@article{1985148,
  abstract     = {{Invariant natural killer T (iNKT) cells are an innate T-cell lineage known to recognize a range of endogenously derived and exogenously derived glycolipid antigens. Advances in our understanding of this T-cell subset have enabled researchers to investigate the immunomodulatory activity of iNKT cell ligands in experimental models of diseases such as cancer, allergy and chronic inflammatory joint disease. To a large extent, the ability of iNKT cells to regulate such disease models has been ascribed to their capacity to promote a polarized cytokine environment, which is understood to skew adaptive immune responses. In this Review, we discuss the current understanding of how iNKT-cell polarization is regulated and relate this basic theory to the proposed role for iNKT cells in models of rheumatologic disease.}},
  author       = {{Drennan, Michael and ASPESLAGH, SANDRINE and Elewaut, Dirk}},
  issn         = {{1759-4790}},
  journal      = {{NATURE REVIEWS RHEUMATOLOGY}},
  keywords     = {{INNATE IMMUNE-RESPONSE,TOLL-LIKE RECEPTORS,COLLAGEN-INDUCED ARTHRITIS,LIGAND ALPHA-GALACTOSYLCERAMIDE,INITIATE CONTACT SENSITIVITY,V-ALPHA-14 NKT CELLS,CUTTING EDGE,DENDRITIC CELLS,SYSTEMIC-LUPUS-ERYTHEMATOSUS,MRL-LPR/LPR MICE}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{90--98}},
  title        = {{Invariant natural killer T cells in rheumatic disease : a joint dilemma}},
  url          = {{http://doi.org/10.1038/nrrheum.2009.261}},
  volume       = {{6}},
  year         = {{2010}},
}

Altmetric

View in Altmetric

Web of Science

Times cited: