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A 92-kDa human immunostimulatory protein

Elisabeth Fontan, Emmanuel Briend, Hélène Saklani-Jusforgues, Jacques d'Alayer, Joël Vandekerckhove and Robert M Fauve (1994) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 91(18). p.8353-8357
abstract
We purified to apparent homogeneity a human urinary glycoprotein of 92 kDa (HGP.92) that, administered intravenously at 250 mu g/kg, fully protected mice against a lethal inoculum of Listeria monocytogenes. Since HGP.92 protected scid mice, which lack B and T lymphocytes, this increased resistance to Listeria did not appear to be lymphocyte mediated. Furthermore, inflammatory macrophages incubated with 6 nM HGP.92 inhibited the growth of Lewis carcinoma cells in vitro. These two activities appeared to depend on an oligosaccharide moiety, as they were lost after N-Glycanase treatment of HGP.92. Thus, the biological activity of HGP.92 was in some way related to a glycan moiety.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SERUM, KIDNEY, IDENTIFICATION, UROMODULIN, HUMAN-PREGNANCY URINE, HUMAN URINARY PROTEIN, TAMM-HORSFALL GLYCOPROTEIN, LEWIS CARCINOMA, LISTERIA MONOCYTOGENES, MACROPHAGES, SCID MICE, URINE
journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proc. Natl. Acad. Sci. USA
volume
91
issue
18
pages
8353 - 8357
Web of Science type
Article
ISSN
0027-8424
DOI
10.1073/pnas.91.18.8353
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
199137
handle
http://hdl.handle.net/1854/LU-199137
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:38:50
@article{199137,
  abstract     = {We purified to apparent homogeneity a human urinary glycoprotein of 92 kDa (HGP.92) that, administered intravenously at 250 mu g/kg, fully protected mice against a lethal inoculum of Listeria monocytogenes. Since HGP.92 protected scid mice, which lack B and T lymphocytes, this increased resistance to Listeria did not appear to be lymphocyte mediated. Furthermore, inflammatory macrophages incubated with 6 nM HGP.92 inhibited the growth of Lewis carcinoma cells in vitro. These two activities appeared to depend on an oligosaccharide moiety, as they were lost after N-Glycanase treatment of HGP.92. Thus, the biological activity of HGP.92 was in some way related to a glycan moiety.},
  author       = {Fontan, Elisabeth and Briend, Emmanuel and Saklani-Jusforgues, H{\'e}l{\`e}ne and d'Alayer, Jacques and Vandekerckhove, Jo{\"e}l and Fauve, Robert M},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  keyword      = {SERUM,KIDNEY,IDENTIFICATION,UROMODULIN,HUMAN-PREGNANCY URINE,HUMAN URINARY PROTEIN,TAMM-HORSFALL GLYCOPROTEIN,LEWIS CARCINOMA,LISTERIA MONOCYTOGENES,MACROPHAGES,SCID MICE,URINE},
  language     = {eng},
  number       = {18},
  pages        = {8353--8357},
  title        = {A 92-kDa human immunostimulatory protein},
  url          = {http://dx.doi.org/10.1073/pnas.91.18.8353},
  volume       = {91},
  year         = {1994},
}

Chicago
Fontan, Elisabeth, Emmanuel Briend, Hélène Saklani-Jusforgues, Jacques d’ Alayer, Joël Vandekerckhove, and Robert M Fauve. 1994. “A 92-kDa Human Immunostimulatory Protein.” Proceedings of the National Academy of Sciences of the United States of America 91 (18): 8353–8357.
APA
Fontan, E., Briend, E., Saklani-Jusforgues, H., d’ Alayer, J., Vandekerckhove, J., & Fauve, R. M. (1994). A 92-kDa human immunostimulatory protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 91(18), 8353–8357.
Vancouver
1.
Fontan E, Briend E, Saklani-Jusforgues H, d’ Alayer J, Vandekerckhove J, Fauve RM. A 92-kDa human immunostimulatory protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1994;91(18):8353–7.
MLA
Fontan, Elisabeth, Emmanuel Briend, Hélène Saklani-Jusforgues, et al. “A 92-kDa Human Immunostimulatory Protein.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91.18 (1994): 8353–8357. Print.