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Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

Sylvie Taveirne UGent, Jessica Filtjens, Els Van Ammel UGent, Veerle De Colvenaer, Tessa Kerre UGent, Tom Taghon UGent, Bart Vandekerckhove UGent, Jean Plum, Werner Held and Georges Leclercq UGent (2011) BLOOD. 118(2). p.339-347
abstract
The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or whether they improve the responsiveness of all cell types, which express them. To address this issue, we analyzed the expression of inhibitory MHC-I receptors on intestinal intraepithelial lymphocytes (iIELs) and show that T-cell receptor (TCR)-alpha beta CD8 alpha alpha iIELs express multiple inhibitory receptors specific for MHC-I molecules, including CD94/NKG2A, Ly49A, and Ly49G2. However, the presence of MHC-I ligand for these receptors did not improve the response of iIELs to activation via the TCR. The absence of iIEL education by MHC-I receptors was not related to a lack of inhibitory function of these receptors in iIELs and a failure of these receptors to couple to the TCR. Thus, unlike NK cells, iIELs do not undergo an MHC-I-guided education process. These data suggest that education is an NK cell-specific function of inhibitory MHC-I receptors.
Please use this url to cite or link to this publication:
author
organization
alternative title
Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8 alpha alpha intestinal intraepithelial T lymphocytes
year
type
journalArticle (original)
publication status
published
subject
keyword
MOLECULES, RESPONSIVENESS, EXPRESSION, LY49 RECEPTORS, SELF-TOLERANCE, NATURAL-KILLER-CELLS, GUT, CIS, IDENTIFICATION, ENVIRONMENT
journal title
BLOOD
Blood
volume
118
issue
2
pages
339 - 347
Web of Science type
Article
Web of Science id
000292735100019
JCR category
HEMATOLOGY
JCR impact factor
9.898 (2011)
JCR rank
2/68 (2011)
JCR quartile
1 (2011)
ISSN
0006-4971
DOI
10.1182/blood-2011-01-331124
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1984182
handle
http://hdl.handle.net/1854/LU-1984182
date created
2012-01-12 10:14:08
date last changed
2016-12-19 15:42:53
@article{1984182,
  abstract     = {The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or whether they improve the responsiveness of all cell types, which express them. To address this issue, we analyzed the expression of inhibitory MHC-I receptors on intestinal intraepithelial lymphocytes (iIELs) and show that T-cell receptor (TCR)-alpha beta CD8 alpha alpha iIELs express multiple inhibitory receptors specific for MHC-I molecules, including CD94/NKG2A, Ly49A, and Ly49G2. However, the presence of MHC-I ligand for these receptors did not improve the response of iIELs to activation via the TCR. The absence of iIEL education by MHC-I receptors was not related to a lack of inhibitory function of these receptors in iIELs and a failure of these receptors to couple to the TCR. Thus, unlike NK cells, iIELs do not undergo an MHC-I-guided education process. These data suggest that education is an NK cell-specific function of inhibitory MHC-I receptors.},
  author       = {Taveirne, Sylvie and Filtjens, Jessica and Van Ammel, Els and De Colvenaer, Veerle and Kerre, Tessa and Taghon, Tom and Vandekerckhove, Bart and Plum, Jean and Held, Werner and Leclercq, Georges},
  issn         = {0006-4971},
  journal      = {BLOOD},
  keyword      = {MOLECULES,RESPONSIVENESS,EXPRESSION,LY49 RECEPTORS,SELF-TOLERANCE,NATURAL-KILLER-CELLS,GUT,CIS,IDENTIFICATION,ENVIRONMENT},
  language     = {eng},
  number       = {2},
  pages        = {339--347},
  title        = {Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8\ensuremath{\alpha}\ensuremath{\alpha} intestinal intraepithelial T lymphocytes},
  url          = {http://dx.doi.org/10.1182/blood-2011-01-331124},
  volume       = {118},
  year         = {2011},
}

Chicago
Taveirne, Sylvie, Jessica Filtjens, Els Van Ammel, Veerle De Colvenaer, Tessa Kerre, Tom Taghon, Bart Vandekerckhove, Jean Plum, Werner Held, and Georges Leclercq. 2011. “Inhibitory Receptors Specific for MHC Class I Educate Murine NK Cells but Not CD8αα Intestinal Intraepithelial T Lymphocytes.” Blood 118 (2): 339–347.
APA
Taveirne, S., Filtjens, J., Van Ammel, E., De Colvenaer, V., Kerre, T., Taghon, T., Vandekerckhove, B., et al. (2011). Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes. BLOOD, 118(2), 339–347.
Vancouver
1.
Taveirne S, Filtjens J, Van Ammel E, De Colvenaer V, Kerre T, Taghon T, et al. Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes. BLOOD. 2011;118(2):339–47.
MLA
Taveirne, Sylvie, Jessica Filtjens, Els Van Ammel, et al. “Inhibitory Receptors Specific for MHC Class I Educate Murine NK Cells but Not CD8αα Intestinal Intraepithelial T Lymphocytes.” BLOOD 118.2 (2011): 339–347. Print.