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Thrombocytopenia and outcome in critically ill patients with bloodstream infection

Dominique Vandijck (UGent) , Stijn Blot (UGent) , Jan De Waele (UGent) , Eric Hoste (UGent) , Koenraad Vandewoude (UGent) and Johan Decruyenaere (UGent)
(2010) HEART & LUNG. 39(1). p.21-26
Author
Organization
Abstract
OBJECTIVE: Thrombocytopenia is common in intensive care units (ICUs), and is associated with a poor prognosis. An acute decrease in total platelet count is frequently observed in severe sepsis, followed by a relative increase indicating organ-failure recovery. However, few data are available describing this effect and its relationship with outcomes in specific subgroups of ICU patients. METHODS: A retrospective, observational cohort study was conducted to investigate the incidence and prognosis of thrombocytopenia in a cohort of critically ill patients (n = 155) with a microbiologically documented nosocomial bloodstream infection. RESULTS: Thrombocytopenia occurred more frequently in nonsurvivors. The ICU mortality rates increased according to severity of thrombocytopenia. Thrombocytopenia was independently associated with worse outcomes in ICU patients with nosocomial bloodstream infection. CONCLUSION: Determining trends in platelet counts is of additional prognostic value, compared with single measurements.
Keywords
ICU, ANTIMICROBIAL TREATMENT, DYSFUNCTION, PREVALENCE, SEPSIS, PLATELET COUNT, INTENSIVE-CARE-UNIT

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Chicago
Vandijck, Dominique, Stijn Blot, Jan De Waele, Eric Hoste, Koenraad Vandewoude, and Johan Decruyenaere. 2010. “Thrombocytopenia and Outcome in Critically Ill Patients with Bloodstream Infection.” Heart & Lung 39 (1): 21–26.
APA
Vandijck, D., Blot, S., De Waele, J., Hoste, E., Vandewoude, K., & Decruyenaere, J. (2010). Thrombocytopenia and outcome in critically ill patients with bloodstream infection. HEART & LUNG, 39(1), 21–26.
Vancouver
1.
Vandijck D, Blot S, De Waele J, Hoste E, Vandewoude K, Decruyenaere J. Thrombocytopenia and outcome in critically ill patients with bloodstream infection. HEART & LUNG. 2010;39(1):21–6.
MLA
Vandijck, Dominique, Stijn Blot, Jan De Waele, et al. “Thrombocytopenia and Outcome in Critically Ill Patients with Bloodstream Infection.” HEART & LUNG 39.1 (2010): 21–26. Print.
@article{1987118,
  abstract     = {OBJECTIVE: Thrombocytopenia is common in intensive care units (ICUs), and is associated with a poor prognosis. An acute decrease in total platelet count is frequently observed in severe sepsis, followed by a relative increase indicating organ-failure recovery. However, few data are available describing this effect and its relationship with outcomes in specific subgroups of ICU patients. 
METHODS: A retrospective, observational cohort study was conducted to investigate the incidence and prognosis of thrombocytopenia in a cohort of critically ill patients (n = 155) with a microbiologically documented nosocomial bloodstream infection. 
RESULTS: Thrombocytopenia occurred more frequently in nonsurvivors. The ICU mortality rates increased according to severity of thrombocytopenia. Thrombocytopenia was independently associated with worse outcomes in ICU patients with nosocomial bloodstream infection. 
CONCLUSION: Determining trends in platelet counts is of additional prognostic value, compared with single measurements.},
  author       = {Vandijck, Dominique and Blot, Stijn and De Waele, Jan and Hoste, Eric and Vandewoude, Koenraad and Decruyenaere, Johan},
  issn         = {0147-9563},
  journal      = {HEART \& LUNG},
  keyword      = {ICU,ANTIMICROBIAL TREATMENT,DYSFUNCTION,PREVALENCE,SEPSIS,PLATELET COUNT,INTENSIVE-CARE-UNIT},
  language     = {eng},
  number       = {1},
  pages        = {21--26},
  title        = {Thrombocytopenia and outcome in critically ill patients with bloodstream infection},
  url          = {http://dx.doi.org/10.1016/j.hrtlng.2009.07.005},
  volume       = {39},
  year         = {2010},
}

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