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TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways

Frédèric Perros (UGent) , Bart Lambrecht (UGent) and Hamida Hammad (UGent)
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Abstract
Inflammation of the airways, which is often associated with life-threatening infection by Gram-negative bacteria or presence of endotoxin in the bioaerosol, is still a major cause of severe airway diseases. Moreover, inhaled endotoxin may play an important role in the development and progression of airway inflammation in asthma. Pathologic changes induced by endotoxin inhalation include bronchospasm, airflow obstruction, recruitment of inflammatory cells, injury of the alveolar epithelium, and disruption of pulmonary capillary integrity leading to protein rich fluid leak in the alveolar space. Mammalian Toll-like receptors (TLRs) are important signalling receptors in innate host defense. Among these receptors, TLR4 plays a critical role in the response to endotoxin. Lungs are a complex compartmentalized organ with separate barriers, namely the alveolar-capillary barrier, the microvascular endothelium, and the alveolar epithelium. An emerging theme in the field of lung immunology is that structural cells (SCs) of the airways such as epithelial cells (ECs), endothelial cells, fibroblasts and other stromal cells produce activating cytokines that determine the quantity and quality of the lung immune response. This review focuses on the role of TLR4 in the innate and adaptive immune functions of the pulmonary SCs.
Keywords
pulmonary stromal cells, TLR4, dendritic cells, epithelial cell, Airway diseases, TOLL-LIKE RECEPTORS, NF-KAPPA-B, DOMAIN-CONTAINING ADAPTER, LPS-INDUCED ACTIVATION, MARROW-DERIVED CELLS, ACUTE LUNG INJURY, EPITHELIAL-CELLS, DENDRITIC CELLS, NEUTROPHIL SEQUESTRATION, INHALED ENDOTOXIN

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Chicago
Perros, Frédèric, Bart Lambrecht, and Hamida Hammad. 2011. “TLR4 Signalling in Pulmonary Stromal Cells Is Critical for Inflammation and Immunity in the Airways.” Respiratory Research 12.
APA
Perros, F., Lambrecht, B., & Hammad, H. (2011). TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways. RESPIRATORY RESEARCH, 12.
Vancouver
1.
Perros F, Lambrecht B, Hammad H. TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways. RESPIRATORY RESEARCH. 2011;12.
MLA
Perros, Frédèric, Bart Lambrecht, and Hamida Hammad. “TLR4 Signalling in Pulmonary Stromal Cells Is Critical for Inflammation and Immunity in the Airways.” RESPIRATORY RESEARCH 12 (2011): n. pag. Print.
@article{1996929,
  abstract     = {Inflammation of the airways, which is often associated with life-threatening infection by Gram-negative bacteria or presence of endotoxin in the bioaerosol, is still a major cause of severe airway diseases. Moreover, inhaled endotoxin may play an important role in the development and progression of airway inflammation in asthma. Pathologic changes induced by endotoxin inhalation include bronchospasm, airflow obstruction, recruitment of inflammatory cells, injury of the alveolar epithelium, and disruption of pulmonary capillary integrity leading to protein rich fluid leak in the alveolar space. Mammalian Toll-like receptors (TLRs) are important signalling receptors in innate host defense. Among these receptors, TLR4 plays a critical role in the response to endotoxin. Lungs are a complex compartmentalized organ with separate barriers, namely the alveolar-capillary barrier, the microvascular endothelium, and the alveolar epithelium. An emerging theme in the field of lung immunology is that structural cells (SCs) of the airways such as epithelial cells (ECs), endothelial cells, fibroblasts and other stromal cells produce activating cytokines that determine the quantity and quality of the lung immune response. This review focuses on the role of TLR4 in the innate and adaptive immune functions of the pulmonary SCs.},
  articleno    = {125},
  author       = {Perros, Fr{\'e}d{\`e}ric and Lambrecht, Bart and Hammad, Hamida},
  issn         = {1465-993X},
  journal      = {RESPIRATORY RESEARCH},
  keyword      = {pulmonary stromal cells,TLR4,dendritic cells,epithelial cell,Airway diseases,TOLL-LIKE RECEPTORS,NF-KAPPA-B,DOMAIN-CONTAINING ADAPTER,LPS-INDUCED ACTIVATION,MARROW-DERIVED CELLS,ACUTE LUNG INJURY,EPITHELIAL-CELLS,DENDRITIC CELLS,NEUTROPHIL SEQUESTRATION,INHALED ENDOTOXIN},
  language     = {eng},
  pages        = {8},
  title        = {TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways},
  url          = {http://dx.doi.org/10.1186/1465-9921-12-125},
  volume       = {12},
  year         = {2011},
}

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