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Anti-inflammatory actions of phosphatidylinositol

Jolanda M van Dieren, Ytje Simons-Oosterhuis, HC (Rolien) Raatgeep, Dicky J Lindenbergh-Kortleve, Margaretha EH Lambers, C Janneke van der Woude, Ernst J Kuipers, Gerry T Snoek, Ron Potman, Hamida Hammad (UGent) , et al.
(2011) EUROPEAN JOURNAL OF IMMUNOLOGY. 41(4). p.1047-1057
Author
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Abstract
Chronic inflammatory T-cell-mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T-cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less-toxic alternatives. We aimed to investigate the immunoregulatory capacities of the naturally occurring phospholipid phosphatidylinositol (PI). Systemic PI treatment dramatically reduced disease severity and intestinal inflammation in murine 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis. Moreover, PI treatment inhibited the inflammatory T-cell response in these mice, as T cells derived from colon-draining LN of PI-treated mice secreted less IL-17 and IFN-gamma upon polyclonal restimulation when compared to those of saline-treated mice. Further characterization of the suppressive capacity of PI revealed that the phospholipid suppressed Th cell differentiation in vitro irrespective of their cytokine profile by inhibiting proliferation and IL-2 release. In particular, PI diminished IL-2 mRNA expression and inhibited ERK1-, ERK-2-, p38- and JNK-phosphorylation. Crucially, PI did not ablate Treg differentiation or the antigen-presenting capacity of DCs in vitro. These data validate PI as a pluripotent inhibitor that can be applied mucosally as well as systemically. Its compelling functions render PI a promising novel physiological immune suppressant.
Keywords
Immune suppression, Inflammatory bowel disease, PHOSPHATIDYLCHOLINE, REGULATORY T-CELLS, TNBS-INDUCED COLITIS, TRANSFER PROTEIN-ALPHA, INFLAMMATORY-BOWEL-DISEASE, T cells, Regulation, Phospholipids, MODEL, SUPPRESSION, INDUCTION, TOLERANCE, INTESTINE

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MLA
van Dieren, Jolanda M., et al. “Anti-Inflammatory Actions of Phosphatidylinositol.” EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 41, no. 4, 2011, pp. 1047–57, doi:10.1002/eji.201040899.
APA
van Dieren, J. M., Simons-Oosterhuis, Y., Raatgeep, H. (Rolien), Lindenbergh-Kortleve, D. J., Lambers, M. E., van der Woude, C. J., … Nieuwenhuis, E. E. (2011). Anti-inflammatory actions of phosphatidylinositol. EUROPEAN JOURNAL OF IMMUNOLOGY, 41(4), 1047–1057. https://doi.org/10.1002/eji.201040899
Chicago author-date
Dieren, Jolanda M van, Ytje Simons-Oosterhuis, HC (Rolien) Raatgeep, Dicky J Lindenbergh-Kortleve, Margaretha EH Lambers, C Janneke van der Woude, Ernst J Kuipers, et al. 2011. “Anti-Inflammatory Actions of Phosphatidylinositol.” EUROPEAN JOURNAL OF IMMUNOLOGY 41 (4): 1047–57. https://doi.org/10.1002/eji.201040899.
Chicago author-date (all authors)
van Dieren, Jolanda M, Ytje Simons-Oosterhuis, HC (Rolien) Raatgeep, Dicky J Lindenbergh-Kortleve, Margaretha EH Lambers, C Janneke van der Woude, Ernst J Kuipers, Gerry T Snoek, Ron Potman, Hamida Hammad, Bart Lambrecht, Janneke N Samsom, and Edward ES Nieuwenhuis. 2011. “Anti-Inflammatory Actions of Phosphatidylinositol.” EUROPEAN JOURNAL OF IMMUNOLOGY 41 (4): 1047–1057. doi:10.1002/eji.201040899.
Vancouver
1.
van Dieren JM, Simons-Oosterhuis Y, Raatgeep H (Rolien), Lindenbergh-Kortleve DJ, Lambers ME, van der Woude CJ, et al. Anti-inflammatory actions of phosphatidylinositol. EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(4):1047–57.
IEEE
[1]
J. M. van Dieren et al., “Anti-inflammatory actions of phosphatidylinositol,” EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 41, no. 4, pp. 1047–1057, 2011.
@article{1996980,
  abstract     = {{Chronic inflammatory T-cell-mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T-cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less-toxic alternatives. We aimed to investigate the immunoregulatory capacities of the naturally occurring phospholipid phosphatidylinositol (PI). Systemic PI treatment dramatically reduced disease severity and intestinal inflammation in murine 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis. Moreover, PI treatment inhibited the inflammatory T-cell response in these mice, as T cells derived from colon-draining LN of PI-treated mice secreted less IL-17 and IFN-gamma upon polyclonal restimulation when compared to those of saline-treated mice. Further characterization of the suppressive capacity of PI revealed that the phospholipid suppressed Th cell differentiation in vitro irrespective of their cytokine profile by inhibiting proliferation and IL-2 release. In particular, PI diminished IL-2 mRNA expression and inhibited ERK1-, ERK-2-, p38- and JNK-phosphorylation. Crucially, PI did not ablate Treg differentiation or the antigen-presenting capacity of DCs in vitro. These data validate PI as a pluripotent inhibitor that can be applied mucosally as well as systemically. Its compelling functions render PI a promising novel physiological immune suppressant.}},
  author       = {{van Dieren, Jolanda M and Simons-Oosterhuis, Ytje and Raatgeep, HC (Rolien) and Lindenbergh-Kortleve, Dicky J and Lambers, Margaretha EH and van der Woude, C Janneke and Kuipers, Ernst J and Snoek, Gerry T and Potman, Ron and Hammad, Hamida and Lambrecht, Bart and Samsom, Janneke N and Nieuwenhuis, Edward ES}},
  issn         = {{0014-2980}},
  journal      = {{EUROPEAN JOURNAL OF IMMUNOLOGY}},
  keywords     = {{Immune suppression,Inflammatory bowel disease,PHOSPHATIDYLCHOLINE,REGULATORY T-CELLS,TNBS-INDUCED COLITIS,TRANSFER PROTEIN-ALPHA,INFLAMMATORY-BOWEL-DISEASE,T cells,Regulation,Phospholipids,MODEL,SUPPRESSION,INDUCTION,TOLERANCE,INTESTINE}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1047--1057}},
  title        = {{Anti-inflammatory actions of phosphatidylinositol}},
  url          = {{http://doi.org/10.1002/eji.201040899}},
  volume       = {{41}},
  year         = {{2011}},
}
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