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Thrombocytopenia and outcome in critically ill patients with bloodstream infection

Dominique Vandijck UGent, Stijn Blot UGent, Jan De Waele UGent, Eric Hoste UGent, Koenraad Vandewoude UGent and Johan Decruyenaere UGent (2010) HEART & LUNG. 39(1). p.21-26
abstract
OBJECTIVE: Thrombocytopenia is common in intensive care units (ICUs), and is associated with a poor prognosis. An acute decrease in total platelet count is frequently observed in severe sepsis, followed by a relative increase indicating organ-failure recovery. However, few data are available describing this effect and its relationship with outcomes in specific subgroups of ICU patients. METHODS: A retrospective, observational cohort study was conducted to investigate the incidence and prognosis of thrombocytopenia in a cohort of critically ill patients (n = 155) with a microbiologically documented nosocomial bloodstream infection. RESULTS: Thrombocytopenia occurred more frequently in nonsurvivors. The ICU mortality rates increased according to severity of thrombocytopenia. Thrombocytopenia was independently associated with worse outcomes in ICU patients with nosocomial bloodstream infection. CONCLUSION: Determining trends in platelet counts is of additional prognostic value, compared with single measurements.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ICU, ANTIMICROBIAL TREATMENT, DYSFUNCTION, PREVALENCE, SEPSIS, PLATELET COUNT, INTENSIVE-CARE-UNIT
journal title
HEART & LUNG
Heart Lung
volume
39
issue
1
pages
21 - 26
Web of Science type
Article
Web of Science id
000279415200004
JCR category
NURSING
JCR impact factor
1.508 (2010)
JCR rank
11/88 (2010)
JCR quartile
1 (2010)
ISSN
0147-9563
DOI
10.1016/j.hrtlng.2009.07.005
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1987118
handle
http://hdl.handle.net/1854/LU-1987118
date created
2012-01-16 13:32:23
date last changed
2016-12-19 15:45:09
@article{1987118,
  abstract     = {OBJECTIVE: Thrombocytopenia is common in intensive care units (ICUs), and is associated with a poor prognosis. An acute decrease in total platelet count is frequently observed in severe sepsis, followed by a relative increase indicating organ-failure recovery. However, few data are available describing this effect and its relationship with outcomes in specific subgroups of ICU patients. 
METHODS: A retrospective, observational cohort study was conducted to investigate the incidence and prognosis of thrombocytopenia in a cohort of critically ill patients (n = 155) with a microbiologically documented nosocomial bloodstream infection. 
RESULTS: Thrombocytopenia occurred more frequently in nonsurvivors. The ICU mortality rates increased according to severity of thrombocytopenia. Thrombocytopenia was independently associated with worse outcomes in ICU patients with nosocomial bloodstream infection. 
CONCLUSION: Determining trends in platelet counts is of additional prognostic value, compared with single measurements.},
  author       = {Vandijck, Dominique and Blot, Stijn and De Waele, Jan and Hoste, Eric and Vandewoude, Koenraad and Decruyenaere, Johan},
  issn         = {0147-9563},
  journal      = {HEART \& LUNG},
  keyword      = {ICU,ANTIMICROBIAL TREATMENT,DYSFUNCTION,PREVALENCE,SEPSIS,PLATELET COUNT,INTENSIVE-CARE-UNIT},
  language     = {eng},
  number       = {1},
  pages        = {21--26},
  title        = {Thrombocytopenia and outcome in critically ill patients with bloodstream infection},
  url          = {http://dx.doi.org/10.1016/j.hrtlng.2009.07.005},
  volume       = {39},
  year         = {2010},
}

Chicago
Vandijck, Dominique, Stijn Blot, Jan De Waele, Eric Hoste, Koenraad Vandewoude, and Johan Decruyenaere. 2010. “Thrombocytopenia and Outcome in Critically Ill Patients with Bloodstream Infection.” Heart & Lung 39 (1): 21–26.
APA
Vandijck, D., Blot, S., De Waele, J., Hoste, E., Vandewoude, K., & Decruyenaere, J. (2010). Thrombocytopenia and outcome in critically ill patients with bloodstream infection. HEART & LUNG, 39(1), 21–26.
Vancouver
1.
Vandijck D, Blot S, De Waele J, Hoste E, Vandewoude K, Decruyenaere J. Thrombocytopenia and outcome in critically ill patients with bloodstream infection. HEART & LUNG. 2010;39(1):21–6.
MLA
Vandijck, Dominique, Stijn Blot, Jan De Waele, et al. “Thrombocytopenia and Outcome in Critically Ill Patients with Bloodstream Infection.” HEART & LUNG 39.1 (2010): 21–26. Print.