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Functional analysis of vascular dysfunction in cyclosporin-treated rats

Marleen Verbeke (UGent) , Johan Van de Voorde (UGent) , Leo De Ridder (UGent) and Norbert Lameire (UGent)
(1994) CARDIOVASCULAR RESEARCH. 28(8). p.1152-1156
Author
Organization
Abstract
Objective: The aim was to analyse vascular damage after chronic cyclosporin treatment (20 mg.kg(-1) during 10 d) in rats. Methods: The reactivity to different vasoactive agents was studied on thoracic aortic rings from control rats, and from rats subjected to renal ablation or cyclosporin treatment. Results: After cyclosporin treatment the endothelium dependent vasodilator responses to acetylcholine and to the endothelium independent NO donors were suppressed. These defects were restored after a 7 d recovery period. The contractile response after inhibition of basal endothelial NO synthesis was unaffected. Further analysis of the blunted vasodilatations not only points to impairments of cGMP mediated mechanisms but shows that other pathways are possibly involved as well. Renal insufficiency induced by renal mass reduction did not influence the aortic reactivity. Conclusions: Cyclosporin induced vasculotoxicity is a reversible phenomenon, and is not due to renal dysfunction as such. It seems to provoke a defect in the vasodilator mechanisms at the level of the vascular smooth muscle cells and most likely no impairment of endothelial nitric oxide production.
Keywords
AORTA, CYCLOSPORINE, NITRIC OXIDE, ENDOTHELIUM, SMOOTH MUSCLE CELLS, NEPHROTOXICITY, HEMODYNAMICS, RELAXATION, REACTIVITY, RESPONSES, VERAPAMIL, RELEASE, KIDNEY, AORTA

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Chicago
Verbeke, Marleen, Johan Van de Voorde, Leo De Ridder, and Norbert Lameire. 1994. “Functional Analysis of Vascular Dysfunction in Cyclosporin-treated Rats.” Cardiovascular Research 28 (8): 1152–1156.
APA
Verbeke, Marleen, Van de Voorde, J., De Ridder, L., & Lameire, N. (1994). Functional analysis of vascular dysfunction in cyclosporin-treated rats. CARDIOVASCULAR RESEARCH, 28(8), 1152–1156.
Vancouver
1.
Verbeke M, Van de Voorde J, De Ridder L, Lameire N. Functional analysis of vascular dysfunction in cyclosporin-treated rats. CARDIOVASCULAR RESEARCH. 1994;28(8):1152–6.
MLA
Verbeke, Marleen, Johan Van de Voorde, Leo De Ridder, et al. “Functional Analysis of Vascular Dysfunction in Cyclosporin-treated Rats.” CARDIOVASCULAR RESEARCH 28.8 (1994): 1152–1156. Print.
@article{198957,
  abstract     = {Objective: The aim was to analyse vascular damage after chronic cyclosporin treatment (20 mg.kg(-1) during 10 d) in rats.
Methods: The reactivity to different vasoactive agents was studied on thoracic aortic rings from control rats, and from rats subjected to renal ablation or cyclosporin treatment.
Results: After cyclosporin treatment the endothelium dependent vasodilator responses to acetylcholine and to the endothelium independent NO donors were suppressed. These defects were restored after a 7 d recovery period. The contractile response after inhibition of basal endothelial NO synthesis was unaffected. Further analysis of the blunted vasodilatations not only points to impairments of cGMP mediated mechanisms but shows that other pathways are possibly involved as well. Renal insufficiency induced by renal mass reduction did not influence the aortic reactivity.
Conclusions: Cyclosporin induced vasculotoxicity is a reversible phenomenon, and is not due to renal dysfunction as such. It seems to provoke a defect in the vasodilator mechanisms at the level of the vascular smooth muscle cells and most likely no impairment of endothelial nitric oxide production.},
  author       = {Verbeke, Marleen and Van de Voorde, Johan and De Ridder, Leo and Lameire, Norbert},
  issn         = {0008-6363},
  journal      = {CARDIOVASCULAR RESEARCH},
  keyword      = {AORTA,CYCLOSPORINE,NITRIC OXIDE,ENDOTHELIUM,SMOOTH MUSCLE CELLS,NEPHROTOXICITY,HEMODYNAMICS,RELAXATION,REACTIVITY,RESPONSES,VERAPAMIL,RELEASE,KIDNEY,AORTA},
  language     = {eng},
  number       = {8},
  pages        = {1152--1156},
  title        = {Functional analysis of vascular dysfunction in cyclosporin-treated rats},
  url          = {http://dx.doi.org/10.1093/cvr/28.8.1152},
  volume       = {28},
  year         = {1994},
}

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