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A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy

Kristl Vonck (UGent) , Mathieu Sprengers (UGent) , Evelien Carrette (UGent) , Marijke Miatton (UGent) , Alfred Meurs (UGent) , Veerle De Herdt (UGent) , Eric Achten (UGent) , Evert Thiery, Robrecht Raedt (UGent) , Dirk Van Roost (UGent) , et al.
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Abstract
In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Since 2001, 11 patients (8M) with refractory MTL epilepsy underwent MTL DBS. When unilateral DBS failed to decrease seizures by > 90%, a switch to bilateral MTL DBS was proposed. After a mean follow-up of 8.5 years (range: 67-120 months), 6/11 patients had a >= 90% seizure frequency reduction with 3/6 seizure-free for > 3 years; three patients had a 40%-70% reduction and two had a < 30% reduction. In 3/5 patients switching to bilateral DBS further improved outcome. Uni-or bilateral MTL DBS did not affect neuropsychological functioning. This open study with an extended long-term follow-up demonstrates maintained efficacy of DBS for MTL epilepsy. In more than half of the patients, a seizure frequency reduction of at least 90% was reached. Bilateral MTL DBS may herald superior efficacy in unilateral MTL epilepsy.
Keywords
refractory epilepsy, Neurostimulation, deep brain stimulation, medial temporal lobe, INTRACTABLE PARTIAL EPILEPSY, HIPPOCAMPAL ELECTRICAL-STIMULATION, TERM-FOLLOW-UP, FUNCTIONAL CONNECTIONS, SEIZURE CONTROL, INTRACRANIAL ELECTRODES, CEREBELLAR STIMULATION, BILATERAL REDUCTIONS, ANTERIOR NUCLEUS, THALAMIC NUCLEI

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Chicago
Vonck, Kristl, Mathieu Sprengers, Evelien Carrette, Marijke Miatton, Alfred Meurs, Veerle De Herdt, Eric Achten, et al. 2013. “A Decade of Experience with Deep Brain Stimulation for Patients with Refractory Medial Temporal Lobe Epilepsy.” International Journal of Neural Systems 23 (1).
APA
Vonck, K., Sprengers, M., Carrette, E., Miatton, M., Meurs, A., De Herdt, V., Achten, E., et al. (2013). A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 23(1).
Vancouver
1.
Vonck K, Sprengers M, Carrette E, Miatton M, Meurs A, De Herdt V, et al. A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2013;23(1).
MLA
Vonck, Kristl, Mathieu Sprengers, Evelien Carrette, et al. “A Decade of Experience with Deep Brain Stimulation for Patients with Refractory Medial Temporal Lobe Epilepsy.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 23.1 (2013): n. pag. Print.
@article{1985162,
  abstract     = {In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Since 2001, 11 patients (8M) with refractory MTL epilepsy underwent MTL DBS. When unilateral DBS failed to decrease seizures by {\textrangle} 90\%, a switch to bilateral MTL DBS was proposed. After a mean follow-up of 8.5 years (range: 67-120 months), 6/11 patients had a {\textrangle}= 90\% seizure frequency reduction with 3/6 seizure-free for {\textrangle} 3 years; three patients had a 40\%-70\% reduction and two had a {\textlangle} 30\% reduction. In 3/5 patients switching to bilateral DBS further improved outcome. Uni-or bilateral MTL DBS did not affect neuropsychological functioning. This open study with an extended long-term follow-up demonstrates maintained efficacy of DBS for MTL epilepsy. In more than half of the patients, a seizure frequency reduction of at least 90\% was reached. Bilateral MTL DBS may herald superior efficacy in unilateral MTL epilepsy.},
  articleno    = {1250034},
  author       = {Vonck, Kristl and Sprengers, Mathieu and Carrette, Evelien and Miatton, Marijke and Meurs, Alfred and De Herdt, Veerle and Achten, Eric and Thiery, Evert and Raedt, Robrecht and Van Roost, Dirk and Boon, Paul},
  issn         = {0129-0657},
  journal      = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
  keyword      = {refractory epilepsy,Neurostimulation,deep brain stimulation,medial temporal lobe,INTRACTABLE PARTIAL EPILEPSY,HIPPOCAMPAL ELECTRICAL-STIMULATION,TERM-FOLLOW-UP,FUNCTIONAL CONNECTIONS,SEIZURE CONTROL,INTRACRANIAL ELECTRODES,CEREBELLAR STIMULATION,BILATERAL REDUCTIONS,ANTERIOR NUCLEUS,THALAMIC NUCLEI},
  language     = {eng},
  number       = {1},
  pages        = {13},
  title        = {A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy},
  url          = {http://dx.doi.org/10.1142/S0129065712500347},
  volume       = {23},
  year         = {2013},
}

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