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Histone modifications in herpesvirus infections

Nina Van Opdenbosch UGent, Herman Favoreel UGent and Gerlinde Van de Walle UGent (2012) BIOLOGY OF THE CELL. 104(3). p.139-164
abstract
In eukaryotic cells, gene expression is not only regulated by transcription factors but also by several epigenetic mechanisms including post-translational modifications of histone proteins. There are numerous histone modifications described to date and methylation, acetylation, ubiquitination and phosphorylation are amongst the best studied. In parallel, certain viruses interact with the very same regulatory mechanisms, hereby manipulating the normal epigenetic landscape of the host cell, to fit their own replication needs. This review concentrates on herpesviruses specifically and how they interfere with the histone-modifying enzymes to regulate their replication cycles. Herpesviruses vary greatly with respect to the cell types they infect and the clinical diseases they cause, yet they share various common features including their capacity to encode viral proteins which affect and interfere with the normal functions of histone-modifying enzymes. Studying the epigenetic manipulation/dysregulation of herpesvirus-host interactions not only generates novel insights into the pathogenesis of these viruses but may also have important therapeutic implications.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Histone acetylation, Herpesvirus, Histone methylation, Latency, Lytic infection, EPSTEIN-BARR-VIRUS, SARCOMA-ASSOCIATED HERPESVIRUS, CREB-BINDING-PROTEIN, EARLY GENE-EXPRESSION, RBP-J-KAPPA, TRANSCRIPTIONAL COACTIVATOR HCF-1, UBIQUITIN-SPECIFIC PROTEASE, IMMEDIATE-EARLY PROMOTERS, NOTCH SIGNALING PATHWAY, DNA-DAMAGE RESPONSE
journal title
BIOLOGY OF THE CELL
Biol. Cell
volume
104
issue
3
pages
139 - 164
Web of Science type
Review
Web of Science id
000304653400003
JCR category
CELL BIOLOGY
JCR impact factor
3.488 (2012)
JCR rank
82/181 (2012)
JCR quartile
2 (2012)
ISSN
0248-4900
DOI
10.1111/boc.201100067
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1984277
handle
http://hdl.handle.net/1854/LU-1984277
date created
2012-01-12 10:55:04
date last changed
2012-09-11 09:54:58
@article{1984277,
  abstract     = {In eukaryotic cells, gene expression is not only regulated by transcription factors but also by several epigenetic mechanisms including post-translational modifications of histone proteins. There are numerous histone modifications described to date and methylation, acetylation, ubiquitination and phosphorylation are amongst the best studied. In parallel, certain viruses interact with the very same regulatory mechanisms, hereby manipulating the normal epigenetic landscape of the host cell, to fit their own replication needs. This review concentrates on herpesviruses specifically and how they interfere with the histone-modifying enzymes to regulate their replication cycles. Herpesviruses vary greatly with respect to the cell types they infect and the clinical diseases they cause, yet they share various common features including their capacity to encode viral proteins which affect and interfere with the normal functions of histone-modifying enzymes. Studying the epigenetic manipulation/dysregulation of herpesvirus-host interactions not only generates novel insights into the pathogenesis of these viruses but may also have important therapeutic implications.},
  author       = {Van Opdenbosch, Nina and Favoreel, Herman and Van de Walle, Gerlinde},
  issn         = {0248-4900},
  journal      = {BIOLOGY OF THE CELL},
  keyword      = {Histone acetylation,Herpesvirus,Histone methylation,Latency,Lytic infection,EPSTEIN-BARR-VIRUS,SARCOMA-ASSOCIATED HERPESVIRUS,CREB-BINDING-PROTEIN,EARLY GENE-EXPRESSION,RBP-J-KAPPA,TRANSCRIPTIONAL COACTIVATOR HCF-1,UBIQUITIN-SPECIFIC PROTEASE,IMMEDIATE-EARLY PROMOTERS,NOTCH SIGNALING PATHWAY,DNA-DAMAGE RESPONSE},
  language     = {eng},
  number       = {3},
  pages        = {139--164},
  title        = {Histone modifications in herpesvirus infections},
  url          = {http://dx.doi.org/10.1111/boc.201100067},
  volume       = {104},
  year         = {2012},
}

Chicago
Van Opdenbosch, Nina, Herman Favoreel, and Gerlinde Van de Walle. 2012. “Histone Modifications in Herpesvirus Infections.” Biology of the Cell 104 (3): 139–164.
APA
Van Opdenbosch, N., Favoreel, H., & Van de Walle, G. (2012). Histone modifications in herpesvirus infections. BIOLOGY OF THE CELL, 104(3), 139–164.
Vancouver
1.
Van Opdenbosch N, Favoreel H, Van de Walle G. Histone modifications in herpesvirus infections. BIOLOGY OF THE CELL. 2012;104(3):139–64.
MLA
Van Opdenbosch, Nina, Herman Favoreel, and Gerlinde Van de Walle. “Histone Modifications in Herpesvirus Infections.” BIOLOGY OF THE CELL 104.3 (2012): 139–164. Print.