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IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use ?

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Abstract
Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.
Keywords
LIPOPROTEIN CHOLESTEROL LEVELS, GENETIC-VARIATION, SPONTANEOUS CLEARANCE, VIROLOGICAL RESPONSE, INTERFERON-LAMBDA, RIBAVIRIN THERAPY, INTERLEUKIN 28B, VIRAL RESPONSE, CORE REGION, GENOTYPE 2

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Citation

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Chicago
Orlent, Hans, Hendrik Reynaert, Stefan Bourgeois, Vinciane Dideberg, Michael Adler, Isabelle Colle, Stephane De Maeght, et al. 2011. “IL28B Polymorphism and the Control of Hepatitis C Virus Infection: Ready for Clinical Use ?” Acta Gastro-enterologica Belgica 74 (2): 317–322.
APA
Orlent, H., Reynaert, H., Bourgeois, S., Dideberg, V., Adler, M., Colle, I., De Maeght, S., et al. (2011). IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use ? ACTA GASTRO-ENTEROLOGICA BELGICA, 74(2), 317–322.
Vancouver
1.
Orlent H, Reynaert H, Bourgeois S, Dideberg V, Adler M, Colle I, et al. IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use ? ACTA GASTRO-ENTEROLOGICA BELGICA. 2011;74(2):317–22.
MLA
Orlent, Hans, Hendrik Reynaert, Stefan Bourgeois, et al. “IL28B Polymorphism and the Control of Hepatitis C Virus Infection: Ready for Clinical Use ?” ACTA GASTRO-ENTEROLOGICA BELGICA 74.2 (2011): 317–322. Print.
@article{1997728,
  abstract     = {Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.},
  author       = {Orlent, Hans and Reynaert, Hendrik and Bourgeois, Stefan and Dideberg, Vinciane and Adler, Michael and Colle, Isabelle and De Maeght, Stephane and Laleman, Wim and Michielsen, Peter and Moreno, Christophe and Mulkay, Jen-Pierre and Starkel, Peter and Delwaide, Jean},
  issn         = {0001-5644},
  journal      = {ACTA GASTRO-ENTEROLOGICA BELGICA},
  keyword      = {LIPOPROTEIN CHOLESTEROL LEVELS,GENETIC-VARIATION,SPONTANEOUS CLEARANCE,VIROLOGICAL RESPONSE,INTERFERON-LAMBDA,RIBAVIRIN THERAPY,INTERLEUKIN 28B,VIRAL RESPONSE,CORE REGION,GENOTYPE 2},
  language     = {eng},
  number       = {2},
  pages        = {317--322},
  title        = {IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use ?},
  volume       = {74},
  year         = {2011},
}

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