Ghent University Academic Bibliography

Advanced

Cyclic AMP: a selective modulator of NF-κB action

Sarah Gerlo UGent, Ron Kooijman, Ilse Beck UGent, Krzysztof Kolmus UGent, Anneleen Spooren UGent and Guy Haegeman UGent (2011) CELLULAR AND MOLECULAR LIFE SCIENCES. 68(23). p.3823-3841
abstract
It has been known for several decades that cyclic AMP (cAMP), a prototypical second messenger, transducing the action of a variety of G-protein-coupled receptor ligands, has potent immunosuppressive and anti-inflammatory actions. These actions have been attributed in part to the ability of cAMP-induced signals to interfere with the function of the proinflammatory transcription factor Nuclear Factor-kappaB (NF-kappa B). NF-kappa B plays a crucial role in switching on the gene expression of a plethora of inflammatory and immune mediators, and as such is one of the master regulators of the immune response and a key target for anti-inflammatory drug design. A number of fundamental molecular mechanisms, contributing to the overall inhibitory actions of cAMP on NF-kappa B function, are well established. Paradoxically, recent reports indicate that cAMP, via its main effector, the protein kinase A (PKA), also promotes NF-kappa B activity. Indeed, cAMP actions appear to be highly cell type- and context-dependent. Importantly, several novel players in the cAMP/NF-kappa B connection, which selectively direct cAMP action, have been recently identified. These findings not only open up exciting new research avenues but also reveal novel opportunities for the design of more selective, NF-kappa B-targeting, anti-inflammatory drugs.
Please use this url to cite or link to this publication:
author
organization
alternative title
Cyclic AMP : a selective modulator of NF-kappa B action
year
type
journalArticle (review)
publication status
published
subject
keyword
Nuclear Factor-kappaB (NF-kappa B), Cyclic AMP (cAMP), Inflammation, Protein kinase A (PKA), CREB, PROTEIN-KINASE-A, TUMOR-NECROSIS-FACTOR, VASOACTIVE-INTESTINAL-PEPTIDE, NITRIC-OXIDE SYNTHASE, TNF-ALPHA PRODUCTION, SMOOTH-MUSCLE-CELLS, ALVEOLAR EPITHELIAL-CELLS, ELEMENT-BINDING PROTEIN, ALCOHOLIC LIVER-DISEASE, NUCLEAR-FACTOR
journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
Cell. Mol. Life Sci.
volume
68
issue
23
pages
3823 - 3841
Web of Science type
Review
Web of Science id
000297125200004
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
6.57 (2011)
JCR rank
35/286 (2011)
JCR quartile
1 (2011)
ISSN
1420-682X
DOI
10.1007/s00018-011-0757-8
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1984024
handle
http://hdl.handle.net/1854/LU-1984024
date created
2012-01-12 09:22:50
date last changed
2013-02-27 09:09:29
@article{1984024,
  abstract     = {It has been known for several decades that cyclic AMP (cAMP), a prototypical second messenger, transducing the action of a variety of G-protein-coupled receptor ligands, has potent immunosuppressive and anti-inflammatory actions. These actions have been attributed in part to the ability of cAMP-induced signals to interfere with the function of the proinflammatory transcription factor Nuclear Factor-kappaB (NF-kappa B). NF-kappa B plays a crucial role in switching on the gene expression of a plethora of inflammatory and immune mediators, and as such is one of the master regulators of the immune response and a key target for anti-inflammatory drug design. A number of fundamental molecular mechanisms, contributing to the overall inhibitory actions of cAMP on NF-kappa B function, are well established. Paradoxically, recent reports indicate that cAMP, via its main effector, the protein kinase A (PKA), also promotes NF-kappa B activity. Indeed, cAMP actions appear to be highly cell type- and context-dependent. Importantly, several novel players in the cAMP/NF-kappa B connection, which selectively direct cAMP action, have been recently identified. These findings not only open up exciting new research avenues but also reveal novel opportunities for the design of more selective, NF-kappa B-targeting, anti-inflammatory drugs.},
  author       = {Gerlo, Sarah and Kooijman, Ron and Beck, Ilse and Kolmus, Krzysztof and Spooren, Anneleen and Haegeman, Guy},
  issn         = {1420-682X},
  journal      = {CELLULAR AND MOLECULAR LIFE SCIENCES},
  keyword      = {Nuclear Factor-kappaB (NF-kappa B),Cyclic AMP (cAMP),Inflammation,Protein kinase A (PKA),CREB,PROTEIN-KINASE-A,TUMOR-NECROSIS-FACTOR,VASOACTIVE-INTESTINAL-PEPTIDE,NITRIC-OXIDE SYNTHASE,TNF-ALPHA PRODUCTION,SMOOTH-MUSCLE-CELLS,ALVEOLAR EPITHELIAL-CELLS,ELEMENT-BINDING PROTEIN,ALCOHOLIC LIVER-DISEASE,NUCLEAR-FACTOR},
  language     = {eng},
  number       = {23},
  pages        = {3823--3841},
  title        = {Cyclic AMP: a selective modulator of NF-\ensuremath{\kappa}B action},
  url          = {http://dx.doi.org/10.1007/s00018-011-0757-8},
  volume       = {68},
  year         = {2011},
}

Chicago
Gerlo, Sarah, Ron Kooijman, Ilse Beck, Krzysztof Kolmus, Anneleen Spooren, and Guy Haegeman. 2011. “Cyclic AMP: a Selective Modulator of NF-κB Action.” Cellular and Molecular Life Sciences 68 (23): 3823–3841.
APA
Gerlo, S., Kooijman, R., Beck, I., Kolmus, K., Spooren, A., & Haegeman, G. (2011). Cyclic AMP: a selective modulator of NF-κB action. CELLULAR AND MOLECULAR LIFE SCIENCES, 68(23), 3823–3841.
Vancouver
1.
Gerlo S, Kooijman R, Beck I, Kolmus K, Spooren A, Haegeman G. Cyclic AMP: a selective modulator of NF-κB action. CELLULAR AND MOLECULAR LIFE SCIENCES. 2011;68(23):3823–41.
MLA
Gerlo, Sarah, Ron Kooijman, Ilse Beck, et al. “Cyclic AMP: a Selective Modulator of NF-κB Action.” CELLULAR AND MOLECULAR LIFE SCIENCES 68.23 (2011): 3823–3841. Print.