Ghent University Academic Bibliography

Advanced

The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes

I Vercruysse, An Vermeulen UGent, Frans Belpaire, DL Massart and AG Dupont (1994) FUNDAMENTAL & CLINICAL PHARMACOLOGY. 8(4). p.373-378
abstract
The influence of the dihydropyridine calcium entry blockers nicardipine, amlodipine, nifedipine, isradipine and of the dihydropyridine calcium entry promotor BAY K 8644 on the disappearance rate of propranolol by isolated rat hepatocytes was compared to the effect of diltiazem and verapamil, two non-dihydropyridine calcium channel blockers and known inhibitors of hepatic cytochrome P450 mixed function oxidases. All compounds dose-dependently inhibited the disappearance rate of propranolol. Nicardipine and isradipine were more potent in inhibiting the disappearance rate of propranolol than the other dihydropyridines and than diltiazem and verapamil. The inhibitory effect of nicardipine on the disappearance rate of propranolol was not stereoselective and was not influenced by age.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PROPRANOLOL METABOLISM, RAT HEPATOCYTES, CALCIUM ANTAGONISTS, CALCIUM AGONIST, AGING, PHARMACOKINETICS, NICARDIPINE, PHARMACODYNAMICS, METOPROLOL, ATENOLOL, LIVER
journal title
FUNDAMENTAL & CLINICAL PHARMACOLOGY
Fundam. Clin. Pharmacol.
volume
8
issue
4
pages
373 - 378
Web of Science type
Article
ISSN
0767-3981
DOI
10.1111/j.1472-8206.1994.tb00815.x
language
English
UGent publication?
yes
classification
A1
id
199353
handle
http://hdl.handle.net/1854/LU-199353
date created
2004-01-14 13:42:00
date last changed
2017-03-10 09:20:03
@article{199353,
  abstract     = {The influence of the dihydropyridine calcium entry blockers nicardipine, amlodipine, nifedipine, isradipine and of the dihydropyridine calcium entry promotor BAY K 8644 on the disappearance rate of propranolol by isolated rat hepatocytes was compared to the effect of diltiazem and verapamil, two non-dihydropyridine calcium channel blockers and known inhibitors of hepatic cytochrome P450 mixed function oxidases. All compounds dose-dependently inhibited the disappearance rate of propranolol. Nicardipine and isradipine were more potent in inhibiting the disappearance rate of propranolol than the other dihydropyridines and than diltiazem and verapamil. The inhibitory effect of nicardipine on the disappearance rate of propranolol was not stereoselective and was not influenced by age.},
  author       = {Vercruysse, I and Vermeulen, An and Belpaire, Frans and Massart, DL and Dupont, AG},
  issn         = {0767-3981},
  journal      = {FUNDAMENTAL \& CLINICAL PHARMACOLOGY},
  keyword      = {PROPRANOLOL METABOLISM,RAT HEPATOCYTES,CALCIUM ANTAGONISTS,CALCIUM AGONIST,AGING,PHARMACOKINETICS,NICARDIPINE,PHARMACODYNAMICS,METOPROLOL,ATENOLOL,LIVER},
  language     = {eng},
  number       = {4},
  pages        = {373--378},
  title        = {The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes},
  url          = {http://dx.doi.org/10.1111/j.1472-8206.1994.tb00815.x},
  volume       = {8},
  year         = {1994},
}

Chicago
Vercruysse, I, An Vermeulen, Frans Belpaire, DL Massart, and AG Dupont. 1994. “The Effect of Different Calcium-antagonists and a Calcium Agonist on the Metabolism of Propranolol by Isolated Rat Hepatocytes.” Fundamental & Clinical Pharmacology 8 (4): 373–378.
APA
Vercruysse, I., Vermeulen, A., Belpaire, F., Massart, D., & Dupont, A. (1994). The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 8(4), 373–378.
Vancouver
1.
Vercruysse I, Vermeulen A, Belpaire F, Massart D, Dupont A. The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes. FUNDAMENTAL & CLINICAL PHARMACOLOGY. 1994;8(4):373–8.
MLA
Vercruysse, I, An Vermeulen, Frans Belpaire, et al. “The Effect of Different Calcium-antagonists and a Calcium Agonist on the Metabolism of Propranolol by Isolated Rat Hepatocytes.” FUNDAMENTAL & CLINICAL PHARMACOLOGY 8.4 (1994): 373–378. Print.