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A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy

Kristl Vonck UGent, Mathieu Sprengers UGent, EVELIEN CARRETTE UGent, MARIJKE MIATTON UGent, Alfred Meurs UGent, Veerle De Herdt UGent, Eric Achten UGent, Evert Thiery, Robrecht Raedt UGent and Dirk Van Roost UGent, et al. (2013) INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 23(1).
abstract
In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Since 2001, 11 patients (8M) with refractory MTL epilepsy underwent MTL DBS. When unilateral DBS failed to decrease seizures by > 90%, a switch to bilateral MTL DBS was proposed. After a mean follow-up of 8.5 years (range: 67-120 months), 6/11 patients had a >= 90% seizure frequency reduction with 3/6 seizure-free for > 3 years; three patients had a 40%-70% reduction and two had a < 30% reduction. In 3/5 patients switching to bilateral DBS further improved outcome. Uni-or bilateral MTL DBS did not affect neuropsychological functioning. This open study with an extended long-term follow-up demonstrates maintained efficacy of DBS for MTL epilepsy. In more than half of the patients, a seizure frequency reduction of at least 90% was reached. Bilateral MTL DBS may herald superior efficacy in unilateral MTL epilepsy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
refractory epilepsy, Neurostimulation, deep brain stimulation, medial temporal lobe, INTRACTABLE PARTIAL EPILEPSY, HIPPOCAMPAL ELECTRICAL-STIMULATION, TERM-FOLLOW-UP, FUNCTIONAL CONNECTIONS, SEIZURE CONTROL, INTRACRANIAL ELECTRODES, CEREBELLAR STIMULATION, BILATERAL REDUCTIONS, ANTERIOR NUCLEUS, THALAMIC NUCLEI
journal title
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
Int. J. Neural Syst.
volume
23
issue
1
article_number
1250034
pages
13 pages
Web of Science type
Article
Web of Science id
000316807400007
JCR category
COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE
JCR impact factor
6.056 (2013)
JCR rank
3/121 (2013)
JCR quartile
1 (2013)
ISSN
0129-0657
DOI
10.1142/S0129065712500347
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1985162
handle
http://hdl.handle.net/1854/LU-1985162
date created
2012-01-12 16:43:07
date last changed
2015-04-01 10:35:36
@article{1985162,
  abstract     = {In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated with deep brain stimulation (DBS). Since 2001, 11 patients (8M) with refractory MTL epilepsy underwent MTL DBS. When unilateral DBS failed to decrease seizures by {\textrangle} 90\%, a switch to bilateral MTL DBS was proposed. After a mean follow-up of 8.5 years (range: 67-120 months), 6/11 patients had a {\textrangle}= 90\% seizure frequency reduction with 3/6 seizure-free for {\textrangle} 3 years; three patients had a 40\%-70\% reduction and two had a {\textlangle} 30\% reduction. In 3/5 patients switching to bilateral DBS further improved outcome. Uni-or bilateral MTL DBS did not affect neuropsychological functioning. This open study with an extended long-term follow-up demonstrates maintained efficacy of DBS for MTL epilepsy. In more than half of the patients, a seizure frequency reduction of at least 90\% was reached. Bilateral MTL DBS may herald superior efficacy in unilateral MTL epilepsy.},
  articleno    = {1250034},
  author       = {Vonck, Kristl and Sprengers, Mathieu and CARRETTE, EVELIEN and MIATTON, MARIJKE and Meurs, Alfred and De Herdt, Veerle and Achten, Eric and Thiery, Evert and Raedt, Robrecht and Van Roost, Dirk and Boon, Paul},
  issn         = {0129-0657},
  journal      = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
  keyword      = {refractory epilepsy,Neurostimulation,deep brain stimulation,medial temporal lobe,INTRACTABLE PARTIAL EPILEPSY,HIPPOCAMPAL ELECTRICAL-STIMULATION,TERM-FOLLOW-UP,FUNCTIONAL CONNECTIONS,SEIZURE CONTROL,INTRACRANIAL ELECTRODES,CEREBELLAR STIMULATION,BILATERAL REDUCTIONS,ANTERIOR NUCLEUS,THALAMIC NUCLEI},
  language     = {eng},
  number       = {1},
  pages        = {13},
  title        = {A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy},
  url          = {http://dx.doi.org/10.1142/S0129065712500347},
  volume       = {23},
  year         = {2013},
}

Chicago
Vonck, Kristl, Mathieu Sprengers, EVELIEN CARRETTE, MARIJKE MIATTON, Alfred Meurs, Veerle De Herdt, Eric Achten, et al. 2013. “A Decade of Experience with Deep Brain Stimulation for Patients with Refractory Medial Temporal Lobe Epilepsy.” International Journal of Neural Systems 23 (1).
APA
Vonck, K., Sprengers, M., CARRETTE, E., MIATTON, M., Meurs, A., De Herdt, V., Achten, E., et al. (2013). A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 23(1).
Vancouver
1.
Vonck K, Sprengers M, CARRETTE E, MIATTON M, Meurs A, De Herdt V, et al. A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2013;23(1).
MLA
Vonck, Kristl, Mathieu Sprengers, EVELIEN CARRETTE, et al. “A Decade of Experience with Deep Brain Stimulation for Patients with Refractory Medial Temporal Lobe Epilepsy.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 23.1 (2013): n. pag. Print.