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Pathogenesis of chronic rhinosinusitis: inflammation

Koen Van Crombruggen (UGent) , Nan Zhang (UGent) , Philippe Gevaert (UGent) , Peter Tomassen (UGent) and Claus Bachert (UGent)
Author
Organization
Abstract
Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory diseases of the nasal and paranasal cavities either accompanied by polyp formation (CRSwNP) or without polyps (CRSsNP). CRSsNP and CRSwNP are prevalent medical conditions associated with substantial impaired quality-of-live, reduced workplace productivity, and serious medical treatment costs. Despite recent research evidence that contributes to further unveil the pathophysiology of these chronic airway conditions, the etiology remains poorly understood and appears to be multifactorial. A diverse spectrum of alterations involving histopathology, inflammatory cell and T cell patterns, remodeling parameters such as TGF-β, eicosanoid and IgE production, microorganisms and epithelial barrier malfunctions is reported in the search to describe the pathogenesis of this heterogeneous group of upper airway diseases. Furthermore, novel evidence indicates considerable heterogeneity within the CRSwNP subgroup, determining the risk of co-morbid asthma. The characterization of specific disease subgroups is a challenging scientific and clinical task of utmost importance in the development of diagnostic tools and application of individualized treatments. This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of chronic rhinosinusitis in order to further unravel its pathogenesis.
Keywords
nasal polyps, remodeling, inflammation, S. aureus, IgE, chronic rhinosinusitis, eicosanoids, STAPHYLOCOCCUS-AUREUS, AUREUS ENTEROTOXIN-B, NASAL POLYPS, IGE ANTIBODIES, SINUS DISEASE, PROSTAGLANDIN, PHAGOCYTOSIS, RESPONSES, PROTEIN, ASTHMA

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MLA
Van Crombruggen, Koen, Nan Zhang, Philippe Gevaert, et al. “Pathogenesis of Chronic Rhinosinusitis: Inflammation.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 128.4 (2011): 728–732. Print.
APA
Van Crombruggen, K., Zhang, N., Gevaert, P., Tomassen, P., & Bachert, C. (2011). Pathogenesis of chronic rhinosinusitis: inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(4), 728–732.
Chicago author-date
Van Crombruggen, Koen, Nan Zhang, Philippe Gevaert, Peter Tomassen, and Claus Bachert. 2011. “Pathogenesis of Chronic Rhinosinusitis: Inflammation.” Journal of Allergy and Clinical Immunology 128 (4): 728–732.
Chicago author-date (all authors)
Van Crombruggen, Koen, Nan Zhang, Philippe Gevaert, Peter Tomassen, and Claus Bachert. 2011. “Pathogenesis of Chronic Rhinosinusitis: Inflammation.” Journal of Allergy and Clinical Immunology 128 (4): 728–732.
Vancouver
1.
Van Crombruggen K, Zhang N, Gevaert P, Tomassen P, Bachert C. Pathogenesis of chronic rhinosinusitis: inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;128(4):728–32.
IEEE
[1]
K. Van Crombruggen, N. Zhang, P. Gevaert, P. Tomassen, and C. Bachert, “Pathogenesis of chronic rhinosinusitis: inflammation,” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 128, no. 4, pp. 728–732, 2011.
@article{1987804,
  abstract     = {Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory diseases of the nasal and paranasal cavities either accompanied by polyp formation (CRSwNP) or without polyps (CRSsNP). CRSsNP and CRSwNP are prevalent medical conditions associated with substantial impaired quality-of-live, reduced workplace productivity, and serious medical treatment costs. Despite recent research evidence that contributes to further unveil the pathophysiology of these chronic airway conditions, the etiology remains poorly understood and appears to be multifactorial. A diverse spectrum of alterations involving histopathology, inflammatory cell and T cell patterns, remodeling parameters such as TGF-β, eicosanoid and IgE production, microorganisms and epithelial barrier malfunctions is reported in the search to describe the pathogenesis of this heterogeneous group of upper airway diseases. Furthermore, novel evidence indicates considerable heterogeneity within the CRSwNP subgroup, determining the risk of co-morbid asthma. The characterization of specific disease subgroups is a challenging scientific and clinical task of utmost importance in the development of diagnostic tools and application of individualized treatments. This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of chronic rhinosinusitis in order to further unravel its pathogenesis.},
  author       = {Van Crombruggen, Koen and Zhang, Nan and Gevaert, Philippe and Tomassen, Peter and Bachert, Claus},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keywords     = {nasal polyps,remodeling,inflammation,S. aureus,IgE,chronic rhinosinusitis,eicosanoids,STAPHYLOCOCCUS-AUREUS,AUREUS ENTEROTOXIN-B,NASAL POLYPS,IGE ANTIBODIES,SINUS DISEASE,PROSTAGLANDIN,PHAGOCYTOSIS,RESPONSES,PROTEIN,ASTHMA},
  language     = {eng},
  number       = {4},
  pages        = {728--732},
  title        = {Pathogenesis of chronic rhinosinusitis: inflammation},
  url          = {http://dx.doi.org/10.1016/j.jaci.2011.07.049},
  volume       = {128},
  year         = {2011},
}

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