index, blood pressure, heart rate (HR), C-reactive protein (CRP), high-density lipoprotein cholesterol, parathyroid hormone and use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, diuretics, calcium channel blockers, statins and calcineurin inhibitors next to their drug levels. 
Results. Lower serum magnesium was independently associated with PWV (P = 0.018) in addition to age, CRP, HR, diabetes and mean arterial pressure (model R(2) = 0.45; P {\textlangle} 0.001). The relationship between magnesium and PWV was attenuated (P = 0.054) after adjustment for the use of sirolimus, which was associated with higher magnesium levels (P {\textlangle} 0.001) and lower PWV (P = 0.013). In patients {\textrangle} 55 years (median age), however (low), magnesium remained an independent predictor of PWV (P = 0.024) after accounting for the same covariates. 
Conclusions. Serum magnesium is an independent predictor of arterial stiffness in RTR, especially in patients {\textrangle} 55 years.},
  author       = {Van Laecke, Steven and Mar{\'e}chal, C{\'e}line and Verbeke, Francis and Peeters, Patrick and Van Biesen, Wim and Devuyst, Olivier and Jadoul, Michel and Vanholder, Raymond},
  issn         = {0931-0509},
  journal      = {NEPHROLOGY DIALYSIS TRANSPLANTATION},
  keyword      = {AORTIC STIFFNESS,ENDOTHELIAL DYSFUNCTION,ARTERIAL STIFFNESS,C-REACTIVE PROTEIN,PULSE-WAVE VELOCITY,sirolimus,INTRACELLULAR FREE MAGNESIUM,pulse wave velocity,hypomagnesaemia,INDEPENDENT PREDICTOR,HYPERTENSIVE PATIENTS,HEMODIALYSIS-PATIENTS,MAGNETIC-RESONANCE},
  language     = {eng},
  number       = {7},
  pages        = {2362--2369},
  title        = {The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients},
  url          = {http://dx.doi.org/10.1093/ndt/gfq728},
  volume       = {26},
  year         = {2011},
}

Chicago
VAN LAECKE, STEVEN b, Céline Maréchal, FRANCIS VERBEKE, Patrick Peeters, Wim Van Biesen, Olivier Devuyst, Michel Jadoul, and Raymond Vanholder. 2011. “The Relation Between Hypomagnesaemia and Vascular Stiffness in Renal Transplant Recipients.” Nephrology Dialysis Transplantation 26 (7): 2362–2369.
APA
VAN LAECKE, S. b, Maréchal, C., VERBEKE, F., Peeters, P., Van Biesen, W., Devuyst, O., Jadoul, M., et al. (2011). The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients. NEPHROLOGY DIALYSIS TRANSPLANTATION, 26(7), 2362–2369.
Vancouver
1.
VAN LAECKE S b, Maréchal C, VERBEKE F, Peeters P, Van Biesen W, Devuyst O, et al. The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2011;26(7):2362–9.
MLA
VAN LAECKE, STEVEN b, Céline Maréchal, FRANCIS VERBEKE, et al. “The Relation Between Hypomagnesaemia and Vascular Stiffness in Renal Transplant Recipients.” NEPHROLOGY DIALYSIS TRANSPLANTATION 26.7 (2011): 2362–2369. Print.