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First order correction for T*2-relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

Dieter De Naeyer UGent, Isabelle Debergh UGent, Yves De Deene UGent, Wim Ceelen UGent, Patrick Segers UGent and Pascal Verdonck UGent (2011) JOURNAL OF MAGNETIC RESONANCE IMAGING. 34(3). p.710-715
abstract
Purpose: To investigate the accuracy of a method neglecting T*(2)-relaxation, for the conversion of spoiled gradient echo pulse sequence signal intensity to contrast agent (CA) concentration, in dynamic contrast enhanced MRI studies. In addition a new closed form conversion expression is proposed that accounts for a first order approximation of T*(2)-relaxation. Materials and Methods: The accuracy of both conversion methods is compared theoretically by means of simulations for four pulse sequences from literature. Both methods are tested in vivo against the numerical conversion method for measuring the arterial input function in mice. Results: Simulations show that the T*(2)-neglecting method underestimates typical tissue CA concentrations (0 mM to 2 mM) up to 6%, while the errors for arterial concentrations (0 mM to 10 mM) range up to 43%. The results from our first order method are numerically indistinguishable from the simulation input values in tumor tissue, while for arterial concentrations the error is reduced up to a factor 10. In vivo, peak Gd-DOTA concentration is underestimated up to 14% with the T*(2-)neglecting method and up to 0.9% with our first order method. Conclusion: Our conversion method reduces the underestimation of CA concentration severely in a broad physiological concentration range and is easy to perform in any clinical setting.
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author
organization
alternative title
First order correction for T*(2)-relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity
year
type
journalArticle (original)
publication status
published
subject
keyword
contrast agent concentration, T2*-relaxation, SPGRE, DCE-MRI, ARTERIAL INPUT FUNCTION, ENHANCED MRI, RHEUMATOID-ARTHRITIS, FLIP ANGLES, PARAMETERS, REPRODUCIBILITY, QUANTIFICATION, PERMEABILITY, UNCERTAINTY, PERFUSION
journal title
JOURNAL OF MAGNETIC RESONANCE IMAGING
J. Magn. Reson. Imaging
volume
34
issue
3
pages
710 - 715
Web of Science type
Article
Web of Science id
000294442900029
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.698 (2011)
JCR rank
34/116 (2011)
JCR quartile
2 (2011)
ISSN
1053-1807
DOI
10.1002/jmri.22681
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1984593
handle
http://hdl.handle.net/1854/LU-1984593
date created
2012-01-12 13:52:09
date last changed
2012-01-17 11:52:06
@article{1984593,
  abstract     = {Purpose: To investigate the accuracy of a method neglecting T*(2)-relaxation, for the conversion of spoiled gradient echo pulse sequence signal intensity to contrast agent (CA) concentration, in dynamic contrast enhanced MRI studies. In addition a new closed form conversion expression is proposed that accounts for a first order approximation of T*(2)-relaxation. 
Materials and Methods: The accuracy of both conversion methods is compared theoretically by means of simulations for four pulse sequences from literature. Both methods are tested in vivo against the numerical conversion method for measuring the arterial input function in mice. 
Results: Simulations show that the T*(2)-neglecting method underestimates typical tissue CA concentrations (0 mM to 2 mM) up to 6\%, while the errors for arterial concentrations (0 mM to 10 mM) range up to 43\%. The results from our first order method are numerically indistinguishable from the simulation input values in tumor tissue, while for arterial concentrations the error is reduced up to a factor 10. In vivo, peak Gd-DOTA concentration is underestimated up to 14\% with the T*(2-)neglecting method and up to 0.9\% with our first order method. 
Conclusion: Our conversion method reduces the underestimation of CA concentration severely in a broad physiological concentration range and is easy to perform in any clinical setting.},
  author       = {De Naeyer, Dieter and Debergh, Isabelle and De Deene, Yves and Ceelen, Wim and Segers, Patrick and Verdonck, Pascal},
  issn         = {1053-1807},
  journal      = {JOURNAL OF MAGNETIC RESONANCE IMAGING},
  keyword      = {contrast agent concentration,T2*-relaxation,SPGRE,DCE-MRI,ARTERIAL INPUT FUNCTION,ENHANCED MRI,RHEUMATOID-ARTHRITIS,FLIP ANGLES,PARAMETERS,REPRODUCIBILITY,QUANTIFICATION,PERMEABILITY,UNCERTAINTY,PERFUSION},
  language     = {eng},
  number       = {3},
  pages        = {710--715},
  title        = {First order correction for T*2-relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity},
  url          = {http://dx.doi.org/10.1002/jmri.22681},
  volume       = {34},
  year         = {2011},
}

Chicago
De Naeyer, Dieter, Isabelle Debergh, Yves De Deene, Wim Ceelen, Patrick Segers, and Pascal Verdonck. 2011. “First Order Correction for T*2-relaxation in Determining Contrast Agent Concentration from Spoiled Gradient Echo Pulse Sequence Signal Intensity.” Journal of Magnetic Resonance Imaging 34 (3): 710–715.
APA
De Naeyer, D., Debergh, I., De Deene, Y., Ceelen, W., Segers, P., & Verdonck, P. (2011). First order correction for T*2-relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity. JOURNAL OF MAGNETIC RESONANCE IMAGING, 34(3), 710–715.
Vancouver
1.
De Naeyer D, Debergh I, De Deene Y, Ceelen W, Segers P, Verdonck P. First order correction for T*2-relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity. JOURNAL OF MAGNETIC RESONANCE IMAGING. 2011;34(3):710–5.
MLA
De Naeyer, Dieter, Isabelle Debergh, Yves De Deene, et al. “First Order Correction for T*2-relaxation in Determining Contrast Agent Concentration from Spoiled Gradient Echo Pulse Sequence Signal Intensity.” JOURNAL OF MAGNETIC RESONANCE IMAGING 34.3 (2011): 710–715. Print.