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Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function

Sylvie Taveirne UGent, Veerle De Colvenaer, Tina Van Den Broeck UGent, Els Van Ammel UGent, Clare L Bennett, Tom Taghon UGent, Bart Vandekerckhove UGent, Jean Plum, Björn E Clausen, Daniel H Kaplan, et al. (2011) JOURNAL OF LEUKOCYTE BIOLOGY. 90(1). p.61-68
abstract
This study tested the hypothesis that V gamma 3 TCR-bearing T cells are influenced by LCs. V gamma 3 T cells and LCs are located in the epidermis of mice. V gamma 3 T cells represent the main T cell population in the skin epithelium and play a crucial role in maintaining the skin integrity, whereas LCs are professional APCs. Although V gamma 3 T cells and LCs form an interdigitating network in the epidermis, not much is known about their reciprocal influence and/or interdependence. We used two different LC-deficient mouse models, in which LCs are constitutively or inducibly depleted, to investigate the role of LCs in maturation, homeostasis, and function of V gamma 3 T cells. We show that V gamma 3 T cell numbers are unaltered by LC deficiency, and V gamma 3 T cells isolated from LC-deficient mice are phenotypically and upon in vitro stimulation, functionally indistinguishable from V gamma 3 T cells isolated from WT mice based on their cytotoxic potential and cytokine production. Additionally, in vivo skin-wounding experiments show no major difference in response of V gamma 3 T cells to wounding in the absence or presence of LCs. These observations indicate that V gamma 3 T cells develop and function independently of LCs
Please use this url to cite or link to this publication:
author
organization
alternative title
Langerhans cells are not required for epidermal V gamma 3 T cell homeostasis and function
year
type
journalArticle (original)
publication status
published
subject
keyword
LC deficiency, Langerin DTR mice, NATURAL-KILLER-CELLS, DENDRITIC CELLS, CONTACT HYPERSENSITIVITY, DEFICIENT MICE, BONE-MARROW, GAMMA-GENES, IN-VITRO, RECEPTOR, SKIN, EXPRESSION, Langerin DTA mice, skin
journal title
JOURNAL OF LEUKOCYTE BIOLOGY
J. Leukoc. Biol.
volume
90
issue
1
pages
61 - 68
Web of Science type
Article
Web of Science id
000292244200008
JCR category
HEMATOLOGY
JCR impact factor
4.992 (2011)
JCR rank
12/68 (2011)
JCR quartile
1 (2011)
ISSN
0741-5400
DOI
10.1189/jlb.1010581
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1984194
handle
http://hdl.handle.net/1854/LU-1984194
date created
2012-01-12 10:14:16
date last changed
2016-12-19 15:42:53
@article{1984194,
  abstract     = {This study tested the hypothesis that V gamma 3 TCR-bearing T cells are influenced by LCs. V gamma 3 T cells and LCs are located in the epidermis of mice. V gamma 3 T cells represent the main T cell population in the skin epithelium and play a crucial role in maintaining the skin integrity, whereas LCs are professional APCs. Although V gamma 3 T cells and LCs form an interdigitating network in the epidermis, not much is known about their reciprocal influence and/or interdependence. We used two different LC-deficient mouse models, in which LCs are constitutively or inducibly depleted, to investigate the role of LCs in maturation, homeostasis, and function of V gamma 3 T cells. We show that V gamma 3 T cell numbers are unaltered by LC deficiency, and V gamma 3 T cells isolated from LC-deficient mice are phenotypically and upon in vitro stimulation, functionally indistinguishable from V gamma 3 T cells isolated from WT mice based on their cytotoxic potential and cytokine production. Additionally, in vivo skin-wounding experiments show no major difference in response of V gamma 3 T cells to wounding in the absence or presence of LCs. These observations indicate that V gamma 3 T cells develop and function independently of LCs},
  author       = {Taveirne, Sylvie and De Colvenaer, Veerle and Van Den Broeck, Tina and Van Ammel, Els and Bennett, Clare L and Taghon, Tom and Vandekerckhove, Bart and Plum, Jean and Clausen, Bj{\"o}rn E and Kaplan, Daniel H and Leclercq, Georges},
  issn         = {0741-5400},
  journal      = {JOURNAL OF LEUKOCYTE BIOLOGY},
  keyword      = {LC deficiency,Langerin DTR mice,NATURAL-KILLER-CELLS,DENDRITIC CELLS,CONTACT HYPERSENSITIVITY,DEFICIENT MICE,BONE-MARROW,GAMMA-GENES,IN-VITRO,RECEPTOR,SKIN,EXPRESSION,Langerin DTA mice,skin},
  language     = {eng},
  number       = {1},
  pages        = {61--68},
  title        = {Langerhans cells are not required for epidermal V\ensuremath{\gamma}3 T cell homeostasis and function},
  url          = {http://dx.doi.org/10.1189/jlb.1010581},
  volume       = {90},
  year         = {2011},
}

Chicago
Taveirne, Sylvie, Veerle De Colvenaer, Tina Van Den Broeck, Els Van Ammel, Clare L Bennett, Tom Taghon, Bart Vandekerckhove, et al. 2011. “Langerhans Cells Are Not Required for Epidermal Vγ3 T Cell Homeostasis and Function.” Journal of Leukocyte Biology 90 (1): 61–68.
APA
Taveirne, S., De Colvenaer, V., Van Den Broeck, T., Van Ammel, E., Bennett, C. L., Taghon, T., Vandekerckhove, B., et al. (2011). Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function. JOURNAL OF LEUKOCYTE BIOLOGY, 90(1), 61–68.
Vancouver
1.
Taveirne S, De Colvenaer V, Van Den Broeck T, Van Ammel E, Bennett CL, Taghon T, et al. Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function. JOURNAL OF LEUKOCYTE BIOLOGY. 2011;90(1):61–8.
MLA
Taveirne, Sylvie, Veerle De Colvenaer, Tina Van Den Broeck, et al. “Langerhans Cells Are Not Required for Epidermal Vγ3 T Cell Homeostasis and Function.” JOURNAL OF LEUKOCYTE BIOLOGY 90.1 (2011): 61–68. Print.