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Necrotic enteritis in broilers: an updated review on the pathogenesis

Leen Timbermont UGent, Freddy Haesebrouck UGent, Richard Ducatelle UGent and Filip Van Immerseel UGent (2011) AVIAN PATHOLOGY. 40(4). p.341-347
abstract
Clostridium perfringens-induced necrotic enteritis and related subclinical disease have become economically significant problems for the broiler industry. Fortunately, scientific interest in this topic has grown: new C. perfringens virulence factors have been discovered and new insight gained about the pathogenesis of necrotic enteritis. It has been shown that alpha toxin, for a long time thought to be the key virulence factor, is not essential for the development of the disease. Moreover, it is now clearly established that only certain C. perfringens strains are capable of inducing necrotic enteritis under specific conditions that predispose to the disease and they constitute only a minority in the intestinal tract of healthy chickens. A novel pore-forming toxin, NetB, has been identified in these virulent avian C. perfringens strains. Using a gene knockout mutant, it has been shown that NetB is a critical virulence factor in the pathogenesis of necrotic enteritis in broilers. In addition to toxin production, other factors have been described that contribute to the ability of certain C. perfringens strains to cause necrotic enteritis in broilers. It has been suggested that proteolytic enzymes play an important role in the initial stages of necrotic enteritis since the villi are first affected at the level of the basement membrane and the lateral domain of the enterocytes. In field outbreaks of necrotic enteritis, a single clone of C. perfringens is dominant in intestines of all affected birds, as opposed to the mixture of different C. perfringens strains that can be isolated from healthy bird intestines. It has been proposed that bacteriocin production is responsible for the dominance of a single strain in necrotic enteritis cases. Furthermore, it has been shown that virulent strains are more able to adhere to extracellular matrix molecules than non-virulent strains. The current knowledge on the pathogenesis of the disease has been summarized in this short review.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
pathogenesis, CLOSTRIDIUM-PERFRINGENS STRAINS, Clostridium perfringens, broiler, Necrotic enteritis, ALPHA-TOXIN, AVOPARCIN SUPPLEMENTATION, BARLEY INCLUSION, GAS-GANGRENE, NETB TOXIN, CHICKENS, DISEASE, POULTRY, DIET
journal title
AVIAN PATHOLOGY
Avian Pathol.
volume
40
issue
4
pages
341 - 347
Web of Science type
Review
Web of Science id
000295319600001
JCR category
VETERINARY SCIENCES
JCR impact factor
1.711 (2011)
JCR rank
26/141 (2011)
JCR quartile
1 (2011)
ISSN
0307-9457
DOI
10.1080/03079457.2011.590967
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1988347
handle
http://hdl.handle.net/1854/LU-1988347
date created
2012-01-17 08:54:41
date last changed
2012-01-31 11:01:04
@article{1988347,
  abstract     = {Clostridium perfringens-induced necrotic enteritis and related subclinical disease have become economically significant problems for the broiler industry. Fortunately, scientific interest in this topic has grown: new C. perfringens virulence factors have been discovered and new insight gained about the pathogenesis of necrotic enteritis. It has been shown that alpha toxin, for a long time thought to be the key virulence factor, is not essential for the development of the disease. Moreover, it is now clearly established that only certain C. perfringens strains are capable of inducing necrotic enteritis under specific conditions that predispose to the disease and they constitute only a minority in the intestinal tract of healthy chickens. A novel pore-forming toxin, NetB, has been identified in these virulent avian C. perfringens strains. Using a gene knockout mutant, it has been shown that NetB is a critical virulence factor in the pathogenesis of necrotic enteritis in broilers. In addition to toxin production, other factors have been described that contribute to the ability of certain C. perfringens strains to cause necrotic enteritis in broilers. It has been suggested that proteolytic enzymes play an important role in the initial stages of necrotic enteritis since the villi are first affected at the level of the basement membrane and the lateral domain of the enterocytes. In field outbreaks of necrotic enteritis, a single clone of C. perfringens is dominant in intestines of all affected birds, as opposed to the mixture of different C. perfringens strains that can be isolated from healthy bird intestines. It has been proposed that bacteriocin production is responsible for the dominance of a single strain in necrotic enteritis cases. Furthermore, it has been shown that virulent strains are more able to adhere to extracellular matrix molecules than non-virulent strains. The current knowledge on the pathogenesis of the disease has been summarized in this short review.},
  author       = {Timbermont, Leen and Haesebrouck, Freddy and Ducatelle, Richard and Van Immerseel, Filip},
  issn         = {0307-9457},
  journal      = {AVIAN PATHOLOGY},
  keyword      = {pathogenesis,CLOSTRIDIUM-PERFRINGENS STRAINS,Clostridium perfringens,broiler,Necrotic enteritis,ALPHA-TOXIN,AVOPARCIN SUPPLEMENTATION,BARLEY INCLUSION,GAS-GANGRENE,NETB TOXIN,CHICKENS,DISEASE,POULTRY,DIET},
  language     = {eng},
  number       = {4},
  pages        = {341--347},
  title        = {Necrotic enteritis in broilers: an updated review on the pathogenesis},
  url          = {http://dx.doi.org/10.1080/03079457.2011.590967},
  volume       = {40},
  year         = {2011},
}

Chicago
Timbermont, Leen, Freddy Haesebrouck, Richard Ducatelle, and Filip Van Immerseel. 2011. “Necrotic Enteritis in Broilers: An Updated Review on the Pathogenesis.” Avian Pathology 40 (4): 341–347.
APA
Timbermont, L., Haesebrouck, F., Ducatelle, R., & Van Immerseel, F. (2011). Necrotic enteritis in broilers: an updated review on the pathogenesis. AVIAN PATHOLOGY, 40(4), 341–347.
Vancouver
1.
Timbermont L, Haesebrouck F, Ducatelle R, Van Immerseel F. Necrotic enteritis in broilers: an updated review on the pathogenesis. AVIAN PATHOLOGY. 2011;40(4):341–7.
MLA
Timbermont, Leen, Freddy Haesebrouck, Richard Ducatelle, et al. “Necrotic Enteritis in Broilers: An Updated Review on the Pathogenesis.” AVIAN PATHOLOGY 40.4 (2011): 341–347. Print.