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Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men

Johannes Ruige, Ernst Rietzschel UGent, Marc De Buyzere, Sofie Bekaert UGent, Patrick Segers UGent, Dirk De Bacquer UGent, Gui De Backer UGent, Thierry Gillebert UGent, Jean Kaufman UGent and the Asklepios Investigators (2011) INTERNATIONAL JOURNAL OF ANDROLOGY. 34(6). p.e587-e593
abstract
In healthy middle-aged men, endogenous testosterone does not seem to increase risk for cardiovascular disease (CVD). One explanation might be a differential effect of testosterone, and another, interference with oestradiol with respect to specific cardiovascular functions. To investigate these possibilities, we evaluated in a cross-sectional population of 1223 healthy men, aged 46 (6) years, associations between endogenous testosterone, oestradiol and left ventricular structure and function (echocardiography). Testosterone was inversely associated with ejection fraction (EF) and with more sensitive systolic tissue Doppler imaging indices. Oestradiol was positively associated with EF. These associations were confirmed by linear regression analyses, and consistent for calculated free as well as for total sex steroid concentrations. Standardized regression coefficients were -0.13 for testosterone (P < 0.01) and 0.12 for oestradiol (P < 0.01) for the association with EF, in a model which included height, waist circumference, triglycerides, glucose, systolic blood pressure, drug-treated hypertension, heart rate, haematocrit, current smoking, serum sampling time, age and excessive alcohol use. The study suggests an opposite link, albeit modestly, of testosterone and oestradiol with left ventricle systolic function in healthy middle-aged men. The finding provides a partial explanation for the overall neutral effect on CVD of testosterone in healthy middle-aged men.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MYOCARDIAL-INFARCTION, ESTROGEN THERAPY, SEX-HORMONES, 17-BETA-ESTRADIOL, testosterone, PRESSURE-OVERLOAD, CARDIAC-FUNCTION, oestradiol, HEART-FAILURE PATIENTS, POSTMYOCARDIAL INFARCTION, EJECTION FRACTION, left ventricular function, OXIDE SYNTHASE EXPRESSION, cardiovascular disease
journal title
INTERNATIONAL JOURNAL OF ANDROLOGY
Int. J. Androl.
volume
34
issue
6
pages
e587 - e593
Web of Science type
Article
Web of Science id
000297249900009
JCR category
ANDROLOGY
JCR impact factor
3.591 (2011)
JCR rank
1/6 (2011)
JCR quartile
1 (2011)
ISSN
0105-6263
DOI
10.1111/j.1365-2605.2011.01191.x
project
The Asklepios study
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1977877
handle
http://hdl.handle.net/1854/LU-1977877
date created
2012-01-04 10:09:16
date last changed
2016-12-19 15:42:22
@article{1977877,
  abstract     = {In healthy middle-aged men, endogenous testosterone does not seem to increase risk for cardiovascular disease (CVD). One explanation might be a differential effect of testosterone, and another, interference with oestradiol with respect to specific cardiovascular functions. To investigate these possibilities, we evaluated in a cross-sectional population of 1223 healthy men, aged 46 (6) years, associations between endogenous testosterone, oestradiol and left ventricular structure and function (echocardiography). Testosterone was inversely associated with ejection fraction (EF) and with more sensitive systolic tissue Doppler imaging indices. Oestradiol was positively associated with EF. These associations were confirmed by linear regression analyses, and consistent for calculated free as well as for total sex steroid concentrations. Standardized regression coefficients were -0.13 for testosterone (P {\textlangle} 0.01) and 0.12 for oestradiol (P {\textlangle} 0.01) for the association with EF, in a model which included height, waist circumference, triglycerides, glucose, systolic blood pressure, drug-treated hypertension, heart rate, haematocrit, current smoking, serum sampling time, age and excessive alcohol use. The study suggests an opposite link, albeit modestly, of testosterone and oestradiol with left ventricle systolic function in healthy middle-aged men. The finding provides a partial explanation for the overall neutral effect on CVD of testosterone in healthy middle-aged men.},
  author       = {Ruige, Johannes and Rietzschel, Ernst and De Buyzere, Marc and Bekaert, Sofie and Segers, Patrick and De Bacquer, Dirk and De Backer, Gui and Gillebert, Thierry and Kaufman, Jean and Asklepios Investigators, the},
  issn         = {0105-6263},
  journal      = {INTERNATIONAL JOURNAL OF ANDROLOGY},
  keyword      = {MYOCARDIAL-INFARCTION,ESTROGEN THERAPY,SEX-HORMONES,17-BETA-ESTRADIOL,testosterone,PRESSURE-OVERLOAD,CARDIAC-FUNCTION,oestradiol,HEART-FAILURE PATIENTS,POSTMYOCARDIAL INFARCTION,EJECTION FRACTION,left ventricular function,OXIDE SYNTHASE EXPRESSION,cardiovascular disease},
  language     = {eng},
  number       = {6},
  pages        = {e587--e593},
  title        = {Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men},
  url          = {http://dx.doi.org/10.1111/j.1365-2605.2011.01191.x},
  volume       = {34},
  year         = {2011},
}

Chicago
Ruige, Johannes, Ernst Rietzschel, MARC DE BUYZERE, Sofie Bekaert, Patrick Segers, Dirk De Bacquer, Gui De Backer, Thierry Gillebert, Jean Kaufman, and the Asklepios Investigators. 2011. “Modest Opposite Associations of Endogenous Testosterone and Oestradiol with Left Ventricular Remodelling and Function in Healthy Middle-aged Men.” International Journal of Andrology 34 (6): e587–e593.
APA
Ruige, J., Rietzschel, E., DE BUYZERE, M., Bekaert, S., Segers, P., De Bacquer, D., De Backer, G., et al. (2011). Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men. INTERNATIONAL JOURNAL OF ANDROLOGY, 34(6), e587–e593.
Vancouver
1.
Ruige J, Rietzschel E, DE BUYZERE M, Bekaert S, Segers P, De Bacquer D, et al. Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men. INTERNATIONAL JOURNAL OF ANDROLOGY. 2011;34(6):e587–e593.
MLA
Ruige, Johannes, Ernst Rietzschel, MARC DE BUYZERE, et al. “Modest Opposite Associations of Endogenous Testosterone and Oestradiol with Left Ventricular Remodelling and Function in Healthy Middle-aged Men.” INTERNATIONAL JOURNAL OF ANDROLOGY 34.6 (2011): e587–e593. Print.