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Invariant natural killer T cells in rheumatic disease : a joint dilemma

Michael Drennan (UGent) , SANDRINE ASPESLAGH (UGent) and Dirk Elewaut (UGent)
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Abstract
Invariant natural killer T (iNKT) cells are an innate T-cell lineage known to recognize a range of endogenously derived and exogenously derived glycolipid antigens. Advances in our understanding of this T-cell subset have enabled researchers to investigate the immunomodulatory activity of iNKT cell ligands in experimental models of diseases such as cancer, allergy and chronic inflammatory joint disease. To a large extent, the ability of iNKT cells to regulate such disease models has been ascribed to their capacity to promote a polarized cytokine environment, which is understood to skew adaptive immune responses. In this Review, we discuss the current understanding of how iNKT-cell polarization is regulated and relate this basic theory to the proposed role for iNKT cells in models of rheumatologic disease.
Keywords
INNATE IMMUNE-RESPONSE, TOLL-LIKE RECEPTORS, COLLAGEN-INDUCED ARTHRITIS, LIGAND ALPHA-GALACTOSYLCERAMIDE, INITIATE CONTACT SENSITIVITY, V-ALPHA-14 NKT CELLS, CUTTING EDGE, DENDRITIC CELLS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, MRL-LPR/LPR MICE

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Citation

Please use this url to cite or link to this publication:

Chicago
Drennan, Michael, SANDRINE ASPESLAGH, and Dirk Elewaut. 2010. “Invariant Natural Killer T Cells in Rheumatic Disease : a Joint Dilemma.” Nature Reviews Rheumatology 6 (2): 90–98.
APA
Drennan, M., ASPESLAGH, S., & Elewaut, D. (2010). Invariant natural killer T cells in rheumatic disease : a joint dilemma. NATURE REVIEWS RHEUMATOLOGY, 6(2), 90–98.
Vancouver
1.
Drennan M, ASPESLAGH S, Elewaut D. Invariant natural killer T cells in rheumatic disease : a joint dilemma. NATURE REVIEWS RHEUMATOLOGY. 2010;6(2):90–8.
MLA
Drennan, Michael, SANDRINE ASPESLAGH, and Dirk Elewaut. “Invariant Natural Killer T Cells in Rheumatic Disease : a Joint Dilemma.” NATURE REVIEWS RHEUMATOLOGY 6.2 (2010): 90–98. Print.
@article{1985148,
  abstract     = {Invariant natural killer T (iNKT) cells are an innate T-cell lineage known to recognize a range of endogenously derived and exogenously derived glycolipid antigens. Advances in our understanding of this T-cell subset have enabled researchers to investigate the immunomodulatory activity of iNKT cell ligands in experimental models of diseases such as cancer, allergy and chronic inflammatory joint disease. To a large extent, the ability of iNKT cells to regulate such disease models has been ascribed to their capacity to promote a polarized cytokine environment, which is understood to skew adaptive immune responses. In this Review, we discuss the current understanding of how iNKT-cell polarization is regulated and relate this basic theory to the proposed role for iNKT cells in models of rheumatologic disease.},
  author       = {Drennan, Michael and ASPESLAGH, SANDRINE and Elewaut, Dirk},
  issn         = {1759-4790},
  journal      = {NATURE REVIEWS RHEUMATOLOGY},
  keyword      = {INNATE IMMUNE-RESPONSE,TOLL-LIKE RECEPTORS,COLLAGEN-INDUCED ARTHRITIS,LIGAND ALPHA-GALACTOSYLCERAMIDE,INITIATE CONTACT SENSITIVITY,V-ALPHA-14 NKT CELLS,CUTTING EDGE,DENDRITIC CELLS,SYSTEMIC-LUPUS-ERYTHEMATOSUS,MRL-LPR/LPR MICE},
  language     = {eng},
  number       = {2},
  pages        = {90--98},
  title        = {Invariant natural killer T cells in rheumatic disease : a joint dilemma},
  url          = {http://dx.doi.org/10.1038/nrrheum.2009.261},
  volume       = {6},
  year         = {2010},
}

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