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The influence of acute vagus nerve stimulation on regional brain perfusion in the normal dog, a micro-SPECT study

Valentine Martlé UGent, Kathelijne Peremans UGent, Robrecht Raedt UGent, Simon Vermeire UGent, Kristl Vonck UGent, Paul Boon UGent, Luc Van Ham UGent, Mulenda Tshamala UGent, Jacques Caemaert UGent and André Dobbeleir, et al. (2011) JOURNAL OF VETERINARY INTERNAL MEDICINE.
abstract
Vagus nerve stimulation (VNS) is an effective adjunctive treatment for refractory epilepsy, but its mechanism of action is still unknown. Functional neuroimaging studies can provide better insight into possible brain circuitry changes caused by VNS. This µ-SPECT study investigated the effects of two acute VNS paradigms on regional brain perfusion in normal dogs. A Cyberonics® pulse generator and helical electrodes were implanted in 10 Beagle dogs in the left cervical region. A cross-over study started 1 month after implantation. 99mTechnetium-ECD µ-SPECT was performed after 3 different paradigms (1 hour of sham, rapid-cycling and microburst VNS) with a wash out period of at least 1 week between different paradigms. VNS started 45 minutes before tracer injection and was continued for 10 more minutes after tracer injection. Acquisition was performed using a triple head gamma camera equipped with ultra high resolution multi pinhole collimators. Nineteen volumes of interest (VOIs) were evaluated by semi-quantitative analysis using BRASS software and for every VOI a regional perfusion index was calculated. Statistical analysis was performed using an F-test (mixed-effects model) to compare the regional perfusion indices for the 3 different conditions within each dog. One dog was excluded because of the development of Horner’s syndrome after implantation. Acute rapid-cycling VNS did not cause significant regional brain perfusion alterations. Acute microburst VNS caused a significant hypoperfusion in the left frontal lobe (p= 0.031) and in the right parietal lobe (p=0.047). In conclusion, acute microburst VNS modulates frontal and parietal cortical perfusion in the normal dog.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
in
JOURNAL OF VETERINARY INTERNAL MEDICINE
J. Vet. Intern. Med.
conference name
24th Annual symposium of the European Society of Veterinary Neurology
conference location
Trier, Germany
conference start
2011-09-22
conference end
2011-09-24
JCR category
VETERINARY SCIENCES
JCR impact factor
1.992 (2011)
JCR rank
15/141 (2011)
JCR quartile
1 (2011)
ISSN
0891-6640
language
English
UGent publication?
yes
classification
C3
id
1983335
handle
http://hdl.handle.net/1854/LU-1983335
date created
2012-01-11 12:55:57
date last changed
2012-01-16 14:46:56
@inproceedings{1983335,
  abstract     = {Vagus nerve stimulation (VNS) is an effective adjunctive treatment for refractory epilepsy, but its mechanism of action is still unknown. Functional neuroimaging studies can provide better insight into possible brain circuitry changes caused by VNS. This {\textmu}-SPECT study investigated the effects of two acute VNS paradigms on regional brain perfusion in normal dogs.
A Cyberonics{\textregistered} pulse generator and helical electrodes were implanted in 10 Beagle dogs in the left cervical region. A cross-over study started 1 month after implantation. 99mTechnetium-ECD {\textmu}-SPECT was performed after 3 different paradigms (1 hour of sham, rapid-cycling and microburst VNS) with a wash out period of at least 1 week between different paradigms. VNS started 45 minutes before tracer injection and was continued for 10 more minutes after tracer injection. Acquisition was performed using a triple head gamma camera equipped with ultra high resolution multi pinhole collimators. Nineteen volumes of interest (VOIs) were evaluated by semi-quantitative analysis using BRASS software and for every VOI a regional perfusion index was calculated. Statistical analysis was performed using an F-test (mixed-effects model) to compare the regional perfusion indices for the 3 different conditions within each dog.
One dog was excluded because of the development of Horner{\textquoteright}s syndrome after implantation. Acute rapid-cycling VNS did not cause significant regional brain perfusion alterations. Acute microburst VNS caused a significant hypoperfusion in the left frontal lobe (p= 0.031) and in the right parietal lobe (p=0.047).
In conclusion, acute microburst VNS modulates frontal and parietal cortical perfusion in the normal dog.},
  author       = {Martl{\'e}, Valentine and Peremans, Kathelijne and Raedt, Robrecht and Vermeire, Simon and Vonck, Kristl and Boon, Paul and Van Ham, Luc and Tshamala, Mulenda and Caemaert, Jacques and Dobbeleir, Andr{\'e} and Duchateau, Luc and Waelbers, Tim and Gielen, Ingrid and Bhatti, Sofie},
  booktitle    = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  issn         = {0891-6640},
  language     = {eng},
  location     = {Trier, Germany},
  title        = {The influence of acute vagus nerve stimulation on regional brain perfusion in the normal dog, a micro-SPECT study},
  year         = {2011},
}

Chicago
Martlé, Valentine, Kathelijne Peremans, Robrecht Raedt, Simon Vermeire, Kristl Vonck, Paul Boon, Luc Van Ham, et al. 2011. “The Influence of Acute Vagus Nerve Stimulation on Regional Brain Perfusion in the Normal Dog, a micro-SPECT Study.” In Journal of Veterinary Internal Medicine.
APA
Martlé, V., Peremans, K., Raedt, R., Vermeire, S., Vonck, K., Boon, P., Van Ham, L., et al. (2011). The influence of acute vagus nerve stimulation on regional brain perfusion in the normal dog, a micro-SPECT study. JOURNAL OF VETERINARY INTERNAL MEDICINE. Presented at the 24th Annual symposium of the European Society of Veterinary Neurology.
Vancouver
1.
Martlé V, Peremans K, Raedt R, Vermeire S, Vonck K, Boon P, et al. The influence of acute vagus nerve stimulation on regional brain perfusion in the normal dog, a micro-SPECT study. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2011.
MLA
Martlé, Valentine, Kathelijne Peremans, Robrecht Raedt, et al. “The Influence of Acute Vagus Nerve Stimulation on Regional Brain Perfusion in the Normal Dog, a micro-SPECT Study.” Journal of Veterinary Internal Medicine. 2011. Print.