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Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc

Barbara Berckmans UGent, Tim Lammens UGent, Hilde Van Den Daele UGent, Zoltan Magyar, Laszlo Bögre and Lieven De Veylder UGent (2011) PLANT PHYSIOLOGY. 157(3). p.1440-1451
abstract
Endoreduplication represents a variation on the cell cycle in which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, thereby increasing the cellular DNA content. It is known that the DNA ploidy level of cells is controlled by external stimuli such as light; however, limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we had demonstrated that the conversion from a mitotic cell cycle into an endoreduplication cycle is controlled by the atypical E2F transcription factor, DP-E2F-LIKE1 (DEL1), that represses the endocycle onset. Here, the Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control its transcript levels through competition for a single E2F cis-acting binding site. In accordance with the reported opposite effects of light on the protein levels of E2Fb and E2Fc, DEL1 transcription depended on the light regime. Strikingly, modified DEL1 expression levels uncoupled the link between light and endoreduplication in hypocotyls, implying that DEL1 acts as a regulatory connection between endocycle control and the photomorphogenic response.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TRANSCRIPTION FACTOR, ARABIDOPSIS-THALIANA, MAIZE ENDOSPERM, CELL-CYCLE REGULATION, DNA ENDOREDUPLICATION, PLANT DEVELOPMENT, GENE-EXPRESSION, HYPOCOTYL GROWTH, WATER-DEFICIT, TOMATO FRUIT
journal title
PLANT PHYSIOLOGY
Plant Physiol.
volume
157
issue
3
pages
1440 - 1451
Web of Science type
Article
Web of Science id
000296722300036
JCR category
PLANT SCIENCES
JCR impact factor
6.535 (2011)
JCR rank
7/189 (2011)
JCR quartile
1 (2011)
ISSN
0032-0889
DOI
10.1104/pp.111.183384
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1982092
handle
http://hdl.handle.net/1854/LU-1982092
date created
2012-01-10 16:28:12
date last changed
2012-01-24 15:39:08
@article{1982092,
  abstract     = {Endoreduplication represents a variation on the cell cycle in which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, thereby increasing the cellular DNA content. It is known that the DNA ploidy level of cells is controlled by external stimuli such as light; however, limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we had demonstrated that the conversion from a mitotic cell cycle into an endoreduplication cycle is controlled by the atypical E2F transcription factor, DP-E2F-LIKE1 (DEL1), that represses the endocycle onset. Here, the Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control its transcript levels through competition for a single E2F cis-acting binding site. In accordance with the reported opposite effects of light on the protein levels of E2Fb and E2Fc, DEL1 transcription depended on the light regime. Strikingly, modified DEL1 expression levels uncoupled the link between light and endoreduplication in hypocotyls, implying that DEL1 acts as a regulatory connection between endocycle control and the photomorphogenic response.},
  author       = {Berckmans, Barbara and Lammens, Tim and Van Den Daele, Hilde and Magyar, Zoltan and B{\"o}gre, Laszlo and De Veylder, Lieven},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keyword      = {TRANSCRIPTION FACTOR,ARABIDOPSIS-THALIANA,MAIZE ENDOSPERM,CELL-CYCLE REGULATION,DNA ENDOREDUPLICATION,PLANT DEVELOPMENT,GENE-EXPRESSION,HYPOCOTYL GROWTH,WATER-DEFICIT,TOMATO FRUIT},
  language     = {eng},
  number       = {3},
  pages        = {1440--1451},
  title        = {Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc},
  url          = {http://dx.doi.org/10.1104/pp.111.183384},
  volume       = {157},
  year         = {2011},
}

Chicago
Berckmans, Barbara, Tim Lammens, Hilde Van Den Daele, Zoltan Magyar, Laszlo Bögre, and Lieven De Veylder. 2011. “Light-dependent Regulation of DEL1 Is Determined by the Antagonistic Action of E2Fb and E2Fc.” Plant Physiology 157 (3): 1440–1451.
APA
Berckmans, B., Lammens, T., Van Den Daele, H., Magyar, Z., Bögre, L., & De Veylder, L. (2011). Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc. PLANT PHYSIOLOGY, 157(3), 1440–1451.
Vancouver
1.
Berckmans B, Lammens T, Van Den Daele H, Magyar Z, Bögre L, De Veylder L. Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc. PLANT PHYSIOLOGY. 2011;157(3):1440–51.
MLA
Berckmans, Barbara, Tim Lammens, Hilde Van Den Daele, et al. “Light-dependent Regulation of DEL1 Is Determined by the Antagonistic Action of E2Fb and E2Fc.” PLANT PHYSIOLOGY 157.3 (2011): 1440–1451. Print.