Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes
- Author
- Sylvie Taveirne (UGent) , Jessica Filtjens (UGent) , Els Van Ammel (UGent) , Veerle De Colvenaer (UGent) , Tessa Kerre (UGent) , Tom Taghon (UGent) , Bart Vandekerckhove (UGent) , Jean Plum (UGent) , Werner Held and Georges Leclercq (UGent)
- Organization
- Abstract
- The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or whether they improve the responsiveness of all cell types, which express them. To address this issue, we analyzed the expression of inhibitory MHC-I receptors on intestinal intraepithelial lymphocytes (iIELs) and show that T-cell receptor (TCR)-alpha beta CD8 alpha alpha iIELs express multiple inhibitory receptors specific for MHC-I molecules, including CD94/NKG2A, Ly49A, and Ly49G2. However, the presence of MHC-I ligand for these receptors did not improve the response of iIELs to activation via the TCR. The absence of iIEL education by MHC-I receptors was not related to a lack of inhibitory function of these receptors in iIELs and a failure of these receptors to couple to the TCR. Thus, unlike NK cells, iIELs do not undergo an MHC-I-guided education process. These data suggest that education is an NK cell-specific function of inhibitory MHC-I receptors.
- Keywords
- MOLECULES, RESPONSIVENESS, EXPRESSION, LY49 RECEPTORS, SELF-TOLERANCE, NATURAL-KILLER-CELLS, GUT, CIS, IDENTIFICATION, ENVIRONMENT
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1984182
- Chicago
- Taveirne, Sylvie, Jessica Filtjens, Els Van Ammel, Veerle De Colvenaer, Tessa Kerre, Tom Taghon, Bart Vandekerckhove, Jean Plum, Werner Held, and Georges Leclercq. 2011. “Inhibitory Receptors Specific for MHC Class I Educate Murine NK Cells but Not CD8αα Intestinal Intraepithelial T Lymphocytes.” Blood 118 (2): 339–347.
- APA
- Taveirne, S., Filtjens, J., Van Ammel, E., De Colvenaer, V., Kerre, T., Taghon, T., Vandekerckhove, B., et al. (2011). Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes. BLOOD, 118(2), 339–347.
- Vancouver
- 1.Taveirne S, Filtjens J, Van Ammel E, De Colvenaer V, Kerre T, Taghon T, et al. Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes. BLOOD. 2011;118(2):339–47.
- MLA
- Taveirne, Sylvie, Jessica Filtjens, Els Van Ammel, et al. “Inhibitory Receptors Specific for MHC Class I Educate Murine NK Cells but Not CD8αα Intestinal Intraepithelial T Lymphocytes.” BLOOD 118.2 (2011): 339–347. Print.
@article{1984182,
abstract = {The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or whether they improve the responsiveness of all cell types, which express them. To address this issue, we analyzed the expression of inhibitory MHC-I receptors on intestinal intraepithelial lymphocytes (iIELs) and show that T-cell receptor (TCR)-alpha beta CD8 alpha alpha iIELs express multiple inhibitory receptors specific for MHC-I molecules, including CD94/NKG2A, Ly49A, and Ly49G2. However, the presence of MHC-I ligand for these receptors did not improve the response of iIELs to activation via the TCR. The absence of iIEL education by MHC-I receptors was not related to a lack of inhibitory function of these receptors in iIELs and a failure of these receptors to couple to the TCR. Thus, unlike NK cells, iIELs do not undergo an MHC-I-guided education process. These data suggest that education is an NK cell-specific function of inhibitory MHC-I receptors.},
author = {Taveirne, Sylvie and Filtjens, Jessica and Van Ammel, Els and De Colvenaer, Veerle and Kerre, Tessa and Taghon, Tom and Vandekerckhove, Bart and Plum, Jean and Held, Werner and Leclercq, Georges},
issn = {0006-4971},
journal = {BLOOD},
keyword = {MOLECULES,RESPONSIVENESS,EXPRESSION,LY49 RECEPTORS,SELF-TOLERANCE,NATURAL-KILLER-CELLS,GUT,CIS,IDENTIFICATION,ENVIRONMENT},
language = {eng},
number = {2},
pages = {339--347},
title = {Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8\ensuremath{\alpha}\ensuremath{\alpha} intestinal intraepithelial T lymphocytes},
url = {http://dx.doi.org/10.1182/blood-2011-01-331124},
volume = {118},
year = {2011},
}
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