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Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface

Karishma Palande, Onno Roovers, Judith Gits, Carola Verwijmeren, Yoshihito Iuchi, Junichi Fujii, Benjamin G Neel, Robert Karisch, Jan Tavernier UGent and Ivo P Touw (2011) JOURNAL OF CELL SCIENCE. 124(21). p.3695-3705
abstract
Reactive oxygen species (ROS) regulate growth factor receptor signalling at least in part by inhibiting oxidation-sensitive phosphatases. An emerging concept is that ROS act locally to affect signal transduction in different subcellular compartments and that ROS levels are regulated by antioxidant proteins at the same local level. Here, we show that the ER-resident antioxidant peroxiredoxin 4 (Prdx4) interacts with the cytoplasmic domain of the granulocyte colony-stimulating factor receptor (G-CSFR). This interaction occurs when the activated G-CSFR resides in early endosomes. Prdx4 inhibits G-CSF-induced signalling and proliferation in myeloid progenitors, depending on its redox-active cysteine core. Protein tyrosine phosphatase 1b (Ptp1b) appears to be a major downstream effector controlling these responses. Conversely, Ptp1b might keep Prdx4 active by reducing its phosphorylation. These findings unveil a new signal transduction regulatory circuitry involving redox-controlled processes in the ER and activated cytokine receptors in endosomes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DISTINCT, TRANSDUCTION, ACTIVATION, GRANULOCYTE, FACTOR-RECEPTOR, TYROSINE-PHOSPHATASE 1B, REACTIVE OXYGEN, ACUTE MYELOID-LEUKEMIA, SEVERE CONGENITAL NEUTROPENIA, COLONY-STIMULATING-FACTOR, Redox signaling, Granulocyte colony-stimulating factor, Hematopoiesis, Protein tyrosine phosphatase 1b, Peroxiredoxin
journal title
JOURNAL OF CELL SCIENCE
J. Cell Sci.
volume
124
issue
21
pages
3695 - 3705
Web of Science type
Article
Web of Science id
000296975300017
JCR category
CELL BIOLOGY
JCR impact factor
6.111 (2011)
JCR rank
38/178 (2011)
JCR quartile
1 (2011)
ISSN
0021-9533
DOI
10.1242/jcs.089656
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1980370
handle
http://hdl.handle.net/1854/LU-1980370
date created
2012-01-09 10:06:07
date last changed
2018-06-21 08:22:37
@article{1980370,
  abstract     = {Reactive oxygen species (ROS) regulate growth factor receptor signalling at least in part by inhibiting oxidation-sensitive phosphatases. An emerging concept is that ROS act locally to affect signal transduction in different subcellular compartments and that ROS levels are regulated by antioxidant proteins at the same local level. Here, we show that the ER-resident antioxidant peroxiredoxin 4 (Prdx4) interacts with the cytoplasmic domain of the granulocyte colony-stimulating factor receptor (G-CSFR). This interaction occurs when the activated G-CSFR resides in early endosomes. Prdx4 inhibits G-CSF-induced signalling and proliferation in myeloid progenitors, depending on its redox-active cysteine core. Protein tyrosine phosphatase 1b (Ptp1b) appears to be a major downstream effector controlling these responses. Conversely, Ptp1b might keep Prdx4 active by reducing its phosphorylation. These findings unveil a new signal transduction regulatory circuitry involving redox-controlled processes in the ER and activated cytokine receptors in endosomes.},
  author       = {Palande, Karishma and Roovers, Onno and Gits, Judith and Verwijmeren, Carola and Iuchi, Yoshihito and Fujii, Junichi and Neel, Benjamin G and Karisch, Robert and Tavernier, Jan and Touw, Ivo P},
  issn         = {0021-9533},
  journal      = {JOURNAL OF CELL SCIENCE},
  keyword      = {DISTINCT,TRANSDUCTION,ACTIVATION,GRANULOCYTE,FACTOR-RECEPTOR,TYROSINE-PHOSPHATASE 1B,REACTIVE OXYGEN,ACUTE MYELOID-LEUKEMIA,SEVERE CONGENITAL NEUTROPENIA,COLONY-STIMULATING-FACTOR,Redox signaling,Granulocyte colony-stimulating factor,Hematopoiesis,Protein tyrosine phosphatase 1b,Peroxiredoxin},
  language     = {eng},
  number       = {21},
  pages        = {3695--3705},
  title        = {Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface},
  url          = {http://dx.doi.org/10.1242/jcs.089656},
  volume       = {124},
  year         = {2011},
}

Chicago
Palande, Karishma, Onno Roovers, Judith Gits, Carola Verwijmeren, Yoshihito Iuchi, Junichi Fujii, Benjamin G Neel, Robert Karisch, Jan Tavernier, and Ivo P Touw. 2011. “Peroxiredoxin-controlled G-CSF Signalling at the Endoplasmic Reticulum-early Endosome Interface.” Journal of Cell Science 124 (21): 3695–3705.
APA
Palande, K., Roovers, O., Gits, J., Verwijmeren, C., Iuchi, Y., Fujii, J., Neel, B. G., et al. (2011). Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface. JOURNAL OF CELL SCIENCE, 124(21), 3695–3705.
Vancouver
1.
Palande K, Roovers O, Gits J, Verwijmeren C, Iuchi Y, Fujii J, et al. Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface. JOURNAL OF CELL SCIENCE. 2011;124(21):3695–705.
MLA
Palande, Karishma, Onno Roovers, Judith Gits, et al. “Peroxiredoxin-controlled G-CSF Signalling at the Endoplasmic Reticulum-early Endosome Interface.” JOURNAL OF CELL SCIENCE 124.21 (2011): 3695–3705. Print.