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Brain grey matter deficits in smokers: focus on the cerebellum

Simone Kühn UGent, Alexander Romanowski, Christina Schilling, Arian Mobascher, Tracy Warbrick, Georg Winterer and Jürgen Gallinat (2012) BRAIN STRUCTURE & FUNCTION. 217(2). p.517-522
abstract
Structural cerebral deficiencies in smokers have been well characterized by morphometric investigations focussing on cortical and subcortical structures. Although the role of the cerebellum is increasingly noted in mental and addiction disorders, no reports exist regarding cerebellar alterations in smokers employing a methodology specifically designed to assess the cerebellar morphology. We acquired high-resolution MRI scans from 33 heavy smokers and 22 never-smokers and used a voxel-based morphometry (VBM) approach utilizing the Spatially Unbiased Infratentorial (SUIT) toolbox (Diedrichsen 2006) to provide an optimized and fine-grained exploration of cerebellar structural alterations associated with smoking. Relative to never-smokers, smokers showed significant reductions of grey matter volume in the right cerebellum Crus I. The grey matter volume in Crus I correlated negatively with the amount of nicotine dependence as assessed by means of the Fagerstrom scale. Since Crus I has been identified as the cognitive division of the cerebellum, the structural deficit may in part mediate cognitive deficits previously reported in smokers. Of note, the dependence-related magnitude of the volume deficit may support the notion that the cerebellum is substantially involved in core mechanisms of drug dependence.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CEREBRAL-BLOOD-FLOW, CHRONIC CIGARETTE-SMOKING, COGNITIVE PERFORMANCE, NICOTINE DEPENDENCE, CARDIOVASCULAR HEALTH, TOBACCO SMOKERS, NONSMOKERS, VOLUMES, HISTORY, FMRI, Smoking, Nicotine, Cerebellum, Voxel-based morphometry, Addiction, SUIT toolbox
journal title
BRAIN STRUCTURE & FUNCTION
Brain Struct. Funct.
volume
217
issue
2
pages
517 - 522
Web of Science type
Article
Web of Science id
000302573200025
JCR category
ANATOMY & MORPHOLOGY
JCR impact factor
7.837 (2012)
JCR rank
1/20 (2012)
JCR quartile
1 (2012)
ISSN
1863-2653
DOI
10.1007/s00429-011-0346-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1987895
handle
http://hdl.handle.net/1854/LU-1987895
date created
2012-01-17 08:06:05
date last changed
2012-10-02 11:33:52
@article{1987895,
  abstract     = {Structural cerebral deficiencies in smokers have been well characterized by morphometric investigations focussing on cortical and subcortical structures. Although the role of the cerebellum is increasingly noted in mental and addiction disorders, no reports exist regarding cerebellar alterations in smokers employing a methodology specifically designed to assess the cerebellar morphology. We acquired high-resolution MRI scans from 33 heavy smokers and 22 never-smokers and used a voxel-based morphometry (VBM) approach utilizing the Spatially Unbiased Infratentorial (SUIT) toolbox (Diedrichsen 2006) to provide an optimized and fine-grained exploration of cerebellar structural alterations associated with smoking. Relative to never-smokers, smokers showed significant reductions of grey matter volume in the right cerebellum Crus I. The grey matter volume in Crus I correlated negatively with the amount of nicotine dependence as assessed by means of the Fagerstrom scale. Since Crus I has been identified as the cognitive division of the cerebellum, the structural deficit may in part mediate cognitive deficits previously reported in smokers. Of note, the dependence-related magnitude of the volume deficit may support the notion that the cerebellum is substantially involved in core mechanisms of drug dependence.},
  author       = {K{\"u}hn, Simone and Romanowski, Alexander  and Schilling, Christina  and Mobascher, Arian  and Warbrick, Tracy  and Winterer, Georg and Gallinat, J{\"u}rgen},
  issn         = {1863-2653},
  journal      = {BRAIN STRUCTURE \& FUNCTION},
  keyword      = {CEREBRAL-BLOOD-FLOW,CHRONIC CIGARETTE-SMOKING,COGNITIVE PERFORMANCE,NICOTINE DEPENDENCE,CARDIOVASCULAR HEALTH,TOBACCO SMOKERS,NONSMOKERS,VOLUMES,HISTORY,FMRI,Smoking,Nicotine,Cerebellum,Voxel-based morphometry,Addiction,SUIT toolbox},
  language     = {eng},
  number       = {2},
  pages        = {517--522},
  title        = {Brain grey matter deficits in smokers: focus on the cerebellum},
  url          = {http://dx.doi.org/10.1007/s00429-011-0346-5},
  volume       = {217},
  year         = {2012},
}

Chicago
Kühn, Simone, Alexander Romanowski, Christina Schilling, Arian Mobascher, Tracy Warbrick, Georg Winterer, and Jürgen Gallinat. 2012. “Brain Grey Matter Deficits in Smokers: Focus on the Cerebellum.” Brain Structure & Function 217 (2): 517–522.
APA
Kühn, S., Romanowski, A., Schilling, C., Mobascher, A., Warbrick, T., Winterer, G., & Gallinat, J. (2012). Brain grey matter deficits in smokers: focus on the cerebellum. BRAIN STRUCTURE & FUNCTION, 217(2), 517–522.
Vancouver
1.
Kühn S, Romanowski A, Schilling C, Mobascher A, Warbrick T, Winterer G, et al. Brain grey matter deficits in smokers: focus on the cerebellum. BRAIN STRUCTURE & FUNCTION. 2012;217(2):517–22.
MLA
Kühn, Simone, Alexander Romanowski, Christina Schilling, et al. “Brain Grey Matter Deficits in Smokers: Focus on the Cerebellum.” BRAIN STRUCTURE & FUNCTION 217.2 (2012): 517–522. Print.