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Galectin-11 induction in the gastrointestinal tract of cattle following nematode and protozoan infections

Prisca Hoorens UGent, Manuela Rinaldi UGent, Belgacem Mihi UGent, Leentje Dreesen UGent, Grietje Grit UGent, E Meeusen, RW Li and Peter Geldhof UGent (2011) PARASITE IMMUNOLOGY. 33(12). p.669-678
abstract
Galectin-11 (LGALS11) has been suggested to play an important role in protective immunity against gastrointestinal nematodes in ruminants. However, in cattle, this molecule has not been characterized in detail. In the current study, it was shown that transcription of LGALS11 was highly inducible in the bovine abomasal mucosa after an Ostertagia ostertagi infection. LGALS11 protein expression was also increased in the abomasal mucosa following O. ostertagi infection and localized to the nucleus and cytoplasm of epithelial cells and the mucus. Using in vitro abomasal epithelial cell cultures, it was shown that LGALS11 induction was associated with the proliferative and dedifferentiated status of cells. However, LGALS11 was not induced following stimulation with O. ostertagi excretory-secretory products. These results suggest that LGALS11 induction in vivo may be an indirect rather than a direct effect of the parasite on the epithelium. In addition, LGALS11 transcript was also detected in the abomasal lymph nodes where it was shown to be transcribed in MHCII(+) cells; however, transcription levels in the lymph nodes were not altered after O. ostertagi infection. In addition, LGALS11 was also induced in the small intestine by different types of parasites, including the nematode Cooperia oncophora and the protozoan parasite Giardia duodenalis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Giardia duodenalis, Ostertagia ostertagi, OSTERTAGIASIS, GENE, galectin-11, Dictyocaulus viviparous, Cooperia oncophora, bovine, RESISTANCE, INFLAMMATION, EXPULSION, BOVINE
journal title
PARASITE IMMUNOLOGY
Parasite Immunol.
volume
33
issue
12
pages
669 - 678
Web of Science type
Article
Web of Science id
000297744000004
JCR category
PARASITOLOGY
JCR impact factor
2.601 (2011)
JCR rank
11/33 (2011)
JCR quartile
2 (2011)
ISSN
0141-9838
DOI
10.1111/j.1365-3024.2011.01336.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1982593
handle
http://hdl.handle.net/1854/LU-1982593
date created
2012-01-11 09:44:40
date last changed
2012-01-16 13:08:16
@article{1982593,
  abstract     = {Galectin-11 (LGALS11) has been suggested to play an important role in protective immunity against gastrointestinal nematodes in ruminants. However, in cattle, this molecule has not been characterized in detail. In the current study, it was shown that transcription of LGALS11 was highly inducible in the bovine abomasal mucosa after an Ostertagia ostertagi infection. LGALS11 protein expression was also increased in the abomasal mucosa following O. ostertagi infection and localized to the nucleus and cytoplasm of epithelial cells and the mucus. Using in vitro abomasal epithelial cell cultures, it was shown that LGALS11 induction was associated with the proliferative and dedifferentiated status of cells. However, LGALS11 was not induced following stimulation with O. ostertagi excretory-secretory products. These results suggest that LGALS11 induction in vivo may be an indirect rather than a direct effect of the parasite on the epithelium. In addition, LGALS11 transcript was also detected in the abomasal lymph nodes where it was shown to be transcribed in MHCII(+) cells; however, transcription levels in the lymph nodes were not altered after O. ostertagi infection. In addition, LGALS11 was also induced in the small intestine by different types of parasites, including the nematode Cooperia oncophora and the protozoan parasite Giardia duodenalis.},
  author       = {Hoorens, Prisca and Rinaldi, Manuela and Mihi, Belgacem and Dreesen, Leentje and Grit, Grietje and Meeusen, E and Li, RW and Geldhof, Peter},
  issn         = {0141-9838},
  journal      = {PARASITE IMMUNOLOGY},
  keyword      = {Giardia duodenalis,Ostertagia ostertagi,OSTERTAGIASIS,GENE,galectin-11,Dictyocaulus viviparous,Cooperia oncophora,bovine,RESISTANCE,INFLAMMATION,EXPULSION,BOVINE},
  language     = {eng},
  number       = {12},
  pages        = {669--678},
  title        = {Galectin-11 induction in the gastrointestinal tract of cattle following nematode and protozoan infections},
  url          = {http://dx.doi.org/10.1111/j.1365-3024.2011.01336.x},
  volume       = {33},
  year         = {2011},
}

Chicago
Hoorens, Prisca, Manuela Rinaldi, Belgacem Mihi, Leentje Dreesen, Grietje Grit, E Meeusen, RW Li, and Peter Geldhof. 2011. “Galectin-11 Induction in the Gastrointestinal Tract of Cattle Following Nematode and Protozoan Infections.” Parasite Immunology 33 (12): 669–678.
APA
Hoorens, P., Rinaldi, M., Mihi, B., Dreesen, L., Grit, G., Meeusen, E., Li, R., et al. (2011). Galectin-11 induction in the gastrointestinal tract of cattle following nematode and protozoan infections. PARASITE IMMUNOLOGY, 33(12), 669–678.
Vancouver
1.
Hoorens P, Rinaldi M, Mihi B, Dreesen L, Grit G, Meeusen E, et al. Galectin-11 induction in the gastrointestinal tract of cattle following nematode and protozoan infections. PARASITE IMMUNOLOGY. 2011;33(12):669–78.
MLA
Hoorens, Prisca, Manuela Rinaldi, Belgacem Mihi, et al. “Galectin-11 Induction in the Gastrointestinal Tract of Cattle Following Nematode and Protozoan Infections.” PARASITE IMMUNOLOGY 33.12 (2011): 669–678. Print.