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M-cells are damaged and increased in number in inflamed human ileal mucosa

Claude Cuvelier, Jozef Quatacker, Herman Mielants, Martine De Vos UGent, Eric Veys and Hendrik Roels (1994) HISTOPATHOLOGY. 24(5). p.417-426
abstract
Ileocolonoscopy and biopsies of patients with spondylarthropathy reveal gut inflammation in 62% of cases. In order to better understand the pathogenetic mechanisms of spondylarthropathy-related gut inflammation, the follicle-associated epithelium was examined. Biopsies from nine controls and 18 patients with spondylarthropathy were studied by electronmicroscopy. Membranous (M) cells were investigated in normal and inflamed ileum. In normal mucosa, M-cells were scarce whereas in inflamed mucosa their number was increased (up to 24% of follicle-associated epithelial cells). They showed a thin rim of cytoplasm covering groups of lymphocytes. In chronic ileitis, necrotic M-cells, rupture of M-cells and lymphocytes entering the gut lumen were observed. The bursting of M-ceIls at the top of the lymphoid follicles leads to interruption of the gut epithelial lining and gives the luminal content access to the lymphoid tissue. This pathogenetic mechanism may cause aphthoid ulcers.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ILEITIS, M-CELLS, SPONDYLARTHROPATHY, CROHNS DISEASE, ELECTRON-MICROSCOPY, INFLAMMATORY BOWEL-DISEASE, HUMAN PEYERS PATCHES, CROHNS-DISEASE, SERONEGATIVE SPONDYLARTHROPATHY, REACTIVE ARTHRITIS, EPITHELIAL-CELLS, MONONUCLEAR-CELLS, GUT INFLAMMATION, EXPRESSION, ILEOCOLONOSCOPY
journal title
HISTOPATHOLOGY
Histopathology
volume
24
issue
5
pages
417 - 426
Web of Science type
Article
ISSN
0309-0167
DOI
10.1111/j.1365-2559.1994.tb00550.x
language
English
UGent publication?
yes
classification
A1
id
198088
handle
http://hdl.handle.net/1854/LU-198088
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:39:01
@article{198088,
  abstract     = {Ileocolonoscopy and biopsies of patients with spondylarthropathy reveal gut inflammation in 62\% of cases. In order to better understand the pathogenetic mechanisms of spondylarthropathy-related gut inflammation, the follicle-associated epithelium was examined. Biopsies from nine controls and 18 patients with spondylarthropathy were studied by electronmicroscopy. Membranous (M) cells were investigated in normal and inflamed ileum. In normal mucosa, M-cells were scarce whereas in inflamed mucosa their number was increased (up to 24\% of follicle-associated epithelial cells). They showed a thin rim of cytoplasm covering groups of lymphocytes. In chronic ileitis, necrotic M-cells, rupture of M-cells and lymphocytes entering the gut lumen were observed. The bursting of M-ceIls at the top of the lymphoid follicles leads to interruption of the gut epithelial lining and gives the luminal content access to the lymphoid tissue. This pathogenetic mechanism may cause aphthoid ulcers.},
  author       = {Cuvelier, Claude and Quatacker, Jozef and Mielants, Herman and De Vos, Martine and Veys, Eric and Roels, Hendrik},
  issn         = {0309-0167},
  journal      = {HISTOPATHOLOGY},
  keyword      = {ILEITIS,M-CELLS,SPONDYLARTHROPATHY,CROHNS DISEASE,ELECTRON-MICROSCOPY,INFLAMMATORY BOWEL-DISEASE,HUMAN PEYERS PATCHES,CROHNS-DISEASE,SERONEGATIVE SPONDYLARTHROPATHY,REACTIVE ARTHRITIS,EPITHELIAL-CELLS,MONONUCLEAR-CELLS,GUT INFLAMMATION,EXPRESSION,ILEOCOLONOSCOPY},
  language     = {eng},
  number       = {5},
  pages        = {417--426},
  title        = {M-cells are damaged and increased in number in inflamed human ileal mucosa},
  url          = {http://dx.doi.org/10.1111/j.1365-2559.1994.tb00550.x},
  volume       = {24},
  year         = {1994},
}

Chicago
Cuvelier, Claude, Jozef Quatacker, Herman Mielants, Martine De Vos, Eric Veys, and Hendrik Roels. 1994. “M-cells Are Damaged and Increased in Number in Inflamed Human Ileal Mucosa.” Histopathology 24 (5): 417–426.
APA
Cuvelier, C., Quatacker, J., Mielants, H., De Vos, M., Veys, E., & Roels, H. (1994). M-cells are damaged and increased in number in inflamed human ileal mucosa. HISTOPATHOLOGY, 24(5), 417–426.
Vancouver
1.
Cuvelier C, Quatacker J, Mielants H, De Vos M, Veys E, Roels H. M-cells are damaged and increased in number in inflamed human ileal mucosa. HISTOPATHOLOGY. 1994;24(5):417–26.
MLA
Cuvelier, Claude, Jozef Quatacker, Herman Mielants, et al. “M-cells Are Damaged and Increased in Number in Inflamed Human Ileal Mucosa.” HISTOPATHOLOGY 24.5 (1994): 417–426. Print.