Ghent University Academic Bibliography

Advanced

Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine: a review

Uta Eberlein, Jörn Hendrik Bröer, Charlot Vandevoorde UGent, Paula Santos, Manuel Bardiès, Klaus Bacher UGent, Dietmar Nosske and Michael Lassmann (2011) EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 38(12). p.2269-2281
abstract
Purpose The impact on patients' health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE. NET (www.peddose.net), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals. Methods A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (www.ncbi.nlm.nih.gov/pubmed). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting. Results Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago. Conclusion It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
F-18 FLUORIDE, BLADDER WALL, HUMAN BIODISTRIBUTION, RADIATION-DOSIMETRY, WHOLE-BODY PET, NON-HODGKINS-LYMPHOMA, PERSONAL-COMPUTER SOFTWARE, METASTATIC NEUROENDOCRINE TUMORS, INTERNAL DOSE ASSESSMENT, POSITRON-EMISSION-TOMOGRAPHY, Effective dose, Diagnostic radiopharmaceuticals, Dosimetry, Biokinetics
journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Eur. J. Nucl. Med. Mol. Imaging
volume
38
issue
12
pages
2269 - 2281
Web of Science type
Review
Web of Science id
000297732700019
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.991 (2011)
JCR rank
8/116 (2011)
JCR quartile
1 (2011)
ISSN
1619-7070
DOI
10.1007/s00259-011-1904-z
project
PEDDOSE.NET (Dosimetry and Health Effects of Diagnostic Applications of Radiopharmaceuticals with particular emphasis on the use in children and adolescents)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1995760
handle
http://hdl.handle.net/1854/LU-1995760
date created
2012-01-19 09:22:27
date last changed
2012-04-19 14:37:14
@article{1995760,
  abstract     = {Purpose The impact on patients' health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE. NET (www.peddose.net), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals. 
Methods A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (www.ncbi.nlm.nih.gov/pubmed). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting. 
Results Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago. 
Conclusion It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.},
  author       = {Eberlein, Uta  and Br{\"o}er, J{\"o}rn Hendrik and Vandevoorde, Charlot and Santos, Paula  and Bardi{\`e}s, Manuel  and Bacher, Klaus and Nosske, Dietmar  and Lassmann, Michael},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {F-18 FLUORIDE,BLADDER WALL,HUMAN BIODISTRIBUTION,RADIATION-DOSIMETRY,WHOLE-BODY PET,NON-HODGKINS-LYMPHOMA,PERSONAL-COMPUTER SOFTWARE,METASTATIC NEUROENDOCRINE TUMORS,INTERNAL DOSE ASSESSMENT,POSITRON-EMISSION-TOMOGRAPHY,Effective dose,Diagnostic radiopharmaceuticals,Dosimetry,Biokinetics},
  language     = {eng},
  number       = {12},
  pages        = {2269--2281},
  title        = {Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine: a review},
  url          = {http://dx.doi.org/10.1007/s00259-011-1904-z},
  volume       = {38},
  year         = {2011},
}

Chicago
Eberlein, Uta , Jörn Hendrik Bröer, Charlot Vandevoorde, Paula Santos, Manuel Bardiès, Klaus Bacher, Dietmar Nosske, and Michael Lassmann. 2011. “Biokinetics and Dosimetry of Commonly Used Radiopharmaceuticals in Diagnostic Nuclear Medicine: a Review.” European Journal of Nuclear Medicine and Molecular Imaging 38 (12): 2269–2281.
APA
Eberlein, U., Bröer, J. H., Vandevoorde, C., Santos, P., Bardiès, M., Bacher, K., Nosske, D., et al. (2011). Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine: a review. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 38(12), 2269–2281.
Vancouver
1.
Eberlein U, Bröer JH, Vandevoorde C, Santos P, Bardiès M, Bacher K, et al. Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine: a review. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38(12):2269–81.
MLA
Eberlein, Uta , Jörn Hendrik Bröer, Charlot Vandevoorde, et al. “Biokinetics and Dosimetry of Commonly Used Radiopharmaceuticals in Diagnostic Nuclear Medicine: a Review.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 38.12 (2011): 2269–2281. Print.