Ghent University Academic Bibliography

Advanced

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

Maria Regina Orofino Kreuger, Bruna Gonçalves Farias, Janaína Moreira, Luise Zozula Blind, Solomon Kweku Sagoe Amoah, Andreia Siqueira Leite, Maique Weber Biavatti, Tom Van Hoof UGent, Katharina D'Herde UGent and Alexandre Bella Cruz (2012) REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY. 22(1). p.123-130
abstract
We investigated the healing process on excisional wounds infected with Staphylococcus aureus in rats, treated with 50 mu L of ethyl acetate III from Vernonia scorpioides (Lam.) Pers., Asteraceae, rifamycin diethylamide B 25 mg, or saline. The lesions were measured daily and after seven days were surgically removed and histologically processed. The results indicate a favorable action of the EAIII, demonstrated by the increased wound contraction, smaller area of necrotic tissue, good development of granulation tissue, extensive extracellular matrix deposition and epithelial regeneration. This sub-fraction was phytochemically investigated in parallel studies, revealing the presence of sesquiterpene lactones (glaucolides and hirsutinolides) such as diacethylpiptocarphol and related hirsutinolides, flavonoids and cinnamic acid derivatives and also a new polyacetylene, which have been previously published. Results support the effectiveness of V. scorpioides antimicrobial activity in infected wound healing in rats.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Vernonia scorpioides, ethyl acetate fraction, wound healing, Staphylococcus aureus, DIABETIC FOOT INFECTIONS, LAM. PERS. ASTERACEAE, SESQUITERPENE LACTONES, CYTOTOXIC ACTIVITY, TUMOR-CELLS, EXTRACTS, ANTIBACTERIAL, AMYGDALINA, GROWTH, MICE
journal title
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
volume
22
issue
1
pages
123 - 130
Web of Science type
Article
Web of Science id
000297789400018
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
0.676 (2012)
JCR rank
223/259 (2012)
JCR quartile
4 (2012)
ISSN
0102-695X
DOI
10.1590/S0102-695X2011005000192
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1977562
handle
http://hdl.handle.net/1854/LU-1977562
date created
2012-01-03 18:54:38
date last changed
2012-01-06 10:14:24
@article{1977562,
  abstract     = {We investigated the healing process on excisional wounds infected with Staphylococcus aureus in rats, treated with 50 mu L of ethyl acetate III from Vernonia scorpioides (Lam.) Pers., Asteraceae, rifamycin diethylamide B 25 mg, or saline. The lesions were measured daily and after seven days were surgically removed and histologically processed. The results indicate a favorable action of the EAIII, demonstrated by the increased wound contraction, smaller area of necrotic tissue, good development of granulation tissue, extensive extracellular matrix deposition and epithelial regeneration. This sub-fraction was phytochemically investigated in parallel studies, revealing the presence of sesquiterpene lactones (glaucolides and hirsutinolides) such as diacethylpiptocarphol and related hirsutinolides, flavonoids and cinnamic acid derivatives and also a new polyacetylene, which have been previously published. Results support the effectiveness of V. scorpioides antimicrobial activity in infected wound healing in rats.},
  author       = {Orofino Kreuger, Maria Regina and Farias, Bruna Gon\c{c}alves and Moreira, Jana{\'i}na and Blind, Luise Zozula and Sagoe Amoah, Solomon Kweku and Leite, Andreia Siqueira and Biavatti, Maique Weber and Van Hoof, Tom and D'Herde, Katharina and Cruz, Alexandre Bella},
  issn         = {0102-695X},
  journal      = {REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY},
  keyword      = {Vernonia scorpioides,ethyl acetate fraction,wound healing,Staphylococcus aureus,DIABETIC FOOT INFECTIONS,LAM. PERS. ASTERACEAE,SESQUITERPENE LACTONES,CYTOTOXIC ACTIVITY,TUMOR-CELLS,EXTRACTS,ANTIBACTERIAL,AMYGDALINA,GROWTH,MICE},
  language     = {eng},
  number       = {1},
  pages        = {123--130},
  title        = {Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats},
  url          = {http://dx.doi.org/10.1590/S0102-695X2011005000192},
  volume       = {22},
  year         = {2012},
}

Chicago
Orofino Kreuger, Maria Regina, Bruna Gonçalves Farias, Janaína Moreira, Luise Zozula Blind, Solomon Kweku Sagoe Amoah, Andreia Siqueira Leite, Maique Weber Biavatti, Tom Van Hoof, Katharina D’Herde, and Alexandre Bella Cruz. 2012. “Effects of the Topical Application of an Ethyl Acetate Fraction from Vernonia Scorpioides on Excisional Wounds Infected with Staphylococcus Aureus in Rats.” Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy 22 (1): 123–130.
APA
Orofino Kreuger, M. R., Farias, B. G., Moreira, J., Blind, L. Z., Sagoe Amoah, S. K., Leite, A. S., Biavatti, M. W., et al. (2012). Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 22(1), 123–130.
Vancouver
1.
Orofino Kreuger MR, Farias BG, Moreira J, Blind LZ, Sagoe Amoah SK, Leite AS, et al. Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY. 2012;22(1):123–30.
MLA
Orofino Kreuger, Maria Regina, Bruna Gonçalves Farias, Janaína Moreira, et al. “Effects of the Topical Application of an Ethyl Acetate Fraction from Vernonia Scorpioides on Excisional Wounds Infected with Staphylococcus Aureus in Rats.” REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY 22.1 (2012): 123–130. Print.