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Invariant natural killer T cells in rheumatic disease : a joint dilemma

Michael Drennan, SANDRINE ASPESLAGH and Dirk Elewaut UGent (2010) NATURE REVIEWS RHEUMATOLOGY. 6(2). p.90-98
abstract
Invariant natural killer T (iNKT) cells are an innate T-cell lineage known to recognize a range of endogenously derived and exogenously derived glycolipid antigens. Advances in our understanding of this T-cell subset have enabled researchers to investigate the immunomodulatory activity of iNKT cell ligands in experimental models of diseases such as cancer, allergy and chronic inflammatory joint disease. To a large extent, the ability of iNKT cells to regulate such disease models has been ascribed to their capacity to promote a polarized cytokine environment, which is understood to skew adaptive immune responses. In this Review, we discuss the current understanding of how iNKT-cell polarization is regulated and relate this basic theory to the proposed role for iNKT cells in models of rheumatologic disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
INNATE IMMUNE-RESPONSE, TOLL-LIKE RECEPTORS, COLLAGEN-INDUCED ARTHRITIS, LIGAND ALPHA-GALACTOSYLCERAMIDE, INITIATE CONTACT SENSITIVITY, V-ALPHA-14 NKT CELLS, CUTTING EDGE, DENDRITIC CELLS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, MRL-LPR/LPR MICE
journal title
NATURE REVIEWS RHEUMATOLOGY
Nat. Rev. Rheumatol.
volume
6
issue
2
pages
90 - 98
Web of Science type
Review
Web of Science id
000274232700008
JCR category
RHEUMATOLOGY
JCR impact factor
6.448 (2010)
JCR rank
4/29 (2010)
JCR quartile
1 (2010)
ISSN
1759-4790
DOI
10.1038/nrrheum.2009.261
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1985148
handle
http://hdl.handle.net/1854/LU-1985148
date created
2012-01-12 16:30:16
date last changed
2017-06-21 08:15:55
@article{1985148,
  abstract     = {Invariant natural killer T (iNKT) cells are an innate T-cell lineage known to recognize a range of endogenously derived and exogenously derived glycolipid antigens. Advances in our understanding of this T-cell subset have enabled researchers to investigate the immunomodulatory activity of iNKT cell ligands in experimental models of diseases such as cancer, allergy and chronic inflammatory joint disease. To a large extent, the ability of iNKT cells to regulate such disease models has been ascribed to their capacity to promote a polarized cytokine environment, which is understood to skew adaptive immune responses. In this Review, we discuss the current understanding of how iNKT-cell polarization is regulated and relate this basic theory to the proposed role for iNKT cells in models of rheumatologic disease.},
  author       = {Drennan, Michael and ASPESLAGH, SANDRINE and Elewaut, Dirk},
  issn         = {1759-4790},
  journal      = {NATURE REVIEWS RHEUMATOLOGY},
  keyword      = {INNATE IMMUNE-RESPONSE,TOLL-LIKE RECEPTORS,COLLAGEN-INDUCED ARTHRITIS,LIGAND ALPHA-GALACTOSYLCERAMIDE,INITIATE CONTACT SENSITIVITY,V-ALPHA-14 NKT CELLS,CUTTING EDGE,DENDRITIC CELLS,SYSTEMIC-LUPUS-ERYTHEMATOSUS,MRL-LPR/LPR MICE},
  language     = {eng},
  number       = {2},
  pages        = {90--98},
  title        = {Invariant natural killer T cells in rheumatic disease : a joint dilemma},
  url          = {http://dx.doi.org/10.1038/nrrheum.2009.261},
  volume       = {6},
  year         = {2010},
}

Chicago
Drennan, Michael, SANDRINE ASPESLAGH, and Dirk Elewaut. 2010. “Invariant Natural Killer T Cells in Rheumatic Disease : a Joint Dilemma.” Nature Reviews Rheumatology 6 (2): 90–98.
APA
Drennan, M., ASPESLAGH, S., & Elewaut, D. (2010). Invariant natural killer T cells in rheumatic disease : a joint dilemma. NATURE REVIEWS RHEUMATOLOGY, 6(2), 90–98.
Vancouver
1.
Drennan M, ASPESLAGH S, Elewaut D. Invariant natural killer T cells in rheumatic disease : a joint dilemma. NATURE REVIEWS RHEUMATOLOGY. 2010;6(2):90–8.
MLA
Drennan, Michael, SANDRINE ASPESLAGH, and Dirk Elewaut. “Invariant Natural Killer T Cells in Rheumatic Disease : a Joint Dilemma.” NATURE REVIEWS RHEUMATOLOGY 6.2 (2010): 90–98. Print.