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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

L Galluzzi, I Vitale, JM Abrams, ES Alnemri, EH Baehrecke, MV Blagosklonny, TM Dawson, VL Dawson, WS El-Deiry and S Fulda, et al. (2012) CELL DEATH AND DIFFERENTIATION. 19(1). p.107-120
abstract
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including 'apoptosis', 'necrosis' and 'mitotic catastrophe'. In view of the substantial progress in the biochemical and genetic exploration of cell death, time has come to switch from morphological to molecular definitions of cell death modalities. Here we propose a functional classification of cell death subroutines that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic apoptosis, regulated necrosis, autophagic cell death and mitotic catastrophe. Moreover, we discuss the utility of expressions indicating additional cell death modalities. On the basis of the new, revised NCCD classification, cell death subroutines are defined by a series of precise, measurable biochemical features.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
TNFR1, TP53, necroptosis, mitochondrial membrane permeabilization, parthanatos, autophagy, APOPTOSIS-INDUCING FACTOR, MITOCHONDRIAL-MEMBRANE PERMEABILIZATION, NEUTROPHIL EXTRACELLULAR TRAPS, POLY(ADP-RIBOSE) PAR POLYMER, CASPASE-MEDIATED CLEAVAGE, STRESS-INDUCED APOPTOSIS, BREAST-CANCER CELLS, NECROSIS-FACTOR TNF, MITOTIC CATASTROPHE, CYTOCHROME-C
journal title
CELL DEATH AND DIFFERENTIATION
Cell Death Differ.
volume
19
issue
1
pages
107 - 120
Web of Science type
Review
Web of Science id
000298369000014
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
8.371 (2012)
JCR rank
26/288 (2012)
JCR quartile
1 (2012)
ISSN
1350-9047
DOI
10.1038/cdd.2011.96
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1996685
handle
http://hdl.handle.net/1854/LU-1996685
date created
2012-01-19 13:58:23
date last changed
2012-06-26 14:32:35
@article{1996685,
  abstract     = {In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including 'apoptosis', 'necrosis' and 'mitotic catastrophe'. In view of the substantial progress in the biochemical and genetic exploration of cell death, time has come to switch from morphological to molecular definitions of cell death modalities. Here we propose a functional classification of cell death subroutines that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic apoptosis, regulated necrosis, autophagic cell death and mitotic catastrophe. Moreover, we discuss the utility of expressions indicating additional cell death modalities. On the basis of the new, revised NCCD classification, cell death subroutines are defined by a series of precise, measurable biochemical features.},
  author       = {Galluzzi, L and Vitale, I and Abrams, JM and Alnemri, ES and Baehrecke, EH and Blagosklonny, MV and Dawson, TM and Dawson, VL and El-Deiry, WS and Fulda, S and Gottlieb, E and Green, DR and Hengartner, MO and Kepp, O and Knight, RA and Kumar, S and Lipton, SA and Lu, X and Madeo, F and Malorni, W and Mehlen, P and Nu{\~n}ez, G and Peter, ME and Piacentini, M and Rubinsztein, DC and Shi, Y and Simon, HU and Vandenabeele, Peter and White, E and Yuan, J and Zhivotovsky, B and Melino, G and Kroemer, G},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  keyword      = {TNFR1,TP53,necroptosis,mitochondrial membrane permeabilization,parthanatos,autophagy,APOPTOSIS-INDUCING FACTOR,MITOCHONDRIAL-MEMBRANE PERMEABILIZATION,NEUTROPHIL EXTRACELLULAR TRAPS,POLY(ADP-RIBOSE) PAR POLYMER,CASPASE-MEDIATED CLEAVAGE,STRESS-INDUCED APOPTOSIS,BREAST-CANCER CELLS,NECROSIS-FACTOR TNF,MITOTIC CATASTROPHE,CYTOCHROME-C},
  language     = {eng},
  number       = {1},
  pages        = {107--120},
  title        = {Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012},
  url          = {http://dx.doi.org/10.1038/cdd.2011.96},
  volume       = {19},
  year         = {2012},
}

Chicago
Galluzzi, L, I Vitale, JM Abrams, ES Alnemri, EH Baehrecke, MV Blagosklonny, TM Dawson, et al. 2012. “Molecular Definitions of Cell Death Subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012.” Cell Death and Differentiation 19 (1): 107–120.
APA
Galluzzi, L, Vitale, I., Abrams, J., Alnemri, E., Baehrecke, E., Blagosklonny, M., Dawson, T., et al. (2012). Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. CELL DEATH AND DIFFERENTIATION, 19(1), 107–120.
Vancouver
1.
Galluzzi L, Vitale I, Abrams J, Alnemri E, Baehrecke E, Blagosklonny M, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. CELL DEATH AND DIFFERENTIATION. 2012;19(1):107–20.
MLA
Galluzzi, L, I Vitale, JM Abrams, et al. “Molecular Definitions of Cell Death Subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012.” CELL DEATH AND DIFFERENTIATION 19.1 (2012): 107–120. Print.