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Determination of lead by flow-injection inductively coupled plasma mass spectrometry comparing several calibration techniques

Jan Goossens (UGent), Luc Moens (UGent) and Richard Dams
(1994) ANALYTICA CHIMICA ACTA. 293(1-2). p.171-181
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Abstract
In this paper we have evaluated the coupling of a modular flow-injection system to an inductively coupled plasma mass spectrometer for lead determinations by direct analysis of wines and urine samples. The flow-injection system used allows an on-line sample dilution and an on-line addition of internal standard and calibrant solution. It was found that particular attention should be paid to the adjustment of the nebulizer gas flow rate in order to obtain maximum sensitivity and precision. In this way and for the experimental set-up described, R.S.D. values less than or equal to 1% on the Pb-208(+) signal for 5 consecutive injections could readily be achieved. The relative merits of external calibration, standard additions and isotope dilution for the calibration of the transient lead signals were compared. It appeared that from the viewpoint of accuracy, precision and flexibility, the standard additions method is the most preferable procedure. Further, it was found that the precision of isotope ratio determinations is degraded in comparison to continuous nebulization. However, matrix-induced mass fractionation on the lead isotope ratios as observed for the continuous nebulization of an aqueous ethanolic (wine) matrix did not occur in flow-injection analysis. The quantitation of lead by direct analysis of undiluted wine and urine samples using this flow-injection method in combination with standard additions calibration resulted in very accurate results (compared to certified and reference values). Excellent relative standard deviations (for 5 consecutive determinations) were obtained ranging from 1% (50 mu g l(-1) Pb in white wine) to 5% (3.6 mu g l(-1) Pb in urine).
Keywords
INDUCTIVELY COUPLED PLASMA MS, FLOW INJECTION, LEAD, URINE, WINE

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Chicago
Goossens, Jan, Luc Moens, and Richard Dams. 1994. “Determination of Lead by Flow-injection Inductively Coupled Plasma Mass Spectrometry Comparing Several Calibration Techniques.” Analytica Chimica Acta 293 (1-2): 171–181.
APA
Goossens, Jan, Moens, L., & Dams, R. (1994). Determination of lead by flow-injection inductively coupled plasma mass spectrometry comparing several calibration techniques. ANALYTICA CHIMICA ACTA, 293(1-2), 171–181.
Vancouver
1.
Goossens J, Moens L, Dams R. Determination of lead by flow-injection inductively coupled plasma mass spectrometry comparing several calibration techniques. ANALYTICA CHIMICA ACTA. 1994;293(1-2):171–81.
MLA
Goossens, Jan, Luc Moens, and Richard Dams. “Determination of Lead by Flow-injection Inductively Coupled Plasma Mass Spectrometry Comparing Several Calibration Techniques.” ANALYTICA CHIMICA ACTA 293.1-2 (1994): 171–181. Print.
@article{198692,
  abstract     = {In this paper we have evaluated the coupling of a modular flow-injection system to an inductively coupled plasma mass spectrometer for lead determinations by direct analysis of wines and urine samples. The flow-injection system used allows an on-line sample dilution and an on-line addition of internal standard and calibrant solution. It was found that particular attention should be paid to the adjustment of the nebulizer gas flow rate in order to obtain maximum sensitivity and precision. In this way and for the experimental set-up described, R.S.D. values less than or equal to 1\% on the Pb-208(+) signal for 5 consecutive injections could readily be achieved. The relative merits of external calibration, standard additions and isotope dilution for the calibration of the transient lead signals were compared. It appeared that from the viewpoint of accuracy, precision and flexibility, the standard additions method is the most preferable procedure. Further, it was found that the precision of isotope ratio determinations is degraded in comparison to continuous nebulization. However, matrix-induced mass fractionation on the lead isotope ratios as observed for the continuous nebulization of an aqueous ethanolic (wine) matrix did not occur in flow-injection analysis. The quantitation of lead by direct analysis of undiluted wine and urine samples using this flow-injection method in combination with standard additions calibration resulted in very accurate results (compared to certified and reference values). Excellent relative standard deviations (for 5 consecutive determinations) were obtained ranging from 1\% (50 mu g l(-1) Pb in white wine) to 5\% (3.6 mu g l(-1) Pb in urine).},
  author       = {Goossens, Jan and Moens, Luc and Dams, Richard},
  issn         = {0003-2670},
  journal      = {ANALYTICA CHIMICA ACTA},
  keyword      = {INDUCTIVELY COUPLED PLASMA MS,FLOW INJECTION,LEAD,URINE,WINE},
  language     = {eng},
  number       = {1-2},
  pages        = {171--181},
  title        = {Determination of lead by flow-injection inductively coupled plasma mass spectrometry comparing several calibration techniques},
  url          = {http://dx.doi.org/10.1016/0003-2670(94)00089-1},
  volume       = {293},
  year         = {1994},
}

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