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HAb18G/CD147 Promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells

Pu Zhao, Wei Zhang, Shi-Jie Wang, Xiao-Ling Yu, Juan Tang, Wan Huang, Yong Li, Hong-Yong Cui, Yun-Shan Guo and Jan Tavernier UGent, et al. (2011) HEPATOLOGY. 54(6). p.2012-2024
abstract
Tumor cells can move as individual cells in two interconvertible modes: mesenchymal mode and amoeboid mode. Cytoskeleton rearrangement plays an important role in the interconversion. Previously, we reported that HAb18G/CD147 and annexin II are interacting proteins involved in cytoskeleton rearrangement, yet the role of their interaction is unclear. In this study we found that the depletion of HAb18G/CD147 produced a rounded morphology, which is associated with amoeboid movement, whereas the depletion of annexin II resulted in an elongated morphology, which is associated with mesenchymal movement. The extracellular portion of HAb18G/CD147 can interact with a phosphorylation-inactive mutant of annexin II and inhibit its phosphorylation. HAb18G/CD147 inhibits Rho signaling pathways and amoeboid movement by inhibiting annexin II phosphorylation, promotes membrane localization of WAVE2 and Rac1 activation by way of the integrin-FAK-PI3K/PIP3 signaling pathway, and promotes the formation of lamellipodia and mesenchymal movement. Conclusion: These results suggest that the interaction of HAb18G/CD147 with annexin II is involved in the interconversion between mesenchymal and amoeboid movement of hepatocellular carcinoma cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HUMAN HEPATOMA-CELLS, PERICELLULAR PROTEOLYSIS, MCT4 EXPRESSION, INVASION, ADHESION, MEMBRANE, DYNAMICS, METASTASIS, MIGRATION, IN-VITRO
journal title
HEPATOLOGY
Hepatology
volume
54
issue
6
pages
2012 - 2024
Web of Science type
Article
Web of Science id
000297974900014
JCR category
GASTROENTEROLOGY & HEPATOLOGY
JCR impact factor
11.665 (2011)
JCR rank
2/73 (2011)
JCR quartile
1 (2011)
ISSN
0270-9139
DOI
10.1002/hep.24592
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1980174
handle
http://hdl.handle.net/1854/LU-1980174
date created
2012-01-06 15:52:16
date last changed
2013-01-30 09:41:21
@article{1980174,
  abstract     = {Tumor cells can move as individual cells in two interconvertible modes: mesenchymal mode and amoeboid mode. Cytoskeleton rearrangement plays an important role in the interconversion. Previously, we reported that HAb18G/CD147 and annexin II are interacting proteins involved in cytoskeleton rearrangement, yet the role of their interaction is unclear. In this study we found that the depletion of HAb18G/CD147 produced a rounded morphology, which is associated with amoeboid movement, whereas the depletion of annexin II resulted in an elongated morphology, which is associated with mesenchymal movement. The extracellular portion of HAb18G/CD147 can interact with a phosphorylation-inactive mutant of annexin II and inhibit its phosphorylation. HAb18G/CD147 inhibits Rho signaling pathways and amoeboid movement by inhibiting annexin II phosphorylation, promotes membrane localization of WAVE2 and Rac1 activation by way of the integrin-FAK-PI3K/PIP3 signaling pathway, and promotes the formation of lamellipodia and mesenchymal movement. Conclusion: These results suggest that the interaction of HAb18G/CD147 with annexin II is involved in the interconversion between mesenchymal and amoeboid movement of hepatocellular carcinoma cells.},
  author       = {Zhao, Pu and Zhang, Wei and Wang, Shi-Jie and Yu, Xiao-Ling and Tang, Juan and Huang, Wan and Li, Yong and Cui, Hong-Yong and Guo, Yun-Shan and Tavernier, Jan and Zhang, Si-He and Jiang, Jian-Li and Chen, Zhi-Nan},
  issn         = {0270-9139},
  journal      = {HEPATOLOGY},
  keyword      = {HUMAN HEPATOMA-CELLS,PERICELLULAR PROTEOLYSIS,MCT4 EXPRESSION,INVASION,ADHESION,MEMBRANE,DYNAMICS,METASTASIS,MIGRATION,IN-VITRO},
  language     = {eng},
  number       = {6},
  pages        = {2012--2024},
  title        = {HAb18G/CD147 Promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells},
  url          = {http://dx.doi.org/10.1002/hep.24592},
  volume       = {54},
  year         = {2011},
}

Chicago
Zhao, Pu, Wei Zhang, Shi-Jie Wang, Xiao-Ling Yu, Juan Tang, Wan Huang, Yong Li, et al. 2011. “HAb18G/CD147 Promotes Cell Motility by Regulating Annexin II-activated RhoA and Rac1 Signaling Pathways in Hepatocellular Carcinoma Cells.” Hepatology 54 (6): 2012–2024.
APA
Zhao, P., Zhang, W., Wang, S.-J., Yu, X.-L., Tang, J., Huang, W., Li, Y., et al. (2011). HAb18G/CD147 Promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. HEPATOLOGY, 54(6), 2012–2024.
Vancouver
1.
Zhao P, Zhang W, Wang S-J, Yu X-L, Tang J, Huang W, et al. HAb18G/CD147 Promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. HEPATOLOGY. 2011;54(6):2012–24.
MLA
Zhao, Pu, Wei Zhang, Shi-Jie Wang, et al. “HAb18G/CD147 Promotes Cell Motility by Regulating Annexin II-activated RhoA and Rac1 Signaling Pathways in Hepatocellular Carcinoma Cells.” HEPATOLOGY 54.6 (2011): 2012–2024. Print.